Objective: The research was to investigate the intermediary effect of school adjustment between famale college students’ life meaning and mobile phone addiction and to provide reference for mobile phone addiction prevention. Methods: Totally 1 355 female college students in Jinan City were investigated with Life Meaning Scale, School Adjustment Scale and Mobile Phone Addiction Scale. Results: Score of freshmen’ mobile phone addiction (34.02±7.87) was significantly lower than that of sophomores’ and junior’(36.67±8.03, 37.19±10.40)(F=4.58, P<0.05). Female college students’ life meaning and school adjustment were negatively correlated with mobile phone addiction(r=-0.50, -0.58, P<0.01). Female college students’ life meaning was positively correlated with school adjustment(r=0.51, P<0.01). Having a sense of life meaning and seeking a sense of life meaning could jointly explain 24% of the variation in mobile phone addiction. School adjustment played a complete mediating role between life meaning and mobile phone addiction in female college students. Conclusion Female college students’ life meaning can affect mobile phone addiction through school adjustment.