Sen gai plant (Zanthoxylum alatum Roxb) belongs to Rutaceae family, was used commonly in India, China, Vietnam as restorative, increasing blood flow, sweat, treating rheumatisms and liver diseases. β-sitosterol, stigmasterol, β-sitosterol-3-O-β-glucopyranosid, vitexin and isovitexin were isolated from leaves of Zanthoxylum alatum Roxb in Vietnam by column chromatography. Chemical structures of these compounds were identified by spectroscopic methods (MS, 1H, 13C NMR and DEPT)
Steroids ; Flavonoids ; Zanthoxylum

Study on chemical coposition of essential oil from Zanthoxylum nitidum fruit collected at Me Linh district, Vinh Phuc province by GC/MS method. Results: the yield of essential oil from fruit was 0.35% by air-dry material, 27 constituents were identified, in which the main constituents were linalool L. (72.17%) and sabinen (11.24%)
chemistry ; Oils, Volatile ; Zanthoxylum

The determination of the contents and chemical components essential oil of Sen hoi (Zanthixylum rhetsa Roxl DC) collected in Mai Chau, Hoa Binh provine in Feb 2003 showed that the essential oil content reached 9,6% of dry product and 24 compouds was identified, among then the main compounds are benzen derivatives, 1- methoxy-4 (1- propenyl), benzaldehyd-4-methoxy, 1-butanon, 1- (4- hydroxy phemyl) and benzen-e,ethanol, alpha-ethyl-4-4 methoxy
Chemistry ; Oils, volatile ; Zanthoxylum

Luong dien huong (Zanthoxylum Syzygium aromaticum) is discounted by fruit of Luong dien cham (Zanthoxylum) and bud of dinh huong (Syzygium aromaticum). Study on experimentation and clinical on 64 inflamatgingival and periodontitis patients from 20-60 years old treated in the Institute No103, from August 2002 to June 2003. Patients is divided into 2 groups: N1: 32 patients treated with LDH and N2: 32 patients treated with RK94 drug. The results showed that: Luong dien huong have clearly antiflammation effect as lessen inflamatgingival, increase on stable of tooth and lessen the deep of inflamatgingival. The results of treatment with inflamatgingival, periodontitis is: 68.75% good, 25% middle, 6.25% bad, similarly with RK94 drug (6.25% good, 28.1% middle and 6.25% bad)
Periodontitis ; Therapeutics ; Zanthoxylum ; Eugenia ; Gingivitis

Ten compounds were isolated from the methanol extract of Zanthoxylum nitidum through silica gel, Sephadex LH-20, RP-18 and HPLC chromatography techniques. Their structures were elucidated by the MS and NMR spectra as zanthonitidine B(1), cyclo-(Leu-Leu-Leu-Leu-Ile)(2),6S-10-O-demethylbocconoline(3), liriodenine(4), isoplatydesmine(5), 5, 5'-dimethoxylariciresinol(6), syringaresinol (7), episyringaresinol (8), marmesin (9) and syringaldehyde (10). Among them,1 is a new alkaloid,2 is a cyclopentapeptide isolated from plant kingdom for the first time, and 3 is from the genus Zanthoxylum for the first time. Compounds 3 and 4 exhibited cytoxoxicity against three human cancer cell lines HT29, A549 and MDA-MB-231 with IC₅₈ values of 27.37, 24.10, 33.58 μmol·L⁻¹ and 9.12,6.05, 11.35 μmol·L⁻¹, respectively.
Alkaloids ; Chromatography, High Pressure Liquid ; Humans ; Zanthoxylum

OBJECTIVETo study the chemical constituents from the stems of Zanthoxylum dissitum.

METHODColumn chromatography on macroporous resin and silica gel, and spectral analysis were used to isolate and elucidate the constituents.

RESULTSeven compounds were isolated and identified as 5,8-dimethoxyethane-3,4-epoxy-furanocoumarin (1), isoimpinellin (2), beta-sitosterol (3), lupeol (4), neohesperidin (5), beta-daucosterol (6), ursolic acid (7).

CONCLUSIONAll above the compounds were isolated from the plant for the first time and the compound 1 is a new compound.

OBJECTIVETo establish the characteristic fingerprint of Zanthoxylum nitidum by HPLC, and to provide a reference for the quality control of Z. nitidum in the market.

METHODThe established HPLC characteristic fingerprint of Z. nitidum, combined with similarity evaluation and system clustering analysis method, were applied to distinguish 25 batches of samples purchased from market preliminarily, to identify the authenticity and quality of Z. nitidum ingredients.

RESULTIn the 25 batches of samples purchased from market, only 8 batches were identified as genuine with good quality, 7 batches were identified as defective, 7 batches were identified as common counterfeit Toddalia asiatica, and 3 batches were identified as counterfeit.

CONCLUSIONThis method is accurate, convenient and reliable. It can be used for identification and quality control of Z. nitidum ingredients.

Phenylpropanoids are one of the major chemical constituents in Zanthoxylum species. They include simple phenylpropanoids, coumarins, and lignans and possess anti-tumor, anti-inflammatory, anti-platelet aggregation, anti-bacterial, anti-viral, insecticidal, and antifeedant activities. This review summarizes the chemical constituents and pharmacological activities from the Zanthoxylum plants in hopes of providing reference for the research and application of phenylpropanoids from this genus.
Anti-Inflammatory Agents/pharmacology* ; Coumarins/pharmacology* ; Lignans ; Plant Extracts ; Zanthoxylum

Zanthoxylum belongs to the Rutaceae family, and there are 81 Zanthoxylum species and 36 varieties in China. Most of the Zanthoxylum plants are used as culinary spice. In recent years, scholars in China and abroad have carried out in-depth research on Zanthoxylum plants, and found that the peculiar numbing sensation of Zanthoxylum plants originates from amides. It is also determined that amides are an important material basis for exerting pharmacological effects, especially in anti-inflammatory analgesia, anesthesia and other aspects. In this paper, 123 amides in 26 Zanthoxylum plants and their pharmacological activity that have been reported were summarized, which provided scientific reference for the clinical application of Zanthoxylum plants and the research and development of new drugs, and also facilitated the sustainable development and utilization of Zanthoxylum plant resources.
Zanthoxylum/chemistry* ; Amides/chemistry* ; Plant Extracts/pharmacology* ; China

This study aimed to investigate the transdermal enhancing effect of essential oil from Zanthoxylum bungeanum(Z. bungeanum oil) in microemulsion gel(ZO-ME-gel) on permeation of different components,and reveal the transdermal enhancing mechanism of ZO-ME-gel. A series of components with different log P values were selected as model drugs and encapsulated in ZO-ME-gel to simplify and characterize the complex components of traditional Chinese medicine. The transdermal behavior of the model drugs was further examined using the improved Franz diffusion cell method. Then attenuated total reflection Fourier transform infrared spectroscopy(ATR-FTIR),differential scanning calorimetry(DSC) studies and hematoxylin-eosin(HE) staining were used to investigate the effects of Z. bungeanum oil and ZO-ME-gel on keratin,intercellular lipids and microstructure of the stratum corneum(SC). The results showed that Z. bungeanum oil and ZO-ME-gel had a good transdermal enhancing effect on both hydrophilic and lipophilic drugs,and the best effect was achieved when log P value was-0. 5. The transdermal enhancing mechanism of Z. bungeanum oil and ZO-ME-gel was related to affecting the order of the SC lipids,changing lipid fluidity and protein conformation,and disrupting the integrity of the SC structure. 5% Z. bungeanum oil had greater transdermal enhancing effect and destruction of SC structure than ZO-ME-gel. These results suggested that Z. bungeanum oil loaded in microemulsion gel still had a good transdermal enhancing effect although the effect was not as great as Z. bungeanum oil itself,in addition,ZO-ME-gel was less irritating to the skin and safer to use,which had a guiding role in the development and clinical application of Z. bungeanum oil-containing traditional Chinese medicine topical preparations.
Administration, Cutaneous ; Oils, Volatile ; Skin ; Skin Absorption ; Zanthoxylum