OBJECTIVETo examine serum IL-2 and IL-6 levels in BMS patients with or without depression and make clear the relationship between serum IL-2, IL-6 and mood disorder.

METHODSSerum IL-2 and IL-6 were examined in 48 BMS patients by means of ELISA. The Hamilton Depression Rating Scale (HDRS) was used to evaluate the depressive symptomatology.

RESULTSThere was no significant difference in serum IL-2 and IL-6 among BMS patients with or without depression. Mood disorder was not correlated to serum IL-2 and IL-6, but positively correlated to pain levels.

CONCLUSIONDepression status may not influence serum IL-2 and IL-6 levels significantly, but it has a relationship with BMS. The HDRS can be used to determine depression status in BMS patients in order to help clinical treatment.

Adult ; Aged ; Aged, 80 and over ; Burning Mouth Syndrome ; blood ; psychology ; Depressive Disorder ; blood ; psychology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Interleukin-2 ; blood ; Interleukin-6 ; blood ; Male ; Middle Aged ; Pain Measurement ; Psychiatric Status Rating Scales