Objective: To analyze the nursing methods and effects of early rehabilitation and health management for hypertensive patients with cerebral infarction and hemiplegia. Methods: Totally 86 patients with hypertension and cerebral infarction with hemiplegia were randomized to a random number table, with 43 patients in each group. The control group received routine nursing, and the observation group underwent early rehabilitation health management care, and the recovery of the two groups was compared. Results: After treatment, the patient medical research committee score (MRC) in the observation group was (50.25±3.37) points, higher than the control group (40.28±3.38) points, and the Fugl-Meyer score (upper limb) of the observation was (65.44 ± 1.08) points, which was higher than that of the control group (53.38 ±1.22) points, and the Fugl-Meyer score (lower limb) was (28.15±1.13) points, significantly higher than the control group (26.52±1.17) points, the living activity ability Barthel index (88.65±4.73) was significantly higher than the control group (80.27 ±4.69)( t values were 6.571-48.536, P < 0.01). After nursing, the scores of memory and thinking, emotion, communication, mobility, daily living ability, hand function, strength and participation in the quality of life in the observation group were (74.58 ±3.27) points, (75.87 ±4.06) points, (72.31 ±5.08) points, (72.13 ±5.06) points, (69.75 ±4.41) points, (78.56 ±5.13) points, (64.17±3.50) points and (68.95±5.03) points. The scores of the observation group were significantly higher than those of the control group, which were (69.27 ±3.66) points, (66.35 ±4.17) points, (63.59±5.41) points, (58.95±4.22) points, (59.67±4.30) points, (63.49±5.07) points, (59.74±3.15) points, (54.09±5.10) points (t values were 6.144-13.701, P < 0.05). Conclusion Early rehabilitation health management and nursing for hypertensive patients with cerebral infarction and hemiplegia is helpful to improve the limb motor function and life activity ability of patients, and can significantly improve the quality of life of patients, which is worthy of promotion.