Hepatorenal Syndrome ; diagnosis ; prevention & control ; therapy ; Humans ; Liver Transplantation

Humans ; Liver Failure, Acute ; etiology ; therapy

Adult ; Humans ; Liver Transplantation ; United States

Objective Good culture sense of patient safety among the hospital staff is in close relation with the improvement of medical quality and patient safety .The article was to provide evidence for the culture management of patient safety and related stud -ies.Methods We searched the main databases Pub Med , Chinese Bio-medical Literature Database , CNKI, Wan-Fang database with the key word safety environment,safety culture,safety approach,evaluate,assessment,situation analysis,analy-sis. Results 50 literatures were collected.The assessment tools could be divided into self-made questionnaire (13, 26%), im-proved questionnaire (16, 32%), chineselized foreign questionnaire (21, 42%).The main researchers (84%) and study objects (66%) were nurses.48 (96%) investigation and descriptive study were about patient safety culture;only 2 documents made compari-son before and after the patient safety culture cultivation . Conclusion The research of patient safety culture in our country is rising currently, while the development of assessment tools is still at exploration stage .The width and depth of related research should be fur-ther broadened .

0 05).Plasma ET in the active LN was significantly higher than that in the inactive LN and normal control group ( P

Objective: To analyze the Effect of rt-PA thrombolytic therapy on elderly patients with cerebral infarction. Methods: Chosen elderly patients with cerebral infarction between November 2012 to November 2013 as study object, randomly divided into observe group receive rt-PA thrombolytic therapy and control group receive aspirin and Batroxobin, detecting neurological impairment, physical function score and adverse treatment outcomes. Results: 1)before thrombolytic treatment, neurological deficit situation of two groups were no significant difference (P>0.05), after treatment, observation group patients’ neurological deficit scores were significantly lower than control group at each time point (P<0.05); 2)after treatment, limb function defective number of observation group patient was significantly less than observation group(P<0.05); 3)after treatment, observation groups’ adverse outcomes as again infarction, large area cerebral hemorrhage after thrombolysis, plant survival, incidence of death was significantly lower than control group (P<0.05). Conclusion: The injection of rt-PA thrombolytic therapy can significantly optimize neurological and physical function in patients , reducing the incidence of adverse treatment outcomes, with positive clinical significance.

AIM:To observe the effects of Huoxue-Yiqi-Bushen prescription on the hemorrheological parame-ters and endothelial nitric oxide synthase ( eNOS) activity in the aged patients with hip arthroplasty at postoperative period. METHODS:The patients ( n=60) operated by the same group of doctors were randomly divided into traditional Chinese medicine ( TCM) group, low-molecular-weight heparin ( LMWH) group and control group.Postoperative patients in TCM group were administrated with Huoxue-Yiqi-Bushen prescription.In LMWH group, 20 patients received LMWH postopera-tively.The patients in control group took aspirin enteric-coated tablets.The eNOS activity, nitric oxide (NO) content and hemorrheological parameters were observed before operation and 1 d and 10 d after operation.RESULTS: No significant difference of eNOS activity, NO content, whole blood viscosity (WBV), plasma viscosity (PV), hematocrit (HCT), erythrocyte aggregation index ( EAI) , index of rigidity ( IR) , erythrocyte deformation index ( EDI) and erythrocyte electro-phoresis time (EET) between 3 groups 1 d after operation was found, while significant difference (P<0.01) appeared be-tween TCM group and control group 10 d after operation.CONCLUSION:Huoxue-Yiqi-Bushen prescription can effective-ly increase eNOS and NO levels and improve hemorrheological parameters at postoperative period in aged patients with hip arthroplasty.

Objective To study the cognition of scientific research integrity and know status of scientific research standard of nurses who had research experience so as to provide some evidence for nursing research integrity management.Methods A total of 296 nurses whose working years was more than 5years and who had delivered scientific research papers in 13 Grade A hospitals from 7 cities were investigated by self-designed questionnaires.Results More than 64.0％ nurses showed not appropriate or inappro-priate for those irresponsible research behavior.64.5％ nurses did not agree with the researchers to referring the research object situation for others,97.0％ nurses believed the research achievement should be objective.While nurses did not know the research standards well:only 56.1％ nurses knew the standard of submitting manuscript,and 20.6％ nurses knew research data collection,preservation and usage.Conclusions It is necessary to enhance the management of nursing research integrity through education and propaganda of the research standards,improving the scientific management system,increasing the research support for nurse scientific so as to promote the nursing research integrity.

Objective:To investigate the clinical efficacy of honeysuckle extraction liquid combined with nasal irrigation in the treatment of nasosinusitis after radiotherapy of nasopharyngeal carcinoma.Methods:Eighty-two patients with nasosinusitis post-radiotherapy who received treatment between February 2018 and February 2020 in the First Hospital of Jiaxing were included in this study. They were randomly assigned to receive either nasal irrigation with 0.9% sodium chloride injection (control group, n = 41) or atomization treatment with honeysuckle extract liquid plus nasal irrigation with 0.9% sodium chloride injection (observation group, n = 41), once daily for 4 successive weeks. Visual Analogue Scale (VAS) and nasal endoscopic Lund-Kennedy (LK) score, ciliary transport rate, clinical efficacy and adverse reactions were compared between the control and observation groups. Results:After treatment, the nasal congestion score [(0.82 ± 0.10) points], viscous or purulent nasal discharge score [(1.88 ± 0.25) points], olfactory dysfunction score [(1.12 ± 0.15) points], head and face pain score [(0.40 ± 0.06) points] and nasal endoscopic Lund-Kennedy score [(2.03 ± 0.26) points] in the observation group were significantly lower than those in the control group [(1.94 ± 0.26) points, (2.93 ± 0.37) points, (1.73 ± 0.25) points, (0.62 ± 0.09) points, (4.07 ± 0.47) points, respectively, t = 9.156, 15.056, 13.397, 13.023, 9.156, all P < 0.01]. The ciliary transport rate in the observation group [(4.71 ± 0.56) mm/min] was significantly higher than that in the control group [(3.94 ± 0.51) mm/min, t = 15.056, P < 0.01]. Total effective rate in the observation group was 97.56% (40/41), which was significantly higher than 80.49% (33/41) in the control group ( χ2 = 4.493, P < 0.05). In the control group, one patient had epistaxis, and no adverse reaction was observed in the observation group. Conclusion:Honeysuckle extraction liquid combined with nasal irrigation with 0.9% sodium chloride injection is effective in the treatment of nasosinusitis after radiotherapy for nasopharyngeal carcinoma, can greatly improve the symptoms and signs of patients, and is highly safe.

The incidence of malignancy tumors has increased significantly recent years in patients with type 2 diabetes mellitus (T2DM).As the first-line oral medicine of T2DM,in addition to the safe and effective hypoglycemic effect,metformin can reduce the incidence and mortality of cancer,and improve the prognosis in T2DM patients.While the exactly anti-tumor mechanisms of mefformin is not yet clear,which might be the inhibition of proliferation and promotion of apoptosis of tumor cells mainly by acting on an adenosine monophosphate activated protein kinase (AMPK) and microRNAs (miRNAs).And metformin can inhibit migration and invasion of tumor cells,as well as strengthen the effects of chemotherapy drugs.This article reviews the recent research progress of clinical and epidemiological studies and anticancer mechanisms of metformin.