With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

Acquired Immunodeficiency Syndrome ; prevention & control ; China ; Humans ; Infectious Disease Medicine ; methods ; trends

HIV/AIDS has been circulating in China for over 25 year. While making progress and achievements on HIV/AIDS prevention, there still are great challenge and difficulties such as HIV epidemic controlling and vaccine research.

Objective To compare the effect of laparoscope and open operation in the treatment of acute perforation of peptic ulcer.Methods Clinical data of 56 peptic ulcer patients were retrospectively analyzed.30 patients (group A) received laparoscopic treatment,26 cases(group B) received traditional open operation treatment.Operation time,hospitalization time,postoperative exhaust time,ambulation time,frequency of using analgesics after operation,incidence rate of complications and the cost of hospitalization were compared between the two groups.Results In A group,the hospitalization time was (4.5 ± 1.4) d,postoperative exhaust time was (23.9 ± 7.2) h,time to ambulation was (14.1 ± 5.6)h,frequency of postoperative analgesic use was 16.7％,the incidence rate of complications was 0,which were better than those in the control group(11.6 ± 7.5) d,(37.6 ± 17.9) h,(43.4 ± 11.8) h,92.3％,19.2％ (t =4.23,4.54,6.32,x2 =3.78,4.45,all P ＜ 0.05).Operation time,white blood cell count and cost of hospitalization between two groups showed no significant differences(P ＞ 0.05).Conclusion Laparoscope in treatment of acute perforation of peptic ulcer has advantages of less trauma,less complications,quicker recovery,shorter hospitalization time and good clinical effect.This operation mode is relatively ideal,and is worth the clinical promotion.

Objective To investigate the effect of the high school students' authenticity in the relationships with parents and friends on their behavior problems and loneliness.Methods A total of 619 high school students in Guangdong province participated in this study.The instruments included the Authenticity Scale,the Youth Self-Report and the State versus Trait Loneliness Scales.Results (1) Authentic self in the relationship with parents were significantly and negatively related to internalizing problems (depression/anxiety,social withdrawal and somatic complaints,standardized regression coefficients were-0.17,P ＜ 0.01 ;-0.10,P ＜ 0.05 ;-0.10,P ＜ 0.05),externalizing problems (aggression and delinquency,standardized regression coefficients were -0.16,P ＜ 0.01 ;-0.21,P ＜ 0.01) and loneliness (trait loneliness and state loneliness,standardized regression coefficients were-0.17,P ＜0.01 ;-0.17,P ＜0.01).(2) Authentic self in the relationship with friends was significantly and negatively related to internalizing problems (depression/anxiety,social withdrawal and somatic complaints,standardized regression coefficients were-0.24,P＜ 0.01 ;-0.28,P＜ 0.01 ;-0.10,P＜ 0.05) and loneliness(trait loneliness and state loneliness,standardized regression coefficients were-0.29,P ＜ 0.01;-0.34,P ＜0.01).Conclusion Authenticity in the relationships with parents and friends has the positive effect on adolescents' psychosocial adjustment.

Objective To study the current application and influencing factor of emergency medical service in patients with acute heart failure in our hospital.Methods 254 patients with acute heart failure who visited our hospital from January 2008 to December 2010 were selected.Data were collected by questionnaire and medical records in one week after admission to the hospital.The current application and influencing factors of emergency medical service in patients were analyzed.Results Of all the patients with acute heart failme,only 89(35％)arrived at the hospital by emergency medical service,but the rest 165(65％)relied on self-transport.Multivariate logistic analysis showed that age,sex,education level,unbearable symptoms and attribution of symptoms to cardiac origin were independent predictors of the use of emergency medical service.The effective treatment rate was higher,and the pre-hospital time was shorter in patients who used emergency medical service than those relied on self-transport.Conclusions The use rate of emergency medical service in patients with acute heart failure is low,and age,sex,education level,the characters of symptoms and cognitive factors of patients influence the use of emergency medical service in patients with acute heart failure.

Objective To investigate the application effect of intensified nursing intervention in severe pneumonia complicated with ventilator-associated pneumonia. Methods 78 senile patients admitted to hospital with severe pneumonia complicated with ventilator-associated pneumonia from November 2009 to November 2010 were chosen as the research object.They were randomly divided into the observation group and the control group with 39 cases in each group.The control group was treated with conventional and comprehensive methods of care.The observation group was taken intensified intervention on the basis of the control group.The utility time of ventilator after complication with ventilator-associated pneumonia,hospital stay time,complications and mortality rate for the two groups were compared. Results The utility time of ventilator,hospital stay time,complications and mortality rate for the two groups were compared.The observation group had a clear advantage over the control group,there was significant difference. Conclusions Nursing intervention can be targeted to enhance the improvement of the overall respiratory status in severe pneumonia complicated with ventilator-associated pneumonia.It contributes to inflammation control,and can reduce utility time of ventilator and length of hospital stay,reduce the corresponding incidence of complications and mortality rate,it is worthy of clinical application.

Objective To investigate the curative effect of western combined with traditional Chinese medicine in treatment of acute lumbar disc herniation.Methods 200 patients with lumbar disc herniation were randomly divided into western combined with traditional Chinese therapy group(group A) and western medicine group(group B) ,each group 100 cases.B group was conducted with the general anti - inflammatory, dehydration, nerve pain and nutritional therapy,and A group was given the traditional Chinese medicine treatment on the base of B group.After 3 weeks treatment, the curative effect, VAS score and hospital stay were observed.Results A total effective rate 90.0% in group A was higher than B group 73.0% ( x2 = 3.987 ,P < 0.05); The scores of VAS after treatment 4 weeks[(1.1 ±1.23、0.9 ±0.6)/point]were lower than before treatment[(8.6 ± 1.43,8.8 ± 1.382)/point]in two groups(t =2.301,2.335,all P<0.05) ;The scores of VAS after treatment 3d and 1 week in group A[(5.5 ±0.92) point,(2.7±1.14) point] were lower than group B[(8.2 ±0.59) point,(5.3 ±0.91) point] (t =2.405,2.435,all P<0.05);The hospital days(20.1 ±3.5)d in group A was significantly lower than group B(27.6 ±4.3)d( t = 2.314,P <0.05).Conclusion Western combined with traditional Chinese medicine had better clinical efficacy in teatrent of patients with acute lumbar disc hemiation.

BACKGROUND: Mental health problem is directly correlated with the health and happiness of the elders, and to improve their health level has become a social problem. OBJECTIVE: To investigate the mental health and social support status of the elders in Lishui city. DESIGN: A sample investigation. SETTING: Lishui Center for Disease Prevention and Control.PARTICIPANTS: Totally 137 retirees or honored retirees above 55 years in a community in Liandu district and 136 people above 55 years in a village in Bihu township of Liandu district were taken as the urban and a rural samples respectively in September and October 2003. METHODS: The symptom checklist-90 (SCL-90) and social support rating scale (SSRS) were used. The questionnaires were dispatched, measured and collected by the local physicans in rural area and community cadres in urban area in household anonymously on the spot. MAIN OUTCOME MEASURES: ① Scores of SCL-90 and SSRS in both groups; ② Correlations between social support factors and mental health factors in the elders between urban and rural communities; ③ Comparison of the most common 10 symptoms in SCL-90 between urban and rural elders; ④ Comparison of SCL-90 scores among different age groups and between males and females.RESULTS: Totally 380 questionnaires were sent out, 273 effective ones were collected back, and the collected rate was 71.84%. ① The differences of factor scores in SCL-90 were all significant or markedly significant (P ＜ 0.05-0.01) except that of depression, and all the factor scores in both urban group and rural group were obviously lower than those of national norm (P ＜ 0.01). The differences of subjective support and utilization of support in social support status between the two groups were of marked significance (P ＜ 0.01), whereas the differences of objective support and total scores were not so obvious (P ＞ 0.05). ② The correlation ananlysis between social support and mental health factors in the rural group showed that the utilization of support had no significant correlation with factors of anxiety, hostility, phobic anxiety, paranoid ideation and psychoticism, whereas the other three dimensions and other 10 factors showed significant or very significant correlation. The correlation ananlysis between social support and mental health factors in the urban group showed that there was no significant correlation of objective support with the symptoms of obsession-compulsion and psychoticism, as well as between the utilization of support and the symptom of obsession-compulsion,whereas other dimensions of support showed significant or very significant correlation with other factors. ③ The most common positive symptom with the highest incidence rate was high forgetfulness (79.4%) in the rural group and muscular ache (69.3%) in the rural group, respectively. ④ The scores of interpersonal sensitivity, anxiety, hostility, phobic anxiety, paranoid ideation and psychoticism were lower in the ≥70 years old group than in the ＜ 70 years old group (P ＜ 0.05-0.01); there were no significnat gender differences (P ＞ 0.05).CONCLUSION: The mental health of the elders in Lishui city is slightly better than that of national norm, and it is better in rural area than in urban area. But the existed mental problems should not be ignored. The mental health status is greatly and directly related with the factor of social support, so the major and important measure to improve the mental health of the elders is to better the environment of social support and take effective psychological interference.