Objective: To investigate the proportion of high-risk population for cardiovascular diseases (CVD) among residents at ages of 35 to 79 in Nanjing City, and establish a prediction model of high-risk population for CVD. Methods: Residents at ages of 35 to 79 years were selected from Nanjing City using a multi-stage stratified cluster random sampling method from 2020 to 2021. Participants' demographic information, characteristics of lifestyle and blood biochemical index were collected using questionnaire surveys, physical examination and laboratory testing. The high-risk population for CVD were determined according to the Chinese Guidelines for Cardiovascular Disease Risk Assessment and Management, and the Chinese Guidelines for the Prevention and Treatment of Adult Dyslipidemia (2016 Revision). Predictive factors for high-risk population for CVD were screened using a multivariable logistic regression model. A nomogram was established and verified with receiver operation characteristic (ROC) curve. Hosmer-Lemeshow goodness of fit test was used to evaluate the fitting effect and Bootstrap method was used for internal verification. Results: A total of 38 428 individuals were surveyed, including 17 970 males (46.76%) and 20 458 females (53.24%), and 25 714 individuals aged 35 to 59 years. There were 8 905 high-risk population for CVD, with a detection rate of 23.17%. Multivariable logistic regression analysis identified 9 factors affecting high-risk population for CVD. A prediction model was established for ln[P/(1-P)]=-7.305+2.107×age-0.366×gender+0.299×marital status-0.297×educational level+0.631×body mass index+0.013×sleep duration+0.096×edible salt intake+0.444×smoke-0.069×alcohol consumption. The area under ROC curve was 0.799 (95%CI: 0.794-0.805), the sensitivity and specificity were 0.731 and 0.753, indicating good differentiation. The nomogram based on the above factors indicated good calibration and stability. Conclusion The nomogram constructed by age, gender, marital status, educational level, body mass index, sleep duration, edible salt intake, smoking and alcohol consumption can be used to predict high-risk population for CVD.

Objective To explore the effects of mirror therapy on the lower-limb muscles of hemiplegic stroke survivors. Methods Sixty-two hemiplegic stroke survivors were divided by stratified random grouping into a mirror group and a control group, each of 31. Both groups accepted routine rehabilitation training, while the mirror group was additionally provided with mirror therapy to train the non-paretic limb for 30 min per day, 5 days a week, lasting 4 weeks. Before and after the 4 weeks of training, integrated electromyography was performed and the maximum voluntary contraction force (MVC) of the tibialis anterior, rectus femoris and biceps femoris of the paretic limb were recorded and compared. Results Compared with before the training, the average root mean square values of the electromyographs and the average MVCs of all three muscles had improved significantly in both groups after training. Compared with the control group, the improvements were significantly greater in the mirror group. Conclusion Mirror therapy can promote the activation and synchronization of motor units, as well as increase the number discharging and the total discharge, promoting the recovery of muscle strength.

Objective:To evaluate the efficacy and safety of a China original liquid pulsation system for the treatment of meibomian gland dysfunction (MGD).Methods:A non-randomized controlled clinical trial was conducted.Twenty-two patients (44 eyes) diagnosed with MGD in Eye and ENT Hospital of Fudan University from February to August 2022 were enrolled.The patients were assigned into two groups according to their willingness.Of the 22 patients (44 eyes), 10 patients (20 eyes) in single liquid pulsation system group were treated with single liquid pulsation system for 12 minutes, and 12 patients (24 eyes) in intense pulsed light (IPL) group were treated with a course (4 times) of IPL, warm compresses and meibomian gland massage at three-week intervals.There was no difference in age and other baseline clinical indexes between the two groups (all at P<0.05). The meibum grading, quality grading of tear film lipid layer, Symptom Assessment Questionnaire in Dry Eye (SANDE) questionnaire score, first and average tear breakup time (BUT), corneal fluorescein sodium staining (CFS) score, tear meniscus height (TMH), and the area of meibomian gland loss were determined at baseline, 1 and 3 months after treatment.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Eye and ENT Hospital of Fudan University (No.2021069). Written informed consent was obtained from each patient before any medical examination. Results:Statistically significant group effects and time effects were found in the quality of tear film lipid layer ( Hgroup=4.39, P=0.036, Htime=6.30, P=0.043) and average BUT ( Fgroup=4.41, P=0.038; Ftime=4.08, P=0.049) in the two groups.The meibum grading, first BUT and TMH 1 and 3 months after treatment were significantly better than before treatment in single liquid pulsation system group (all at P<0.05). Compared with before treatment, there was no significant improvement in the meibum grading, distribution of tear film lipid, first BUT and TMH at 1 and 3 months after treatment in IPL group (all at P>0.05). In both groups, the SANDE and CFS scores 1 and 3 months after treatment were better than those before treatment, showing statistically significance (all at P<0.05). In terms of safety, neither instrument-related adverse events nor extra complaints of discomfort were reported in the single liquid pulsation system group.In both groups, the number of patients with positive CFS staining significantly decreased, and no new cases with positive CFS appeared after treatment. Conclusions:This China original liquid pulsation system is a safe and effective physical therapy in improving tear film dysfunction and ocular surface symptoms of MGD patients within 3 months after treatment.