With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

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OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

OBJECTIVE: To investigate the dissolution in vitro of cefradine capsules from seven pharmaceutical factories for clinical reference in drug choice. METHODS: The dissolution tests were carried out using basket-rotating method. UV spectrophotometry was used to determine the concentration of cefradine. The cumulative dissolution was calculated and dual-index model was used to fit the dissolution parameters (a, b, Td, and T80). The differences among groups were statistically evaluated by variance analysis. RESULTS: The dissolution in vitro of cefradine capsules from seven different pharmaceutical factories were all up to the related standards specified in Chinese Pharmacopoeia(2005 edition). But significant differences were noted in dissolution parameters a,b,Td and T80(P

OBJECTIVE: To investigate the general regularity and characteristics of allergic shock which was caused by Mailuoning injection so as to prevent its recurrence and promote the rational use of drugs. METHODS: ADR reports about anaphylactic shock induced by Mailuoning injection which were publicly published in medical journals in China during 1994 Jan～2009 June were retrieved and analyzed statistically. RESULTS: A total of 31 cases of anaphylactic shock induced by Mailuoning injection included 1 death case, of which 21 cases were in males and 10 in females. Anaphylactic shock mostly occurred within 10 min after administration with a total of 25 cases. 25 cases occurred among patients aged above 40 years accounted for 83.87% in total. CONCLUSION: There are many correlated factors that allergic shock is induced by Mailuoning injection with serious consequence. So doctors and pharmacists should pay more attention to it.

OBJECTIVE:To probe into the category and drug resistance of clinically isolated gram-positive bacterium(G+)in our hospital. METHODS:The category and drug resistance of clinically isolated gram-positive bacterium(G+)in our hospital in the recent five years were surveyed and analyzed retrospectively. RESULTS:Of clinical isolated gram-positive bacterium(G+), Staphylococcus accounted for 65.47% and Enterococcus 20.24%. Majority of Staphylococcus were coagulase negative Staphylococcus,followed by Staphylococcus aureus. The most of Enterococcus were Enterococcus faecium and Enterococcus faecalis. The drug resistance rates of Staphylococcus to nitrofurantoin and ifampin reached low level and the sensitivity of Staphylococcus to vancomycin was 100%. There was difference between drug resistance of Enterococcus faecium and Enterococcus faecalis. Vancomycin has better effect than other drugs on Enterococcus. CONCLUSIONS:Doctors must pay attention to the component and drug resistance of bacteria so as to improve the application of antibiotics.

OBJECTIVE:To provide reference for rational application of typeⅡpsychotropic drugs. METHODS:The applica-tion of type Ⅱ psychotropic drugs in our hospital during 2012-2014 was analyzed statistically in respects of consumption sum,con-sumption amount,DDDs,DDC,etc. The trend of the application of type Ⅱ psychotropic drugs and the reasonability of medication structure were evaluated in our hospital. RESULTS:9 type Ⅱ psychotropic drugs were used in our hospital during 2012-2014,in-cluding 5 oral preparations and 4 injections. The consumption sum of drugs during 2012-2014 were 22 551.33 yuan,31 489.95 yu-an and 57 742.87 yuan,increasing by 39.64% in 2013 and 83.37% in 2014. The number of type Ⅱ psychotropic drugs increased year by year,and the amount of estazolam was the largest and took up the first place in 3 years. DDDs of estazolam also occupied the first place in the list of DDDs. DDC of Phenobarbital tablet was the smallest. CONCLUSIONS:Type Ⅱ psychotropic drugs mainly are oral drugs and reasonable in structure in our hospital during 2012-2014. The consumption sum and amount of type Ⅱpsychotropic drugs increase reasonably year by year.

Multiple myeloma (MM) is a hematological malignancy. Osteolytic lesion is the commonest complication in patients with MM. Skeletal-related events severely affect the survival quantity and prognosis. Current therapeutic approach for the treatment of myeloma bone disease (MBD) is based on the use of bisphosphonates. AS the recent advance in the pathogenesis and therapeutics of MBD,more factors related to this disease are found. In this article important factors related to the pathogenes of MBD and the cytokine targeted therapies are reviewed.

Objective To investigate clinical efficacy and safety of half quantity of tirofiban on elderly patients with ST segment elevation myocardial infarction ( STEMI ) .Methods 120 elderly patients with STEMI underwent emergency PCI patients,120 cases of digital method were randomly divided into the control group and observation group,60 cases in the control group with conventional surgery and drug treatment,the observation group of 60 cases on the basis of conventional therapy was given to half the amount for tirofiban,the two groups were observed in the risk of bleeding, the occurrence of adverse cardiovascular events after operation.Results The postoperative bleeding risk of the observation group compared with the control group had no significant difference(χ2 =1.51,1.35, 0.94,P=0.643,0.768,0.578);for the observation group in 30 days after operation,90 days of re infarction,death and target vessel revascularization rate compared with the control group decreased,the difference was statisticallysig-nificant(30 days after operation,χ2 =9.54,18.33,16.75,P=0.043,0.029,0.031;90 days after operation,χ2 =17.48,21.78,19.54,P=0.034,0.011,0.021).Conclusion Semi quantity for tirofiban can reduce the risk of elderly patients with STEMI after PCI,improve clinical outcome,which will not increase the risk of hemorrhage.

36 children of exotropic amblyopia, 20 of constant exotropia and 16 of intermittent exotropia, were performed multi-channel VEP examinations to find that all amplyopic eyes manifested VEPs of lower amplitude and longer latency. With full-field stimulation to both eyes, summation of VEP was absent in the group of constant exotropia while it was weakly present in the group of intermittent exotropia. With half-field stimulation, temporal retinal suppression was noted in all healthy eyes and some of the amblyopic eyes of the intermittent exotropia group while it was absent in the amblyopic eyes of the constant exotropia group.