2.Clinical Observations of the Analgesic Effect of Epidural Resiting Following Accidental Dural Puncture
Journal of Chinese Physician 2002;0(S1):-
Objective To evaluate the safety of epidural resiting and the incidence of postdural puncture headache following accidental dural puncture. HZ Methods Among 63 patients of ASA I-II undergoing lower abdominal or lower extremity surgery, forty-two with postdural puncture who had received epidural resiting were randomly assigned to patient controlled epidural analgesia (PCEA) ( n =21) or control treatment ( n =21). The remaining 21 patients who had successful epidural insertion received the routine PCEA. All patients after operation received 48-hours monitoring of BP, HR, RR and SpO_2. The analgesic effect of each treatment and the occurrence of headache were also assessed. Results All operations were uneventful under epidural anesthesia. A satisfactory level of analgesia was observed in patients who received PCEA. There was no statistically significant difference in pain control between patients who had had epidural resiting and who received PCEA and those who received routine PCEA. No respiratory inhibition was observed. The occurrence of headache in the epidural resiting group was 19% (4/21), compared to 57% (12/21) in the control group ( P
3.Screening of Auramine O in Guci Tablets by HPLC
China Pharmacist 2015;(1):172-173
Objective:To screen auramine O in Guci tablets. Methods:Auramine O was detected by HPLC method on a Diamon-sil-C18(250mm×4.6mm,5μm)columnwiththemobilephaseofacetonitrile-0.025mol·L-1monopotassiumphosphatebuffersolu-tion(containing 0. 2% triethylamine,adjusting pH to 3. 0 with phosphoric acid)(36∶65)at the flow rate of 0. 8 ml·min-1. The detec-tion wavelength was 432 nm and the column temperature was 35℃. Results:The LOD of auramine O was 0. 05ng. Among 45 batches of tested samples, auramine O was found in seven ones. Conclusion:The method is simple, rapid and accurate, which can guarantee the drug safety of Guci tablets.
4.Clinical observation on the treatment of distal radius fractures operation
Chinese Journal of Postgraduates of Medicine 2014;37(17):18-20
Objective To investigate the therapeutic effect of distal radius fractures operation.Methods Eighty distal radius fractures patients who were treated from January 2010 to January 2011 were divided into observation group and control group by random digits table method,each group had 40 cases.The observation group was treated with plate internal fixation,the control group took closed reduction and splint external fixation.The palmar tilt,radial ulnar deviation,axial shortening before treatment and after treatment for 3 months were compared between two groups.The clinical curative effect after treatment for 1 year was compared.Results The palmar tilt,radial ulnar deviation,axial shortening before treatment between two groups had no significant difference (P > 0.05).After treatment for 3 months,the palmar tilt,radial ulnar deviation,axial shortening in observation group were (17.0 ± 1.6)°,(23.0 ± 2.1)°,(1.0 ± 0.2) mm,in control group were (4.0 ± 0.8)°,(10.0 ± 1.1)°,(4.0 ± 1.1) mm,there was significant difference(P< 0.05).After treatment for 1 year,the excellent and good rate in observation group was 90.0%(36/40),significantly higher than that in control group [50.0% (20/40)] (P < 0.05).Conclusion Plate internal fixation in the treatment of distal radius fractures is more conductive to the wrist recovery of joint structure and function,reduce the occurrence of wrist joint dysfunction,improve the quality of life,and is worth to be applied in clinic.
5.Diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer
Journal of Chongqing Medical University 2003;0(06):-
Objective:To explore the diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer.Methods:Using pathological examination,or at least one-year clinical follow-up results for the gold standard,we divided patients with liver disease into three two groups:primary liver cancer group,benign liver disease group and normal group,using protein chip technology to detect the measurement serum tumor markers.Results:CA199,CEA,CA242,FER,AFP,CAl25 and CA153 were significantly higher in PHC group than those in benign liver disease group and normal group(P
6.Determination of Related Substances in Pantoprazol Sodium Enteric-coated Capsules by HPLC with Gradi-ent Elution
China Pharmacist 2015;(6):943-945
Objective: To establish a method for the determination of the related substances in pantoprazole sodium capsules. Methods:A Kromasil C18 column (250 mm × 4. 6 mm, 5 μm) was used. 0. 01 mol·L-1 monopotassium phosphate solution (adjus-ting pH to 7. 0 with phosphoric acid)-acetonitrile was adopted as the mobile phase with gradient elution. The detection wavelength was 289 nm and the column temperature was 40℃. The injection volume was 20μl and the flow rate was 1. 0 ml·min-1 . Results:Panto-prazole sodium and its degradation substances could be well separated. The limit of detection and quantification of pantoprazole sodium was 0. 16 ng and 0. 48 ng, respectively. Conclusion:The method is simple, specific and sensitive, and can be applied to determine the related substances in pantoprazole sodium.
7.Progress on pre-exposure prophylaxis (PrEP) for HIV infection
Chinese Journal of Clinical Infectious Diseases 2014;7(1):81-84
Anti-retroviral (ARV) drugs have been successfully used for HIV/AIDS therapy,and their uses in pre-exposure prophylaxis (PrEP) for HIV infection is becoming increasingly important,and is drawing more attentions.Reports on seven large scale,multicentric clinical trials provide significant clinical data for further study and implementation of PrEP.This article reviews the current situation,necessity,questions,problems and prospects of PrEP for HIV infection.
8.The research on clinical teachers' behavior choices in the aspects of medical care, education and research
Chinese Journal of Medical Education Research 2012;11(2):147-151
Objective The aim of this study is to discuss the clinical teachers' behavior choices in the aspects of medical care,education and research,and explore the related factors by making an investigation.Methods This study adopts the method of Literature Review,interview and questionnaire investigation.Results 57.6% of clinical teachers obviously felt enormous pressure,83.28% of clinical teachers support the saying busy and time pressing is one of the most important facts; in view of the time allocation,the majority of the clinical teachers' arrangement is medical care > research > education or medical care > education > research.Conclusions Time and energy became the scarce resources for clinical teachers.On the other hand,the conflict relationship among medical care,education and research makes clinical teachers stand at the crossroads.The understanding of the relationship among medical care,education and research,and the policy environment are important factors when a clinical teacher was making a stand.
9.The effect analysis of omeprazole or famotidine combined with itopride in the treatment of reflux esophagitis
Chinese Journal of Primary Medicine and Pharmacy 2012;19(17):2569-2570
Objective To observe the effect of omeprazole or famotidine combined with itopride in the treatment of reflux esophagitis.Methods 86 patients with reflux esophagitis were randomly divided into two groups,which group A with 43 eases was treated with omeprazole combined with itopride,and group B with 43 cases was treated with famotidine combined with itopride.The clinical effect and main symptoms were observed and compared.Results The total effective rate in group A was 91.3%,significantly higher than that of group B ( 71.4% ) ( x2 =5.460,P <0.05 ).After treatment,the scores of heartburn,acid reflux and chest pain were significantly decreased ( all P < 0.05 )in both two groups.Moreover,the scores of heartburn,acid reflux and chest pain in group A after treatment were significantly lower than those of group B ( all P < 0.05 ).Conclusion Omeprazole combined with itopride in the treatment of reflux esophagitis is better than famotidine combined with itopride.
10.Salient cues enhance strategy monitoring and task switching for prospective memory:An ERP study
Chinese Journal of Behavioral Medicine and Brain Science 2009;18(6):526-528
Objective To investigate the retrieval mechanism of prospective memory,spatiotemporal patterns of event-related potentials (ERP) were used to reveal neural correlates of the prospective interference effect. Methods A task of matching two sequential patterns was taken as the ongoing task and the detection of patterns with two salient levels as prospective memory tasks. Experiments were performed in blocks for single ongoing task block and two prospective memory blocks. Results No significant behavioral effect was found for prospective interference [reaction time(ms):control blocks 750.29±161.33,high salience blocks 770.94±174.89,low salience bocks 764.79±174.12,F(1.52,25.82)=0.48,P =0.57 and correction rate(%):control blocks 85.89±8.07,high salience blocks 88.26±7.00,low salience blocks 87.91±7.28,F(1.50,25.57)=2.46,P =0.12].But significant ERP effect was found at bilateral frontal regions from 160 ms to 240 ms for both two prospective memory blocks. Moreover,greater negativity at the right frontal polar region appeared significantly at 360'440 ms for higher salient patterns. Conclusion Prospective memory is retrieved based on strategic monitoring and high salient stimuli may enhance to keep the prospective goal and improve task switching.