With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

Acquired Immunodeficiency Syndrome ; prevention & control ; China ; Humans ; Infectious Disease Medicine ; methods ; trends

Disease Outbreaks ; Humans ; Influenza, Human ; epidemiology ; prevention & control

After the application of project-based teaching in medical information retrieval course for grade two un-dergraduates of Guangzhou Medical University Vocational Health Technology School was described , the examination records were compared between project-based teaching group and traditional teaching group with the problems sum-marized and measures proposed for their solution .

The concept of autoinflammatory diseases and autoimmune diseases is different but similar.With the genetic background and inflammation pathways of many autoimmune diseases elucidated,some kinds of diseases are facing a new partition.The explaination of immunological disease continuum update the concept of some diseases and benefit from the treatment.

Objective To compare the effect of laparoscope and open operation in the treatment of acute perforation of peptic ulcer.Methods Clinical data of 56 peptic ulcer patients were retrospectively analyzed.30 patients (group A) received laparoscopic treatment,26 cases(group B) received traditional open operation treatment.Operation time,hospitalization time,postoperative exhaust time,ambulation time,frequency of using analgesics after operation,incidence rate of complications and the cost of hospitalization were compared between the two groups.Results In A group,the hospitalization time was (4.5 ± 1.4) d,postoperative exhaust time was (23.9 ± 7.2) h,time to ambulation was (14.1 ± 5.6)h,frequency of postoperative analgesic use was 16.7％,the incidence rate of complications was 0,which were better than those in the control group(11.6 ± 7.5) d,(37.6 ± 17.9) h,(43.4 ± 11.8) h,92.3％,19.2％ (t =4.23,4.54,6.32,x2 =3.78,4.45,all P ＜ 0.05).Operation time,white blood cell count and cost of hospitalization between two groups showed no significant differences(P ＞ 0.05).Conclusion Laparoscope in treatment of acute perforation of peptic ulcer has advantages of less trauma,less complications,quicker recovery,shorter hospitalization time and good clinical effect.This operation mode is relatively ideal,and is worth the clinical promotion.

Objective To investigate the application effect of intensified nursing intervention in severe pneumonia complicated with ventilator-associated pneumonia. Methods 78 senile patients admitted to hospital with severe pneumonia complicated with ventilator-associated pneumonia from November 2009 to November 2010 were chosen as the research object.They were randomly divided into the observation group and the control group with 39 cases in each group.The control group was treated with conventional and comprehensive methods of care.The observation group was taken intensified intervention on the basis of the control group.The utility time of ventilator after complication with ventilator-associated pneumonia,hospital stay time,complications and mortality rate for the two groups were compared. Results The utility time of ventilator,hospital stay time,complications and mortality rate for the two groups were compared.The observation group had a clear advantage over the control group,there was significant difference. Conclusions Nursing intervention can be targeted to enhance the improvement of the overall respiratory status in severe pneumonia complicated with ventilator-associated pneumonia.It contributes to inflammation control,and can reduce utility time of ventilator and length of hospital stay,reduce the corresponding incidence of complications and mortality rate,it is worthy of clinical application.

Objective To explore the clinical efficacy of laparoscope in the treatment of nulliparous women with tremendous ovarian cysts .Methods 46 cases of nulliparous women were divided into the two groups according to the operation method .23 cases in the laparoscopic surgery group received laparoscopic pneumoperitoneum needle treatment.23 cases in the open group were given the traditional open surgery .Before operation,the umbilical region and vagina of these patients were cleaned ,and antibiotics was given to the two groups .The operative time,postopera-tive bleeding,exhaust time,hospitalization time,the number of cases of postoperative pain ,menstrual conditions and recovery time of daily living activities were compared .Results The operative time of the laparotomy group was (68.3 ±12.3)min,which was significantly longer than (59.6 ±11.5)min of the laparoscopic surgery (t=4.26,P<0.05).The number of pain after surgery in the laparoscopic surgery group and laparotomy group were 11 cases,21 cases. The incidence rate of postoperative pain in the laparoscopic surgery group was 47.8%,which was significantly lower than 91.3% in the laparotomy group (χ2 =10.3,P<0.05).Conclusion Laparoscopic treatment for nulliparous women with ovarian cysts showed shorter operative time ,less blood loss ,faster exhaust time ,shorter hospital stay ,less pain and faster recovery .This surgery scheme deserved to be introduced and further studied .

HIV/AIDS has been circulating in China for over 25 year. While making progress and achievements on HIV/AIDS prevention, there still are great challenge and difficulties such as HIV epidemic controlling and vaccine research.