Objective:To explore the effect of early cognitive rehabilitation combined with music therapy on cognitive function, activities of daily living (ADL) and psychology in stroke patients. Methods:From March, 2016 to September, 2017, 56 stroke patients were were randomly divided into control group (n = 28) and observation group (n = 28). All the patients accepted early motor and cognitive rehabilitation, the observation group accepted music therapy in addition, for four weeks. They were assessed with Mini-Mental State Examination (MMSE), Loewenstein Occupational Therapy Congnitive Assessment (LOTCA), modified Barthel Index (MBI), Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS). Results:The scores of MMSE, scores of subscales and total scale of LOTCA, and MBI increased in both group after treatment (t > 5.480, P < 0.05), while the scores of SAS and SDS decreased (t > 10.227, P < 0.001). The total scores of MMSE, LOTCA and MBI increased more (t > 2.648, P < 0.05), and the scores of SDS decreased more (t = 2.818, P < 0.05) in the observation group than in the control group. Conclusion:Combination of music therapy may promote the recovery of cognitive function, ADL and mental health for stroke patients.