Systemic lupus erythematosus is an autoimmune-mediated inflammatory diseases in which immunologic derangement throughout this process.There are a varriety of abnormal immunoregulation,including the disturbance of Help T cell 1,Help T cell 2,Th17 cell and regulatory T cell( Treg cell),disfunction of the B cell subsets and deficiency of the immune tolerance,lead to the disturbance of related cytokines.Recently,it was indicated that the abnormal of cross regulation existencd between Help T cell 1 and Th17 cell,and the disfunction of non-antibody-dependent B cells may play an important role in the pathogenesis of SLE,According to different immune status,appropriate and targeted treatment was given in order to improve the prognosis of the patients with systemic lupus erythematosus.

Objective:To evaluate the clinical efficacy of telmisartan in patients with mild to moderate hypertension by observing the 24 hour mean blood pressure before and after treatment respectively.Methods:Twenty-six patients with mild to moderate hypertension took telmisartan 80mg once daily.After the treatment of telmisartan,ambulatory blood pressure monitoring (ABPM) was done.Results:After administration of telmisartan,24 hour mean blood pressure,blood pressure in the day and night decreased(P

Objective:Assessment ofthe value of B-type natriuretic peptide levels combines TIMI risk scores in predictinglate mortality in patients with ST-segment Elevation Myocardial Infarction(STEMI).Methods:345 patients with STEMI were studied.Blood was drawn and the plasma concentration of BNP was determined within 24 hours after the onset of chest pain and the patients'TIMI risk score was measured.The all-cause mortality,including cardiac and non-cardiac deaths during Long-term follow-up,was recorded.Results:Mortality was 20.0%(n=69)during a follow-up of 314?208 days.The late mortality was related to higher TIMI risk scores(P;P

Microorganism distributes in the organs of human body which connect with external environment, especially those organs in the gastrointestinal tracts, and it also plays a fundamental role in the physiopathology of the host's body. Because the microorganism is very small and has a great variety, it is difficult to reveal the significance of microorganism in the human physiopathology comprehensively and deeply. With the development of molecular biology, genomics, bioinformatics and other disciplines, the microbiome research will be more possible and easier. There are two key contents of microecology. One of these is to identify and quantify the diversity of microorganism, and the other is to reveal activity and the physiopathological function of microorganism in the host. Microbiome research methods, therefore, can be summarized as the traditional detection methods, construction of gene library, the genetic fingerprint analysis and molecular hybridization techniques and so on.
Computational Biology ; Gastrointestinal Microbiome ; Gastrointestinal Tract ; microbiology ; Humans

The condition and prognosis of ischemic cerebrovascular disease(ICVD)are closely associated w ith the w hole blood coagulation status and the reactivity of antiplatelet agents of patients. Thromboelastography ( TEG ) is a reliable means to detect the w hole blood coagulation and fibrinolytic capacity. Its overal results of the evaluation can be used in the coagulation monitoring, efficacy of antiplatelet therapy, and prognostic evaluation in patients w ith ischemic cerebrovascular disease. In recent years, the detection methods of TEG have been improved continuously. The research reports for its clinical application are gradual y increasing. This article review s the clinical application of TEG in the diagnosis, treatment, and prognostic evaluation in ischemic cerebrovascular disease.

Objective To implement the informationization management in 80% medical treatment health vocation through the research of clinical information exchange and share system,and truly realize "patient as central" in comprehensive information management. Methods The theories and ways for system engineering and management information system were used and succeed experience of domestic and overseas were referenced by the middleware added to system. Results The clinical information exchange system can accelerate medical treatment decision and promote efficiency and level of management,and cut down cost of medical treatment,which can improve clinical scientific research in further. Conclusion This research not only has practical importance,but also embodiment advancement,prospective,operability and latent social benefit.

Objective: To investigate the effect of vascular endothelial growth factor-C (VEGF-C) on invasive capability and proliferation of human cholangiocarcinoma cells. Methods: The effect of VEGF-C on FRH0201 was assayed by MTT. The cycle pattern and apoptosis was assayed using flow cytometry. The effect of VEGF-C on homotypic adhesion and metastasis in FRH0201 was examined with 3H-TdR infiltration and Boyden chamber. Results: VEGF-C could enhance the proliferation of FRH0201 in a dose and time dependent manner. And VEGF-C could inhibit cell apoptosis significantly. After cultured for 2 hours with 1, 5, 10ng/ml of VEGF-C, there were more cells in the lower chamber than the control group. After 60, 90, 120 minutes induction by 1ng/ml、5ng/ml、10ng/ml, the cells showed significantly lower homotypic adhesion than that of the control group. Conclusions: VEGF-C could enhance the proliferation of FRH0201 and inhibit cell apoptosis. VEGF-C could decrease homotypic adhesion of FRH0201 and might be a cause of the metastasis.

Atherosclerosis,as a chronic inflammatory vascular disease,involves many cellular and molecular events in its formation and progression from an early fatty streak lesion to a highly dangerous rupture-prone plaque.The vulnerability or destabilization of atherosclerotic plaques is closely associated with plaque composition.Such imaging modality as magnetic resonance imaging(MRI),which allows of the evaluation of the plaque composition at the cellular and molecular level,may differentiate vulnerable and destabilized plaques and monitor the efficacy of antiatherosclerotic therapies.This paper gives an overview of molecular imaging strategies currently used for targeting the inflammation markers of atherosclerotic plaque vulnerability.

Humans ; Maxillary Sinus Neoplasms ; pathology ; Myoepithelioma ; pathology ; Paranasal Sinuses ; pathology

After cataract,called posterior capsule opacification (PCO),is resulted from residual cortex or the proliferation of lens epithelial cells following extracapsular cataract extraction,and it is thought to be themost common complication and the main reason of eyesight decline after modern extracapsular cataract surgery.Lens epithelial cells remaining in the capsular bag after surgery play an important role in PCO.How to prevent and treat PCO is the focus of attention of eye scholars,and the major treating methods are administration of drug,laser and surgery.Recent years,scholars in home and abroad are interested in biological targeted therapy to prevent PCO,such as the topical application of antiproliferation of LECs,preparation of vector transfected immunotoxin and gene theropy etc.The research progress in recent years in the biological therapy of PCO were reviewed.