1.Inadequate energy and protein supply in children undergoing cardiopulmonary bypass surgery:current problems and future direction
Jian ZHANG ; Yanqin CUI ; Zeming MA ; Yi LUO ; Xinxin CHEN ; Jia LI
Chinese Journal of Thoracic and Cardiovascular Surgery 2018;34(5):317-320
Objective It has been increasingly realized that perioperative nutritional support plays an important role in improving clinical outcomes in children with congenital heart disease ( CHD) undergoing cardiopulmonary bypass surgery.The purpose of this review was to examine the nutritional conditions in perioperative CHD children and the main problems in nutri-tional management in the cardiac intensive care unit ( CICU) , based on which further directions were proposed .We found that preoperative malnutrition is common .This limited research of energy and protein is further compounded by the complex meta-bolic alterations with hyper-metabolism, hyper-catabolism and hypo-anabolism in the early postoperative course.Knowledge a-bout energy and protein metabolism and requirements in post-CPB children remains much limited .The current nutritional rec-ommendations in the CICU are based on little evidence .Insufficient energy and protein supply to meet demands remains a norm in the immediate postoperative period .The commonly used predictive equations do not provide accurate estimate of energy re-quirement in individual patients during the highly dynamic postoperative course .Indirect calorimetry can provide the best esti-mate of energy requirements for CHD infants .Nitrogen balance is recommended to assess the minimal protein requirement . During the early postoperative period, daily measurements of resting energy expenditure using indirect calorimetry and nitrogen balance in each individual child are essential to optimize energy and protein supply to meet requirements .A paradigm should be shifted toward individualized nutrition prescription in the context of a specific CICU feeding algorithm .
2.Effects of sublingual immunotherapy on Treg/Th17 cell balance and related cytokines in preschool children aged 3-6 years with allergic rhinitis
Zebin JIANG ; Zeming MA ; Danjie WANG
Chinese Archives of Otolaryngology-Head and Neck Surgery 2024;31(1):36-40
OBJECTIVE To evaluate the impact of sublingual immunotherapy(SLIT)on the balance of Treg/Th17 cells and related cytokines in preschool children aged 3-6 years with allergic rhinitis(AR).METHODS Seventy preschool children aged 3-6 years with AR were divided into the SLIT group and the medication group,and their clinical data were retrospectively analyzed.The medication group received symptomatic treatment alone,while the SLIT group received a combined treatment of SLIT and symptomatic medication,with a 3-year follow-up period.The Treg/Th17 cell balance,serum levels of TGF-β,IL-10,IL-17,IL-21,as well as the total nasal symptom score(TNSS),total medication score(TMS),and visual analog scale(VAS)scores were compared before and after treatment between the two groups.RESULTS After 3 years of treatment,both groups showed significant improvements(P<0.05)in the percentages of CD4+CD25+Foxp3+Treg and CD4+IL-17+Th17 cells among CD4+T cells,percentages of Treg and Th17 cells,serum levels of TGF-β,IL-10,IL-17,IL-21,TNSS,TMS,and VAS scores.Moreover,the SLIT group exhibited significantly better outcomes compared to the medication group(P<0.05).CONCLUSION SLIT can modulate the balance of Treg/Th17 cells and improve serum levels of TGF-β,IL-10,IL-17,and IL-21.
3.Microsurgery techniques for insular glioma.
Mingyu ZHANG ; Lei HUO ; Junyu WANG ; Zhiming MA ; Jiasheng FANG ; Yihua RAO ; Zeming TAN ; Zhenxing ZHANG
Journal of Central South University(Medical Sciences) 2009;34(4):345-348
OBJECTIVE:
To explore the microsurgical techniques for insular glioma without damaging its surrounding normal structures.
METHODS:
We retrospectively analyzed 54 patients with insular gliomas who underwent microsurgical operation by trans-syvian fissure approach between May, 2003 and August, 2008 in Xiangya Hospital. We discussed the techniques in the operation and summarized how to protect the key blood vessels, distinguish and protect the surrounding normal structures.
RESULTS:
There were 36 complete removals,14 secondary complete removals, and 4 partial removals.Six patients had complications after the craniotomy who had temporal speech disorder (aphasia mostly began to recover about 10 days after the craniotomy),4 patients had opposite side paralysis worsening (3 recovered normally and 1 improved after 6 months),4 had light paralysis, and another 3 had paralysis and speech disorder.
CONCLUSION
The microsurgery by means of trans-syvian fissure approach can well expose the anatomical relation between tumor and its surrounding structures,so that we can remove the tumor and protect the surrounding normal tissues as much as we can.
Adolescent
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Adult
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Brain Neoplasms
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pathology
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surgery
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Cerebral Cortex
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pathology
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surgery
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Female
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Glioma
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pathology
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surgery
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Humans
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Male
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Microsurgery
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methods
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Middle Aged
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Neurosurgical Procedures
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methods
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Retrospective Studies
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Young Adult
4.Chondrosarcoma original from the zygomatic arch: A case report and literature review.
Xinqi FANG ; Ying WANG ; Yujie MA ; Zeming TAN ; Jun WU
Journal of Central South University(Medical Sciences) 2019;44(6):720-724
Chondrosarcoma original from the zygomatic arch is a very rare disease with high malignancy. Surgery is the main means of treatment at present for duo to its poor sensitivity to radiochemotherapy. We reported a young patient who was recovery well in a 4-years follow-up without radiochemotherapy after a total resection of the tumor.
Bone Neoplasms
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Chemoradiotherapy
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Chondrosarcoma
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Humans
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Self Concept
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Zygoma
5.APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation.
Hongkai ZHAO ; Kuan YANG ; Yiyuan ZHANG ; Hongyu LI ; Qianzhao JI ; Zeming WU ; Shuai MA ; Si WANG ; Moshi SONG ; Guang-Hui LIU ; Qiang LIU ; Weiqi ZHANG ; Jing QU
Protein & Cell 2023;14(12):908-913
6.mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells.
Qun CHU ; Feifei LIU ; Yifang HE ; Xiaoyu JIANG ; Yusheng CAI ; Zeming WU ; Kaowen YAN ; Lingling GENG ; Yichen ZHANG ; Huyi FENG ; Kaixin ZHOU ; Si WANG ; Weiqi ZHANG ; Guang-Hui LIU ; Shuai MA ; Jing QU ; Moshi SONG
Protein & Cell 2022;13(9):676-682
7.Correction to: mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells.
Qun CHU ; Feifei LIU ; Yifang HE ; Xiaoyu JIANG ; Yusheng CAI ; Zeming WU ; Kaowen YAN ; Lingling GENG ; Yichen ZHANG ; Huyi FENG ; Kaixin ZHOU ; Si WANG ; Weiqi ZHANG ; Guang-Hui LIU ; Shuai MA ; Jing QU ; Moshi SONG
Protein & Cell 2022;13(12):961-961