Objective To evaluate the curative effect and toxic reaction of pemetrexed combination with carboplatin as the therapy in advanced non-small cell lung cancer(NSCLC) of senium.Methods A total of 49 chemotherapy naive patients with ⅢB or Ⅳ NSCLC were enrolled in this study.Pemetrexed was given at a dose of 500mg/m2.Carboplatin dosed to an area under the time-concentration curve( AUC ) of 5.The chemotherapy was repeated every 21 days.Each patient was given at least 2 cycles.Results The curative effects of all the patients were evaluated.Among the 49 patients, the symptoms of 23 had been partially response ,21 stabilized and 5 progressed.The total effective rate was 46.9% ( 23/49 ).The efficiency of 68.2% in NSCLC with ⅢB phase were significantly higher than,29.6% in NSCLC with IV phase( X2 = 3.879, P < 0.05 ), Median time to progression (TIP) was 5.3 months.Median survival duration was 11.2 months( 3～ 21 months), and one year survival rate was 54.3%.The major toxicity included neutropenia, nausea, vomiting and diarrhea, impaired liver function, febrile neutropenia, etc.The severity of these side effect was in grade Ⅰ-Ⅱ and well tolerated.Among 49 cases,23 cases of leukopenia(46.9% ) was significantly higher than that of nausea in 11 cases (22.4%), vomiting in 5 cases ( 10.0% ), abnormal liver function in 4 cases( 8.0% ).Fever in 1 case ( 2.0% ) ( X2 = 3.879, P < 0.05 ; X2 = 8.451,8.778,9.123,9.741, all P < 0.01 ).Conclusion Pemetrexed combination with carboplatin was effective in the first line treatment of advanced non-small cell lung cancer,with mild to moderate side effect and safety in clinical practice.

0.05); in group C and D,there were still significant difference at 8 weeks. there were different histopatholog- ical changes in groups during the test. Conclusion:A mouse model of contusive spinal cord injury is a reasonable model and provides theory basis for SCI studies.

Objective To explore the effectiveness and safety of CT-guided chemical thoracic sympathectomy(CTS) for Raynaud′s phenomenon in the upper limbs.Methods Ten patients with Raynaud′s phenomenon in 20 limbs were enrolled in this study.Among the patients,4 were recurrent cases,who had undergone X-ray-guided CTS.Under CT guidance,a needle was punctured through the back skin to the second or third thoracic sympathetic ganglion beside the thoracic vertebrae,and then 3 ml of 5% phenol was injected into each located point.Results After the treatment,10 limbs achieved excellent outcomes,3 were good,4 were improved,and 3 were non-effective.The totally effective rate was 85.0%(17/20).The effective rate was 92.9%(13/14) in the limbs with primary Raynaud′s phenomenon,66.7%(4/6) in those with secondary Raynaud′s phenomenon,and 75.0%(6/8) for the recurrent cases.No patient developed pneumothorax. Conclusions CT-guided CTS is a minimally invasive surgery for Raynaud′s phenomenon in upper limbs with a high effective rate.The procedures can be used to treat recurrent cases.

OBJECTIVE:To investigate the compatible stability of ondansetron hydrochloride injection and carboplatin for injection.METHODS:The content of the mixture of ondansetron hydrochloride injection and carboplatin for injection was determined within8hours at a room termperature by ultraviolet-visible spectrophotography;its outward appearance was ob?served and the pH value of the mixture was determined.RESULTS:The appearance and pH value of the mixture had no distinct change.CONCLUSION:The mixture of ondansetron hydrochloride injection and carboplatin for injection was stable within8hours after interaction.

Objective:To provide anatomic basis for the location and protection of the tributaries of the inferior vena cava (IVC) in the retroperitoneal surgery.Methods:Fifty adult cadavers fixed with formalin were collected at random for study.The IVC and its tributaries were dissected,observed and measured in the region from the confluence of the left and right common iliac vein to the superior border of left renal vein(the initiative segment of IVC).Results:(1)The length of this segment of IVC was 13.12+1.51cm,and outer-diameter was 2.25?0.24cm.The number of vein tributaries from this segment was 8.75?2.02,66.3% of the tributaries entered the IVC posteriorly,and 66.4% of the tributaries entered the IVC on renal region(renal segment of IVC i.e.segment from the inferior end of right kidney to the superior border of left renal vein).(2)Vein tributaries:①Right gonad vein:84.9% of these veins entered the IVC anteriorly.The average distance from the point where the right gonad vein entering the anterior wall of IVC was approximately 3.56?0.85cm away from the superior border of left renal vein.②Lumbar vein(100%):The location of the lumbar veins in the infrarenal portion of the IVC was highly variable.A great number of veins was noted on the left(3～4)than on the right side(2～3). The veins tended to enter the IVC at different levels and not in pairs.③Surgical vein of mesentery(86%):The average distance from the point where the surgical vein entered the left side of anterior wall of IVC to the superior border of left renal vein was approximatately 6.94?1.21cm.④Right suprarenal vein(20%).⑤Right assistant renal vein (25%)⑥Right vein around kidney (36%).⑦Right inferior phrenic vein (6%).Conclusion:The result provides further morphological basis for retroperitoneal surgery.

Objective:To evaluate the novel technique of carotid-carotid bypass combines with windowed stent-graft in the treatment of aneurysms at the aortic arch without thoracotomy. Methods:Firstly,a right to left common carotid artery bypass was established with a graft with rings.Then the stent-graft was windowed at the determined position.Finally,the stent-graft was deploied into the aortic arch to exclude the aneurysm with the anonyma maintained patent.Results: The grafts were patent,and no brain ischemia or cranial accident occurred.The left upper limbs maintained there function.The left common carotid artery and the left subclavian artery were sealed.The aneurysms were occluded.Conclusions:The technique is a suitable method for the arch aneurysm,and is mini-invasive which may avoid of macro-trauma,large volume of blood loss, and the unstable of the blood dynaminc statement resulting from thoracotomy.The lumen of the aneurysm is still occluded thoroughly,and the procedure is simplified.But only a veteran endovascular doctor may control it safely.

Objectives: To evaluate the analgesic effect of electronic dental anesthesia(EDA).　Methods: Sixty patients with dental caries in need of cavity preparation and 15 patients with pulpitis in need of pulp treatment were anesthetized with EDA, another 60 patients with dental caries in need of cavity preparation and 15 patients with pulpitis in need of pulp treatment were anesthetized with traditional local anesthesia(LA).　 Results: For patients with dental caries in need of cavity preparation, the effective rates in EDA group and LA group were 93.33% and 98.33% respectively(P>0.05).For patients with pulpitis in need of pulp treatment ,the effective rates in EDA group and LA group were 26.7% and 93.33% respectively(P<0.01).　Conclusions: EDA can be an effective analgesic method for cavity preparation, but not for pulp treatment.

With the mature of techniques and development of equipments in excimer laser corneal refractive surgery,the postoperative complications are decreasing gradually.As the center of cornea become thin after laser in situ keratomileusis (LASIK)and laser subepithelial keratomileusis ( LASEK ),the strength of cornea and the intraocular pressure relatively step down,which can cause cornea anterior protrusion more or less.Because the posterior surface which is not directly affected by surgical process and healing process,so it is usually used to evaluate the protrusion of cornea.As the application of.ophthalmic anterior segment imaging and analysis system,we can get more message of cornea posterior surface.The manifestation,principle and precautionary measures of corneal posterior surface anterior protrusion after the excimer laser corneal refractive surgery were reviewed.

The 14th International Conference on Malignant Lymphoma (ICML) was held in Lugano, Switzerland from June 14, 2017 to June 17, 2017. More than 3500 lymphoma experts and scholars attended this unprecedented conference. In particular, the Joint Forum on Union for China Lymphoma Investigators (UCLI)-ICML jointly organised by UCLI and ICML had greatly improved Chinese academic status in the field of lymphoma worldwide. Chinese experience on the treatment of T-cell lymphoma was exchanged during the conference. This paper reviews the recent progress in treatment of T-cell lymphoma in the meeting.

Objective: To explore therapeutic effect of tolvaptan on chronic heart failure (CHF).Methods: A total of 102 CHF patients hospitalized in our hospital from Jun 2015 to Jun 2016 were selected.According to random number table, patients were divided into furosemide control group (n=52, received furosemide based on routine treatment) and tolvaptan group (n=50, received tolvaptan based on routine treatment).Cardiac output (CO), cardiac index (CI), stroke volume (SV), systemic vascular resistance (SVR) and therapeutic effect were observed and compared between two groups before and after treatment.Results: Compared with before treatment, there were significant rise in CO, CI and SV, and significant reduction in SVR in both groups after treatment, P<0.01 all;compared with furosemide control group after treatment, there were significant rise in CO [(4.41±0.71) L/min vs.(4.80±0.77) L/min], CI [(3.21±0.52) L·min-1·m-2 vs.(3.62±0.78) L·min-1·m-2] and SV [(70.09±14.90)ml vs.(79.60±13.10)ml], and significant reduction in SVR [(3111.30±931.85) dyne·s/cm5 vs.(2756.68±856.32) dyne·s/cm5] in tolvaptan group, P<0.05 or <0.01.Total effective rate of tolvaptan group was significantly higher than that of routine treatment (100.0% vs.75.0%), P=0.001.Conclusion: Tolvaptan can significantly improve heart function in patients with chronic heart failure,its therapeutic effect is significant, so it's worth extending.