Animals ; Humans ; Reproducibility of Results ; Selenium ; analysis ; Spectrometry, Fluorescence ; Spectrophotometry, Atomic

Objective To investigate the effect of metabolic parameters on the self-efficacy in patients with diabetes mellitus.Methods 175 diabetes mellitus patients were recruited by random sampling method.Demographic data and metabolic parameters were obtained and the scales of self-efficacy of diabetes patients were evaluated by secd6.We further analyzed the effect of metabolic parameters on the selfeffficacy in diabetes mellitus patients.Results Two-hour postprandial blood glucose had negative correlation with self-efficacy among 10 metabolic parameters in diabetes mellitus patients.Conclusions Twohour post-prandial hyperglycemia affects the scale of self-effcacy.So we should strengthen the management of two-hour postprandial hyperglycemia to increase the self-efficacy in diabetes mellitus patients.

Hepatic resection has been the main form of the treatment of liver benign and malignant tumors. With the popularity of applications of minimally invasive techniques in surgery in recent years, laparoscopic hepatectomy(LH) application has also achieved a rapid development. It' s advantages are known as a small open incision, light systemic response and rapid recovery, meanwhile it can also attain the same efficiency as the open surgery does. However, there also exist disadvantages, such as complicated conduct, expensive instruments, and bleeding problems. This article reviews the process of development of laparoscopic liver resection, and elaborates its current status, existing problems, and evaluation of its treatment and efficiency.

Objective To explore the impact of season and latitude on multiple sclerosis by study the onset/relapse season and latitude distribution in multiple sclerosis (MS) patients.Methods A total of 264 MS patients , with 88 males and 176 females, who were hospitalized in Beijing Tiantan Hospital from January 2002 to December 2012, were enrolled in the study and all the clinical data were retrospectively analyzed.The mean age was (33.9 ± 12.3) years old, with the disease duration of (6.3 ±4.5) years and 453 cases of relapse.The recurrence of MS was collected by four seasons, with March to May defined as spring, June to August as summer, September to November as autumn and December to February as winter.MS patients lived in Beijing (39.39° N-41.07° N) were chosen to test the correlation between the incidence/recurrence and monthly mean temperature, sunlight exposure intensity and duration.All the patients were divided into the high latitude group and the low latitude group, taken the latitude median (40.22° N) of Beijing area as the boundary.Gender composition, age of onset, disease duration and recurrence rate were compared between the two groups.Results Most of the onset/ relapse of MS were observed in winter (134 cases), while summer (97 cases) took the least.In the same latitude region (Beijing area), the onset/ relapse of MS was negatively correlated to the mean temperature and sunlight exposure intensity (r =-0.699, P =0.006;r =-0.623, P =0.015).Recurrence was higher in the high latitude group than in the low latitude group [68.7％ (123/179) vs 63.0％ (51/81), P =0.000], while no significant difference was found in gender composition, age of onset and disease duration between the two groups.Conclusion The onset/recurrence of MS has obvious seasonal characteristics.The onset/recurrence of MS is correlated with latitude, temperature and sunlight exposure intensity of the habitation of MS patients.Environmental factors are important cause of the onset/recurrence of MS, with sunshine exposure as the most key factor.

Objective To compare the efficacies of automatic erythrocyte sedimentation rate (ESR) analyzer using EDTA as blood anticoagulant ,traditional Westergren method and ESR analyzer using sodium citrate as blood anticoagulant in detecting ESR , in order to chose the appropriate one for clinical application .Methods A total of 40 samples were collected and divided into 3 groups .The ESR was detected by using XC‐A30 automatic ESR analyzer using EDTA as blood anticoagulant (XC ESR analyzer) , Westergren method and VISION‐C automatic ESR analyzer using sodium citrate as blood anticoagulant (VISION ESR analyzer) ,re‐spectively .Statistical analysis was used to comparing the detection results of ESR among the three methods .The repeatability test was carried out for evaluating repeatability of VISION ESR analyser .Results There was statistically significant difference in ESR detected by using Westergren ,XC ESR analyzer and VISION ESR analyzer(F=86 .497 ,P=0 .000) .There was statistically signifi‐cant difference in ESR between that detected by using XC ESR analyzer and that detected by using Westergren (t= -4 .08 ,P=0 .004) .The ESR detected by using VISION ESR analyzer was positively correlated with that detected by using Westergren (r=0 .975 ,P=0 .000) .There was no statistically significant difference in ESR between that detected by using VISION ESR analyzer and that detected by using Westergren(t=0 .65 ,P=0 .638) .The repetitive tests of analyzer shown that the within‐run coefficient of variation(CV) and between‐run CV both were less than 10% .Conclusion The ESR detected by using VISION ESR analyzer which is simple operation and with credible result has good correlation with that detected by using Westergren .The VISION ESR analyzer might be suitable for clinical application .

Objective To observe the intervention effect of different compatibility of aconite and peony in Zhenwu Decoction on experimental nephritis in rats, and explore the connotation of suitable fire and evil fire. Methods Sixty experimental rats were randomly divided into blank group, model group, valsartan group, high aconite and low peony group, aconite and peony equivalent group, low aconite and high peony group. All rats except the blank group were made glomerulonephritis model by tail vein injection of monoclonal antibody 1-22-3. Rats were gived continuous gavage administration (blank group and model group were lavaged with NS) after modeling, and killed 2 weeks later. The morphological change of kidney tissues and serum hs-CRP, TNF-α, IL-6 levels were observed. Results The valsartan group, aconite and peony equivalent group, low aconite and high peony group inhibited the rats mesangial cell proliferation and extracellular matrix expansion significantly, so as the level of hs-CRP, TNF-αand IL-6. The effect of aconite and peony equivalent group was better than low aconite and high peony group, but inferior to valsartan group, while high aconite and low peony group accelerated the progress of the disease. Conclusion The different compatibility of aconite and peony in Zhenwu Decoction has resistance and proinflammatory effect on renal inflammation.

Colorectal cancer is easily metastasized to the liver.Surgical treatment is the best choice for the treatment of colorectal cancer,while the treatment strategy should be selected according to different stages of colorectal liver metastases.Liver metastases occurred at the definite diagnosis of colorectal cancer or within 6 months after radical resection of colorectal cancer are synchronous liver metastases,the timing of synchronous liver metastases resection is still under controversy.Liver metastases occurred at 6 months after radical resection are metachronous liver metastases,and for patients with metachronous liver metastases,reoperation should be applied if the indications are clear.Chemotherapy,radiofrequency ablation and interventional therapy provide chances of reoperation for patients who originally cannot received surgical treatment,while confusion exists in their clinical application.Therefore,multi-disciplinary treatment based on individualized condition evaluation is the key point in improving the prognosis of patients with colorectal liver metastases in different stages.

Objective To establish the scientific, rational and standard librarian performance appraisal index system in academic library in order to adjust their working behaviors, improve their service quality and increase the overall performance of library.Methods The current librarian performance appraisal situation was investigated according to the literature and on the field inspection.The appraisal indexes and their weight were established by Delphi and step analysis.Results The 3-scale appraisal index system was established, which include 4 No.1 indexes, 10 No. 2 indexes, and 59 No.3 indexes with their weight and score displayed.Conclusion The performance appraisal index system we established can effectively arouse the enthusiasm of librarians in scientific research innovation, manage-ment or social work.

Purpose To study the morphological features, immunohistochemical phenotype, diagnosis and differential diagnosis of hep-atoblastoma in children. Methods The pathologic data of 58 child patients with hepatoblastoma were enrolled in this study, and histo-logical classification with distinct clinical associations were used. Prognostic data were also collected. Results Pure epithelial type was 33 cases, pure fetal type 18 cases, including 8 cases of low mitotic activity type, 9 cases of high mitotic activity, and 1 case of fo-cal pleomorphic type. 11 cases were embryonal type, 3 small undifferentiated type and 1 transitional liver cell tumor. All the 25 cases of mixed epithelial and mesenchymal type were without teratoid features, including fetal epithelial and mesenchymal type (6 cases), embryonal epithelial and mesenchymal type (17 cases), transitional liver cell tumor and mesenchymal type (2 cases). Follow-up data were available in 14 cases, in which 12 cases were sensitive to chemotherapy. Conclusions Pathologic type of hepatoblastoma rely mainly on the histology, which has a certain clinical prognostic significance. The stage of the tumor and the histopathologic type are two key prognostic factors in determining the survival of children with hepatoblastoma.

The study aims to identify related substances in orlistat pharmaceutical substance from different production technologies. Advanced technologies including UPLC-QTOF-MS and UPLC-QTrap-MS were used and the structures or molecules of 10 kinds of related substances in orlistat were identified. The experimental data were valuable to the quality control and development of orlistat.