Objective To explore CT character for acidophilic granuloma of skull.Methods 15 cases diagnosed clinic,pathology and CT were retrospectively analyzed and 4 of 15 cases had skull X-ray examination.Results Lipid,small bone piece,parenchyma lump and endocranium erosio for acidophilic granuloma of skull were showed clearly and accurately in CT.Conclusion Lipid is important CT character for acidophilic granuloma of skull,a reliable diagnosis can be made when combine CT with clinical information.

Objective To investigate diagnostic value of low-tension computed tomography(CT) and magnetic resonance imaging(MRI) on carcinoma around Vater’s ampulla.Methods The data of CT and MRI of 30 patients with carcinoma around Vater’s ampulla confirmed by pathology were analysed retrospectively.Results 30 patients all had different degree obstruction of low part of biliary tract. CT or MRI showed the location, size and relationship with abjacent tissue of carcinoma in 26 patients, and the finger-stall sign of the descending part of the duodenum in 18 patients among them. Space occupying lesion of carcinoma was found dimly in 4 patients, no space occupying lesion of carcinoma was found in 3 patients.Conclusion The finger-stall sign of the descending part of the duodenum and finding of mass of ampulla are characteristic findings of carcinoma around Vaterys ampulla, low-tension CT and MRI are valuable methods of diagnosis of carcinoma around Vatery’s ampulla.

Objective The goal of this study is to know the level of radon in greenbelt soil in Chengdu city. Methods 152 monitoring sites were selected in the riverside, roadside, park, campus and residential area in Chengdu city. Concentration of radon in the soil was determined with KJD-2000R radon detector. Results Although the level of radon in the central area was higher than those in the peripheral area the level of radon in the riverside was higher than that in the parks, the mean level of radon investigated in this study (14 047 Bq/m3) was lower than the national mean level(7 300 Bq/m3). Conclusion It can be considered that the level of radon in the greenbelt soil in Chengdu city is in the normal range.

Objective To observe the effect of Shuxuening Injection NO, NOS, SOD and MDA on of angina pectoris patients. Methods 100 patients with angina pectoris were randomly divided into two groups. 50 patients in treatment group were treated with Shuxuening Injection, 5 mL once, drop into 250 mL 5% glucose injection (it change into 250 mL 0.9% sodium chloride injection if the patient have diabetes), one time a day. 50 patients in control group were treated with isosorbide mononitrate injection, 60 mg once, drop into 250 mL 5% glucose injection (it change into 250 mL 0.9% sodium chloride injection if the patient have diabetes), 15 gtt one minute, one time a day. Results NO, NOS and SOD of the treatment group were objective improved, and MDA objective reduced. NO improved from (47.61?8.76)?mol/L to (71.84? 13.26)?mol/L, NOS improved from (1.64?0.23)U/mL to (2.31?0.29)U/mL, SOD improved from (46.34? 5.62)U/mL to (64.54?9.10)U/mL, and MDA reduced from (8.96?1.76)U/mL to (6.71?1.43)U/mL. Total effective rate in improving angina pectoris was 96%, and ECG was 76%. The time (ischemic ST-T changes) of holter ECG was reduced from (130.45?18.61)min to (32.33?5.32)min, there was a significant difference between the two groups (P

Objective To study the effects of N,P,and K fertilizers on the growth and accumulation of secondary metabolites,to reveal the accumulation relationship between the biomass and the secondary metabolites in medicinal plants in the plantation,and to establish the basic theory of fertilization in medicinal plant culture.Methods Orthogonal design was used to study the effects of nine combinations of N,P, and K on the biomass and active constituents in three levels of three factors.While plants flowered,they were harvested,weighed,and smashed.Then contents of N,total caffee esters,and scutellarin were anaylzed.Results High amount of N,P,and K fertilizers was optimum to the accumulation of biomass, but low amount of N,P,and K fertilizers was optimum to the accumulation of total caffee esters and scutellarin.The N fertilizer significantly increased the biomass and decreased the content of total caffee esters and scutellarin in Erigeron breviscapus,but did not affect the active constituents yield.The effect of P on the accumulation of active constituents was higher than that of K,but its effect on the biomass accumulation was lower than that of K.The effect of K on the active constituents yield was the highest.Conclusion N,P,and K fertilizers could increase biomass and active constituents yield,nevertheless,decrease the contents of flavonoids in medicinal plants.

AIM: To compare the therapeutic effects of lacrimal duct retrograde catheterization, double loop antegrade catheterization, and lacrimal duct U-shaped catheter for patients with lacrimal duct obstruction.

METHODS: Totally 108 patients with lacrimal duct obstruction who were treated in our hospital from July 2015 to June 2018 were selected as subjects and prospectively studied. They were randomly divided into three groups: A(36 cases), B(36 cases), and C(36 cases). In group A, lacrimal duct retrograde catheterization was performed. Group B was treated with double-loop antegrade catheterization. Group C was treated with lacrimal duct U-shaped catheterization. All patients were followed up for 6mo. The intraoperative basic conditions(Lntraoperative blood loss, operation time, hospital stay), treatment efficacy, and the occurrence of complications and recurrence of lacrimal duct obstruction of the three groups were compared.

RESULTS: There were significant differences in the amount of intraoperative blood loss, operation time and hospital stay between the three groups(P<0.05). The total effective rate of treatment in group A was 91.7%, which was lower than 94.4% in group B and 97.2% in group C, but the difference in total effective rate between the three groups was statistically significant(P>0.05). The complication rate was 11.1% in group A, 5.6% higher than that in group B, and higher than 2.8% in group C(P=0.010). The recurrence rate of lacrimal duct obstruction in group A was 9.1%, higher than 5.9% in group B, higher than that in group C(P=0.029).

CONCLUSION: Retrograde catheterization of the lacrimal duct, double-loop antegrade catheterization, and lacrimal duct U-shaped tube for the treatment of patients with lacrimal duct obstruction have higher therapeutic effects, postoperative complications and less recurrence of lacrimal duct obstruction, but lacrimal passage Retrograde catheterization can reduce the amount of intraoperative blood loss, operation time, and U-shaped catheterization of the lacrimal duct can reduce the length of hospital stay, and can be widely used in clinical practice.

ObjectiveTo assess the relationship of filaggrin expression with atopic diathesis and disease severity in patients with alopecia areata (AA).MethodsThirty-seven patients with AA aged (26.3 ± 10.6) years were enrolled in this study.Atopic diseases were noted in 8 of these patients.Clinical data and laboratory test resuhs were reviewed.Immunohistochemical staining was performed to quantify the expression of filaggrin protein in scalp biopsy specimens from all of the 37 patients with AA and from 10 human controls,and fluorescence-based semiquantitative reverse transcription-PCR to detect the expression of filaggrin mRNA in scalp biopsy specimens from 22 patients with AA and 13 healthy controls.Data were statistically analyzed by Mann Whitney U test,chi-square test,and Spearman's rank correlation test.ResultsThe expressions of filaggrin protein and mRNA were significantly lower in patients with AA than in the controls(P ＜ 0.05 or 0.01 ),and the decrease seemed more obvious in patients with large areas of lesions,long duration of disease,and nail abnormalities,but the degree of decrease was unrelated to the complication with atopic diseases.No significant differences were observed in sex ratio,age at onset,disease duration,area of hair loss,the prevalence of family history or incidence of nail abnormalities and increase in serum IgE and eosinophils,between patients with atopic diseases and those without.ConclusionsThe expressions of filaggrin protein and mRNA are decreased in patients with AA,suggesting that filaggrin may participate in the development of AA and is correlated with the severity of AA.

Objective To detect the expressions of apoptosis-related factors and inflammatory cytokines in superficial and deep layers of as well as anagen hair follicles in lesions of early alopecia areata (AA).Methods Scalp biopsy samples were collected from 25 patients with early AA and 15 healthy human controls.Fluorescence-based quantitative PCR was performed to detect mRNA expressions of apoptosis-related genes p53,caspase 3,Fas,survivin and bcl-2,as well as those of inflammatory cytokines interleukin (IL)-4,IL-10,IL-12 and interferon (IFN)-γ.An immunohistochemical assay was conducted to measure the expression of p53 protein in anagen hair follicles.Results Compared with control skin samples,anagen hair follicles in AA lesions showed significantly increased mRNA expression levels (expressed as 2-△△Ct) of pro-apoptotic factors caspase 3,p53 and Fas (6.78,8.01,9.74,respectively,all P ＜ 0.05),but decreased mRNA expression levels of antiapoptotic factors bcl-2 and survivin (0.08 and 0.03 respectively,both P ＜ 0.01),and similar mRNA expression levels of inflammatory cytokines.There was a significant increase in mRNA expression levels of Th1 cytokines IFN-γ and IL-12 (2.75 vs.1.00,P ＜ 0.05; 85.67 vs.1.00,P ＜ 0.01),but a significant decrease in the expression level of the Th2 cytokine IL-10 (0.002 vs.1.000,P ＜ 0.01) in superficial layers of AA lesions compared with those of normal control skin.The degree of changes in mRNA expression levels of IL-10 and IL-12 was significantly higher in superficial layers than in deep layers of AA lesions (P＜0.01 and 0.05 respectively).The immunohistochemical assay showed that the number of p53-positive cells per 100 cells in anagen hair follicles of AA lesions was higher than that in those of control skin (t =23.79,P ＜ 0.01).Conclusions Anagen hair follicles in AA lesions exhibit high expressions of pro-apoptosis factors,but low expressions of antiapoptotic factors,suggesting that apoptotic factors play a role in the occurrence of AA.

Objective To observe the microstructural changes in lesions of alopecia areata (AA) with dermoscopy and to evaluate their correlation with clinicopathological manifestations. Methods The area of alopecia of 62 patients with AA and 44 patients with other types of hair loss were observed by using a noncontact polarized dermoscope (Dermlite, USA). Clinical data on and laboratory findings from these patients were collected. Pathological examination was carried out with scalp biopsy specimens from the alopecia area of 15 AA patients. Results Characteristic dermoscopic signs of AA included yellow dots, black dots, broken hairs, exclamation mark hairs, short vellus hair and newly-grown short hairs. Among these signs, yellow dots showed the highest prevalence (83.9%). Exclamation mark hairs, black dots and broken hairs were rather specific signs for AA, and the prevalence of the three signs was positively correlated with disease activity and positivity rate of hair-pull test. A positive correlation was also noted between the prevalence of elevated thyroid peroxidase antibody levels and positivity rate of hair-pull test (r = 0.269, P ＜ 0.05 ) as well as prevalence of broken hairs (r = 0.445, P ＜ 0.05), and between the prevalence of yellow dots and that of keratinous plug in follicular orifice. There was a negative correlation between the prevalence of newly-grown short hairs and perifollicular mast cell infiltration and between the prevalence of black dots and the anagen/catagen ratio. Conclusions Yellow dots can serve as a preliminary screening marker for AA. Exclamation mark hairs, black dots and broken hairs are highly sensitive for the confirmation of diagnosis of AA, and often predict progressive AA.Dermoscopic signs are well correlated to the histopathology features of AA, and may be useful for the evaluation of disease severity and guidance on the treatment of AA.

Objective To investigate the features of lymph node metastasis and its effects on the prognosis of patients after radical operation for thoracic esophageal squamous cell cancer, and investigate the reasonable postoperative adjuvant protocol. Methods Multivariate analysis of the clinical data of 204 patients was carried out by Spearman correlation analysis, Cox model and Kaplan-Meier method. Results The lymph node metastasis rate was 40.2% (82/204), and 166 out of 2193 dissected lymph nodes had metastasis with the rate of 7.57%. The analysis of related factors revealed that the invasion depth, tumor length and differentiation grade were significantly associated with the postoperative lymph node metastasis (χ2 = 17.466, 11.494, 6.767, P <0.05), while age, tumor site were not significantly correlated with the postoperative lymph node metastasis (χ2=1.086, 3.897, P > 0.05). Kaplan-Meier analysis showed that the 1-, 3-, 5-year survival rates of patients with < 4 lymph nodes metastasis were significantly higher than those with ≥4 lymph nodes metastasis (χ2=4.493, 4.494, 4.450, P < 0.05). The recurrence and metastasis were more often occurred in patients with lymph node metastasis compared with those without lymph node metastasis (r=-2.060, -4.296, P <0.05). Multivariate analysis confirmed that the pathological stage, tumor differentiation grade, and the postoperative adjuvant treatment were the independent prognostic factors. Conclusions The invasion depth, tumor length and differentiation grade are significantly associated with the postoperative lymph node metastasis. The lymph node metastasis state and the number of involved lymph nodes affect the prognosis of patients. Oral administration of 5-FU is benefit to the patients without lymph node metastasis.