Objective To investigate the effect of acupoint massage on vital signs in patients undergoing percutaneous coronary intervention surgery.Methods128 patients underwent percutaneous coronary intervention surgery from January 2014 to June 2016 were divided into the observation group and the control group according to the random number table, 64 cases in each group.The control group were given traditional surgery,and received routine treatment at postoperative rehabilitation period.At the basis of this, the observation group were given acupoint massage.The liver and kidney function indexes, coagulation function, blood routine, heart rate and blood pressure in the two groups were compared.ResultsThe systolic blood pressure was (142.98±18.35mmHg, the diastolic blood pressure was (92.83±17.28) mmHg and the heart rate was (79.4±11.7) times/min in the observation group;the systolic blood pressure was (143.26±17.26) mmHg, the diastolic blood pressure was (82.65 ± 13.17) mmHg and the heart rate was (71.9±12.1) times/min in the control group, the differences in the two groups was statistically significant(P<0.05).The TBIL of the control group was (9.36±3.71)umol·L-1, DBIL was (4.01±1.14)umol·L-1, TP was (53.23±7.29) g·L-1, and the difference was statistically significant (P<0.05, ALB was (32.10±3.17) g·L-1 and BUN was (4.23 ± 1.32) mmol·L-1, which was lower than that of TBIL, DBIL, TP and ALB in the observation group (P<0.05) The levels of PTA and FIB in the observation group were higher than those in the control group.The levels of PT, APTT and TT were lower than those in the control group, the difference was statistically significant (P<0.05).ConclusionAcupoint massage can effectively enhance the liver and kidney function and coagulation function, reduce the blood pressure and heart rate of patients, relieve anxiety and reduce the recovery time of patients.

Objective To analyze effectiveness evaluation of Salbutamol combined with budesonide suspension on acute attack of bronchial asthma.Methods150 patients with acute attack of bronchial asthma in hospital from October 2015 to October 2016 were selected,patients were divided into observation group and control group,every groups with 75 cases.Control group patients were given inhalation of salbutamol,observation group patients were given salbutamol combined with budesonide treatment,two groups patients effect were analyzed.ResultsThe total effective rate of the observation group (90.7%) was significantly higher than that in control group (65.4%) (P<0.05).There was no significant difference between the two groups before treatment.The observation group was significantly better than the control group (P<0.05),cough and wheeze improvement time was significantly shorter than the control group (P<0.05).The observation group average dosage of prednisone was significantly lower than the control group (P<0.05).ConclusionWith the implementation of salbutamol combined with budesonide suspension treatment can improve the effect of the treatment of acute attack of bronchial asthma.

The evolutionarily conserved Notch family widely exists in vertebrates and invertebrates and plays crucial roles in several biological processes such as embryogenesis, cell proliferation, apoptosis, as well as the differentiation and function of immune cell.Being different from Th1 and Th2 cell subsets, Th17 cells are new subset of CD4+ T cells and can secrete many kinds of cytokines, such as IL-17, IL-17F, IL-21 and IL-22.Recently, Th17 cells are considered to play important roles in asthma, rheumatic arthritis, systemic lupus erythematosus and malignant tumor.This review focuses on the research progress of Notch signaling pathway and its regulatory roles on Th17 cells.

Objective To investigate the clinical effect of Salvia Ligustrazine Injection in the treatment of hypertensive intracerebral hemorrhage.MethodsFrom February 2013 to May 2016, 118 patients with hypertensive intracerebral hemorrhage admitted in our hospital were randomly divided into Danshen ligustrazine group, conventional group and 59 cases.2 groups of patients were treated with the same basic treatment after surgery, Salvia Ligustrazine group also received Danshen ligustrazine injection, compared the two groups after treatment of clinical effects, nerve defect function recovery.ResultsAfter 14 days of treatment, the Glasgow Coma Scale (GCS) GCS score, neurological deficit score, C reactive protein (CRP) and ET-endothelin-1 were lower in the Salvia Ligustrazine group (13.56%), brain edema in grade 1 (83.05%), 2 cases of brain edema in grade 2 (3.39%), and 9 cases of cerebral edema in grade 2 (79.66%), 9 cases (15.25%) in grade 2 brain edema, the difference was statistically significant (P<0.05), and the treatment group was significantly higher than that in the control group After 3 months, the prognosis of patients with Salvia miltiorrhiza was good (49.05%), and the prognosis was good in 39 cases (66.10%), the difference was statistically significant (P<0.05).ConclusionSalvia Ligustrazine Injection is an effective method for the treatment of hypertensive intracerebral hemorrhage in patients with cerebral edema as soon as possible.It can promote the recovery of neurological function and benefit the patients' long-term recovery.

Objective: To explore therapeutic effect of individualized cognitive training on improving cognitive function in aged patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).Methods: A total of 92 aged CHD patients after PCI, who were diagnosed and treated in our hospital, were selected.According to random number table, they were randomly and equally divided into routine nursing group (n=46) and cognitive training group (n=46, received active individualized cognitive training based on routine nursing), both groups were observed for three months.Scores of Montreal cognitive assessment (MoCA), self-rating anxiety scale (SAS) and self-rating depression scale (SDS), and left ventricular ejection fraction (LVEF) were compared between two groups before and after nursing.Results: Compared with before nursing, after nursing, there were significant rise in LVEF and MoCA score, and significant reductions in scores of SAS and SDS in both groups (P<0.01);compared with routine nursing group, there were significant rise in LVEF [(51.87±4.89)% vs.(58.29±5.13)%] and MoCA score [(24.44±4.10) scores vs.(29.34±3.14) scores], and significant reductions in scores of SAS [(38.22±5.64) scores vs.(32.09±4.11) scores] and SDS [(37.22±4.98) scores vs.(30.56±5.68) scores] in cognitive training group, P<0.01.Training compliance of cognitive training group was significantly higher than that of routine nursing group (95.7% vs.82.6%, P=0.044).Conclusion: Individualized cognitive training can significantly improve training compliance after PCI, significantly improve cognitive function, relieve anxiety and depression, and enhance cardiac function in aged CHD patients.

With the development of nanotechnology,nanomaterials have great application potential in drug delivery system.Understanding the cellular uptake mechanism of nanoparticles has important scientific significance and application value in understanding life processes in cellular level,mechanisms of drug action and gene therapy,which provides the basis for developing safer and more effective nanosized drug carrier.This review summarizes the latest advancement about cellular uptake mechanisms of nanopatricles.Based on a brief introduction of the endocytic pathway of nanoparticles,influencing factors of endocytosis pathway are discussed,and the common methods used to study nanoparticle endocytosis pathways are also introduced in detail.

Objective To study the effect of chitosan/tricalcium phosphate(CTCP)on the attachment and proliferation of bone marrow stromal cells(BMSCs)cultivated in vitro and explore their biocompatibilities.Methods The CTCP was prepared by freeze-drying.BMSCs were cultivated in vitro,collected and seeded onto the surface of CTCP.Cell attachment and proliferation were obesrved using inverted light microscope and scanning electron microscopy(SEM).The cell proliferation was tracked by MTT method 2,4,6,8 d after seeding.Results BMSCs were fibroblast-like 2 d after seeding.The mean number of cells was(360?20) and(76?18),respectively,in the experimental and control group per 100 eyesight field,the difference was significant(P

Objective To investigate proper indications of endoscopic sphincterotomy (EST). Methods A retrospective review was made on 9 cases of EST with controversial indications from January 2005 to January 2006 in this hospital. There were 1 case of jaundice due to hepatitis and intrahepatic cholestasis, 1 case of intrahepatic and extrahepatic cholelithiasis, 1 case of common bile duct stones, 2 cases of bile duct obstruction due to malignant tumors at upper (1 case) or lower segment (1 case), 2 cases of papillary tumors, 1 case of choledochal cyst, and 1 case of gallstones accompanying common bile duct stones. Results Except for 1 case of jaundice due to hepatitis and intrahepatic cholestasis misdiagnoed as having obstructive jaundice, surgical indications presented in 8 cases. Of the 8 cases, 5 cases were given a surgical operation following EST, 1 case was inoperable because of worse general condition after EST, and a radical operation was given up in 2 cases of end-stage tumors. Conclusions Without complete relief of proximal bile duct obstruction, EST may worsen the patient’s condition instead of curing the biliary diseases. EST may be unnecessary for resectable tumors, especially in young patients.

The Apolipoprotein E(APOE)gene plays important roles in the pathogenesis of the Alzheimer disease(AD).It is clear that APOE gene is closely related with dementia in the elderly.In recent years,extensive researches regarding the relationship between APOE gene polymorphism and AD has been conducted in both health population and patients with AD using molecular biology technique.This paper reviewed the progress in this field for sharing some fundamental information on the research in AD.

BACKGROUND:Cyclosporine A has shown its immunosuppressive effects and has been widely used in clinical organ transplantation.OBJECTIVE:To review the recent studies on the immunosuppressive mechanisms and the active pathway of cyclosporine A.RETRIEVAL STRATEGY:A compute-based online search of ScienceDirect Onsite,ProQuest,Springer and Ovid,based on the data from Peking University Medical Library,was undertaken for the English articles concerning with the immunosuppressive mechanism of cyclosporine A from January 1990 to December 2006,with the keywords of "cyclosporine A,mechanism/action,immunosuppression".Totally 68 articles were collected after the first trial,and the preliminary screening was conducted for the titles and abstracts.Inclusion criteria:articles related with the immunosuppressive mechanisms of cyclosporine A.Repetitive studies were excluded.Fifty accorded with the inclusive criteria,and 46 of them regarding tracheal transplantation were selected for the full-texts as the references.LITERATURE EVALUATION:Forty-six included articles included 6 ones about the clinical use and effects of cyclosporine A,and 40 involving the related studies on the molecular mechanisms of cyclosporine A.DATA SYNTHESIS:The review of literatures indicates that,the immunosuppressive mechanisms of cyclosporine A consist of:① the calcineurin/nuclear factor of activated T-cells pathway,②the activation of JNK and P38 signaling pathways,③other effects.CONCLUSION:Cyclosporine A selectively regulates the function of peripheral blood lymphocytes subgroup,blocks the activation of cytotoxic T-cells,and possibly inhibits the formation or reaction of memory T-cells.But it doesn't affect activation and proliferation of suppressive T-cells,or expression of interleukin-2 receptors,which may induce selective immunosuppression.