AIMTo observe the effect of rhubarb ethanol-extract on hyperlipidemia and liver fatty in rabbits.

METHODSThirty healthy male white rabbits were divided randomly into five groups, six rabbits in each group. The rabbits in control group were fed with common forage. The rabbits in model group were fed with high lipid forage. The rabbits in three different rhubarb groups were fed with high lipid forage and treated with different level rhubarb ethanol-extract (REE). In the process of experiment, periodically measured serology index of the rabbits and observed common physiology index. The rabbits were killed at the end of tenth week, liver fatty degeneration degree and liver coefficient were measured and compared.

RESULTSREE could decrease serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), and increase serum high density lipoprotein cholesterol (HDL-C), and reduce liver fatty de generation and protect liver cell function. And the dose-effect relation was showed among different dose REE groups.

CONCLUSIONREE can significantly reduce blood lipid, prevent and treat hyperlipidemia and liver fatty.

Animals ; Ethanol ; Fatty Liver ; drug therapy ; pathology ; Hyperlipidemias ; blood ; drug therapy ; Lipids ; blood ; Liver ; drug effects ; Male ; Plant Extracts ; pharmacology ; Protective Agents ; pharmacology ; Rabbits ; Rheum