OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

Acquired Immunodeficiency Syndrome ; prevention & control ; China ; Humans ; Infectious Disease Medicine ; methods ; trends

Disease Outbreaks ; Humans ; Influenza, Human ; epidemiology ; prevention & control

Acquired Immunodeficiency Syndrome ; prevention & control ; China ; Delivery of Health Care ; standards ; Health Services ; standards ; Humans ; Severe Acute Respiratory Syndrome ; prevention & control

Objective To investigate the application effect of intensified nursing intervention in severe pneumonia complicated with ventilator-associated pneumonia. Methods 78 senile patients admitted to hospital with severe pneumonia complicated with ventilator-associated pneumonia from November 2009 to November 2010 were chosen as the research object.They were randomly divided into the observation group and the control group with 39 cases in each group.The control group was treated with conventional and comprehensive methods of care.The observation group was taken intensified intervention on the basis of the control group.The utility time of ventilator after complication with ventilator-associated pneumonia,hospital stay time,complications and mortality rate for the two groups were compared. Results The utility time of ventilator,hospital stay time,complications and mortality rate for the two groups were compared.The observation group had a clear advantage over the control group,there was significant difference. Conclusions Nursing intervention can be targeted to enhance the improvement of the overall respiratory status in severe pneumonia complicated with ventilator-associated pneumonia.It contributes to inflammation control,and can reduce utility time of ventilator and length of hospital stay,reduce the corresponding incidence of complications and mortality rate,it is worthy of clinical application.

The article is intended to introduce the readers to the concept and background of Web accessibility in the United States. I will first discuss different definitions of Web accessibility. The beneficiaries of accessible Web or the sufferers from inaccessible Web will be discussed based on the type of disability. The importance of Web accessibility will be introduced from the perspectives of ethical, demographic, legal, and financial importance. Web accessibility related standards and legislations will be discussed in great detail. Previous research on evaluating Web accessibility will be presented. Lastly, a system for automated Web accessibility transformation will be introduced as an alternative approach for enhancing Web accessibility.

Objective To study the curative effect of accessory breast resection with axillary minidermato-glyph incision.Methods The clinical data of 47 patients undergoing accessory breast operation in our hospital be-tween April 2010 and June 2014 were retrospectively analyzed according to different methods of operation.They were divided into two groups:26 cases with axillary minidermatoglyph incision as the observation group and 21 cases with conventional accessory breast resection as the control group.The postoperative wound healing and incidence of com-plications were then compared.All the patients were followed up for 6 months.Self-designed questionnaire of visual simulation effects were adopted and shape, local pain and upper extremity activities were evaluated by the patients. Results The two groups had no significant difference in the unilateral average operation time (p >0.05).The bleeding volume in the observation group was less than the control group, and the average length of the incision and the average hospital stay were significantly shorter than those of the control group (p<0.05).After 6 months of fol-low-up, the basic satisfaction rate of shape of patients in the observation group was 95.15%, upper extremity activi-ty reached 100%, and the rate of local painlessness was 95.15%, both higher than the control group (p<0.05). Conclusion Accessory breast resection with axillary minidermatoglyph incision has the advantages of reliable cura-tive effect, less damage, inconspicuous local scar and no significant effect on physical activity.

Objective:To evaluate the diagnostic value of MSCT for small intestinal stromal tumors.Methods: The MSCT results of 27 cases diagnosed pathologically as small intestinal stromal tumors were retrospectively analyzed.Results: MSCT scan could clearly show the position, size, shape, fat space, density, calcification, growth pattern of the lesions. Enhanced MSCT scan showed that the arterial phase was significantly strengthened, the venous phase was significantly enhanced than the arterial phase, and the delay phase was significantly enhanced than the venous phase. Low-risk tumors were mainly with maximum diameter <5 cm, regular shape, clear fat gap, uniform density, and intraluminal growth-oriented, while high-risk tumors were mainly with maximum diameter ≥5cm, irregular shape, blur fat gap, uneven density, and cavity shape and mixed growth. The differences were statistically significant (x2=6.64,P<0.05).Conclusion:MSCT can be used as a preliminary judgement for benign and malignant small intestinal stromal tumors and its level, which can guide further clinical treatment and prognosis evaluation.

Multiple myeloma (MM) is a hematological malignancy. Osteolytic lesion is the commonest complication in patients with MM. Skeletal-related events severely affect the survival quantity and prognosis. Current therapeutic approach for the treatment of myeloma bone disease (MBD) is based on the use of bisphosphonates. AS the recent advance in the pathogenesis and therapeutics of MBD,more factors related to this disease are found. In this article important factors related to the pathogenes of MBD and the cytokine targeted therapies are reviewed.