Absent in melanoma 2 (AIM2) is a cytoplasmic protein, which can identify and combine with the cytoplasmic dsDNA to activate caspase-1, and promote the maturation and release of IL-1β and IL-18, or induce pyroptosis.AIM2 belongs to the innate immune system and is the first line of defense to protect the body against the invasion of alien microbes.After identifying the pathogenic microorganisms, the activation of the host signal caused the reaction, which started microorganisms.The activation of the host signal caused the reaction, which started the innate immune and acquired immune response.Research also suggests that AIM2 plays an important role in the occurrence and development of tumor, which was abnormally expressed in many malignant tumors such as prostatic cancer, colorectal cancer, breast cancer, nasopharyngeal carcinoma, oral squamous cell carcinoma, non small cell lung cancer, and AIM2 plays different roles in the progression of different tumor.This article will summarize the research progress of AIM2 in innate immunity and tumor development.

Objective:To investigate the method for treating facial post-burn hyperpigmentation. Methods: Forty-two patients with facial post-burn hyperpigmentation were randomly divided into two groups.Twenty-four subjects applied 15% Azelaic Acid cream combined with 0.025% Tretinoin cream daily to face,and eighteen subjects applied vehicle cream.At base line and six weeks of treatment,each subject's facial hyperpigmentation was assessed by area and colorimetric evaluations.Results:The facial post-burn hyperpigmentation of the Azelaic Acid and Tretinoin-treated subjects were significantly lighter after six weeks of therapy than those of the vehicle-treated subjects(?~(2)=10.94,P

Objective To clarify the frequency, the routes of transmission from mother to infant, the correlation factors and distribution of genotypes of transfusion transmitted virus (TTV) infection. Methods Nested polymerase chain reaction (n PCR) was performed to detect TTV DNA and genotypes in serums and breast milks from 160 cases of pregnant women. Results TTV DNA in serum and breast milk was detected in 64 (40 0%) and 60 (37 5%) of 160 cases of pregnant women respectively. The positive rates of TTV DNA from HBV markers (+) and normal groups were 50 0%, 43 1% and 13 6%, 22 7% respectively in serums and breast milk. There were significant difference between the two groups ( P

Objective:To compare the effects of a single dose of dexrazoxane or cAMP and their combined use on anthracycline cardiotoxicity in the multiple treatment course of patients with hematological malignancies to explore better alternatives for reducing an-thracycline cardiotoxicity. Methods: In the study, 80 patients were randomly divided into 4 groups with 20 cases each. Group A ( cAMP group) received cAMP 20 ml·d-1 for a week before every treatment course. Group B was treated with dexrazoxane and adria-mycin at a dosage ratio of 10∶1 via a fast intravenous drip 30 min before the application of anthracycline chemotherapy, and the 20 ml cAMP was given once a week before the chemotherapy session. Group C only received dexrazoxane. Anthracyclines was administered 30 min before each chemotherapy session. Groups A, B, and C were the experimental groups, and group D was designed as the blank control group. All groups received four complete cycles of chemotherapy. The ECG changes, echocardiography ( left ventricular ejection fraction, LVEF) and B-type brain natriuretic peptide ( BNP) values of all the groups were observed before and after the chemotherapy. Results:As for the ECG changes, group B and C had lower incidence rate of abnormal ECG than group A and D(P<0. 008 3). Sig-nificantly decreased LVEF and increased BNP values were observed in group A, B and C compared with those in the control group ( P<0. 05), and group B showed the most significant effect. Conclusion:All of the studied treatments can effectively reduce anthracy-cline chemotherapy-induced cardiotoxicity in cancer patients, and the combination of cAMP and dexrazoxane exhibits the best effect. Dexrazoxane has better protective effect on myocardial cells than cAMP.

Objective To explore the relationship between the ST-T continuous changes of ECG and the chronic coronary insufficiency.Methods 158 cases of ST-T continuous changes of ECG were treated with selective plate exercise tests and the coronary arteriography.Results 54 cases of plate exercise tests were positive(34.2%),104 cases were negative(65.8%).36 cases were diagnosed as the stenosis of coronary through the coronary arteriography(22.7%).But among 54 positive cases of plate exercise tests,33 cases had the stenosis of coronary,accounting for 91.6% in the cases of stenosis of coronary.Conclusion The quiescent ECG ST-T continuous changes aren't specfic changes of chronic myocardial ischemia.Most of them are caused by other reasons.

Objective To investigate the whole differentiating process of myogenic satellite cells in vitro,and the expression of N-ACh receptors.Methods Skeletal muscle satellite cells were isolated by trypsin digestion in vitro and purified by preferential attachment method.The cells were observed morphologically and identified by ?-sarcomeric actin,desmin and skeletal myosin antibodies.Contraction of myotubes was observed after adding ACh in the culture medium, N-AChRs in myotube were also be identified by bungarotoxin.Results Cultured satellite cells in vitro differentiated into myoblasts and fused to form myotubes later.These cells were positive by ?-sarcomeric actin, skeletal myosin and desmin antibodies' staining.Adding ACh directly in the medium stimulated the contraction of myotubes.No obvious expression of ACh receptors was observed on the surface of satellite cells.Cluster of receptors aggregated on myotubes from neonatal rats' satellite cells cultured in differentiation media.Conclusion The myotubes differentiated from myogenic satellite cells have the function of contraction.N-ACh receptors were synthesized gradually during the process of differentiation.

The distributions of estrogen receptors in preoptic region of hypothalamus, anterior lobe of pituitary gland, mammary gland, thymus and liver of LACA and C57 BL strains of mice were studied by ~3H-estradiol and autoradiography in frozen sections.In both strains of mice, labelling index (LI) was more than 85％ in preoptic region of hypothalamus and anterior lobe of pituitary gland, and average number of silver grains (AG) was more than 19. LI and AG of epithelial cells of mammary glands in LACA strain of mice were quite high, 96％ and 12 respectively; but in C57BL strain of mice were only 5％ and 5 respectively. A few hepatic cells and lymphocytes of thymus were labelled.According to the above results the reason of why mammary carcinoma of female LACA strain of mice and adenoma of pituitary gland of C57BL strain of mice could 15e easily induced by estrogenic hormones (estradiol valerate and hydroxyprogesterone caproate, EP), but no mammary carcinoma was induced in C57BL strain of mice by EP, and this can be partly explained by the presence of a large or few number of estrogen receptors. However, the presence of estrogen receptors was only a prerequisite but not a unique condition. Other factors should be considered, because many more estrogen receptors were present in preoptic region of hypothalamus of both strains of mice and anterior lobe of pituitary gland of LACA strain of mice, but few or no tumors could be induced by EP.

The post-operative adjuvant chemotherapy(PAC) for non-small cell lung cancer(NSCLC) appeared on the 1970s of the 20th century. Along with the appearance of each kind of new drugs and new combined therapeutic regimen, PAC for NSCLC is also progressed gradually, and more and more evidence showed that PAC can improve the survival and quality of life of patients with NSCLC. The present situation of PAC for NSCLC and the prospects of its future development were introduced.

Dental Implantation ; methods ; Humans ; Jaw ; physiology ; surgery ; Reconstructive Surgical Procedures ; methods

Accidents, Occupational ; prevention & control ; Causality ; Humans ; Occupational Diseases ; etiology ; prevention & control ; Risk Assessment