Bleeding disorders, including hemophilia, can be seen in every ethnic population in the world. Among various bleeding disorders, reduced bone density has been addressed in hemophilia A. In recent years, there has been an increasing interest in addressing osteopenia and osteoporosis in hemophilia A. There is little or no study about the possible susceptibility of other individuals with bleeding disorders to reduced bone density. Questions have been raised about the role of blood coagulation factors in bone mineralization. This review provides new insight and ideas for further survey in the field of bleeding disorders and reduced bone density.
Blood Coagulation Factors ; Bone Density* ; Bone Diseases, Metabolic ; Calcification, Physiologic ; Hemophilia A ; Hemophilia B ; Hemorrhage* ; Osteoporosis ; von Willebrand Diseases