1.Study on the effects of FCu-IUD and FICu-IUD on matrix metalloproteinases in human uterine flushing and endometrium.
Wei, LI ; Lumin, CAO ; Zaojao, CHEN ; Wan, LI ; Qingling, DU ; Guiping, CHEN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2002;22(1):9-11, 16
The activity of matrix metalloproteinases (MMPs) in the uterine flushing and endometrial tissue of normal adult women wearing FCu-IUD (fixed Cu-IUD) or FICu-IUD (indomethacin-releasing FCu-IUD) was observed by using zymography on SDS-PAGE containing gelatin. The results showed that the activity and kinds of MMPs in FCu-IUD group were increased significantly as compared with themselves before being inserted FCu-IUD. However, compared with the FCu-IUD group, the activity of some kinds of MMPs in the FICu-IUD group was decreased significantly. These data suggest that IUD can enhance the activity of MMPs in human endometrium, intermediated by prostaglandins, and MMPs may have relation to IUD-induced menorrhagia and indomethacin reduces IUD-induced menorrhagia by partly inhibiting MMPs synthesis.
Endometrium/*enzymology
;
Indomethacin
;
Intrauterine Devices, Copper/*adverse effects
;
Intrauterine Devices, Medicated/*adverse effects
;
Matrix Metalloproteinases/*metabolism
;
Uterine Hemorrhage/etiology
;
Uterine Hemorrhage/prevention & control
2.Study on the effects of FCu-IUD and FICu-IUD on matrix metalloproteinases in human uterine flushing and endometrium.
Wei LI ; Lumin CAO ; Zaojao CHEN ; Wan LI ; Qingling DU ; Guiping CHEN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2002;22(1):9-16
The activity of matrix metalloproteinases (MMPs) in the uterine flushing and endometrial tissue of normal adult women wearing FCu-IUD (fixed Cu-IUD) or FICu-IUD (indomethacin-releasing FCu-IUD) was observed by using zymography on SDS-PAGE containing gelatin. The results showed that the activity and kinds of MMPs in FCu-IUD group were increased significantly as compared with themselves before being inserted FCu-IUD. However, compared with the FCu-IUD group, the activity of some kinds of MMPs in the FICu-IUD group was decreased significantly. These data suggest that IUD can enhance the activity of MMPs in human endometrium, intermediated by prostaglandins, and MMPs may have relation to IUD-induced menorrhagia and indomethacin reduces IUD-induced menorrhagia by partly inhibiting MMPs synthesis.
Adult
;
Endometrium
;
enzymology
;
Female
;
Humans
;
Indomethacin
;
Intrauterine Devices, Copper
;
adverse effects
;
Intrauterine Devices, Medicated
;
adverse effects
;
Matrix Metalloproteinases
;
metabolism
;
Middle Aged
;
Uterine Hemorrhage
;
etiology
;
prevention & control