1.Effects of RPPS on lymphocyte transformation and NK activity in mice
Chinese Pharmacological Bulletin 1986;0(04):-
Taking Radix Phodiolae polysac-charides (RPPS) which was extrated from Radix Phodiolae native to Tibet, and using the immunosuppresive mice model, induced with Cy (cyclophosphamide), this paper investigated effects of RPPS on the WBC numbers and Hb content of perpheral blood, thymus weight and cell-mediated immunity of mice. It was found that RPPS had no obvious effects on WBCnumbers and thymus weight, and could decrease the content of Hb in normal mice while it increased the content of Hb in immunosuppresive mice. RPPS not only could enhance lymphocyte transformation and NK activity in normal mice but also could reverse the decrease of the above indexes in immunosuppresive mice. The results suggested that RPPS be a new biological response modifier.
2.Clinical control study on 350 cases of advanced non-small cell lung cancer(NSCLC) treated with Xie's Feiai No.1 formula
Jianguo XIE ; Yuzi LIU ; Fenghua HE ; Xiaoyun ZHANG ; Xiaoman XU ; Qijuan YANG ; Ye WU ; Fanzhen MENG ; Cong ZHANG
International Journal of Traditional Chinese Medicine 2011;33(3):196-199
Objective To observe the clinical effects of Xie's Feiai No.1 formula on patients with advanced non-small cell lung cancer (NSCLC) and its influence on body immune system, VEGF (blood vessel endothelia growth factor) and CYFRA21-1 (keratoprotein 21-1). Methods 650 cases of advanced NSCLC were randomized into a treatment group and chemotherapy group, with 350 cases and 300 cases in each group respectively. The treatment group was administrated with Xie's Feiai No.1 formula, while the chemotherapy group was treated with chemotherapy ofGP plan/TP plan. Both groups were treated for 2 months. Results The short-term effective rate was 56.57% in the treatment group, which was superior to 44.33% (P<0.01) in the chemotherapy group; Steady rate KPS score improvement was 85.14% in the treatment group, which was also higher than 27.00% (P<0.01) in the chemotherapy group; besides the levels of total T cell, adjuvant T cell and NK cell in the treatment group were higher than the chemotherapy group, while the levels of Ts cell, VEGF and CYFRA21-1 int the treatment group were lower than the chemotherapy group. Long-term efficacy observation showed that the survival rate of 117 cases with advanced NSCLC was 83.59% in one year and 46.27% in three years in the treatment group, both significantly higher than those in the chemotherapy group (P<0.01).Conclusion Xie's Feiai No.l formula can increase NSCLC patients' survival time, improve quality of life, strengthen immunological function and restrain tumor cells' activities.
3.A case of early-onset spinocerebellar ataxia type 5
Yuzi ZHANG ; Ting SHEN ; Shixiong YANG ; Hansong WU ; Yuxin LIU
Chinese Journal of Neurology 2022;55(12):1389-1392
Spinocerebellar ataxias are a high clinically and genetically heterogeneous group of neurodegenerative disorders, usually belongs to autosomal dominant hereditary cerebellar ataxia. Spinocerebellar ataxia type 5 (SCA5) is one of the extremely rare subtypes and caused by heterozygous mutation of SPTBN2 gene. A case of infant-onset SCA5 patient is reported, mainly manifested as global developmental delay, ataxia and dysarthria, carrying the heterozygous missense variant c.1438C>T (p. Arg480Trp) in the SPTBN2 gene. This mutation may have an important impact on functional regions of the β-Ⅲ spectrin, leading to the occurrence of disease.
4.Effect of body mass index on disease-free and overall survival in Chinese women with breast cancer.
Yuzi ZHANG ; Qing QU ; Yan MAO ; Kunwei SHEN ; Email: KWSHEN@MEDMAIL.COM.CN.
Chinese Journal of Oncology 2015;37(5):395-399
OBJECTIVEObesity has been shown to be an indicator of poor prognosis for patients with primary breast cancer. The aim of this study was to clarify the effect of obesity on Chinese women with breast cancer.
METHODSThis is a retrospective analysis of 1699 breast cancer patients. We evaluated the effect of body mass index (BMI) on disease-free survival (DFS) and overall survival (OS) in these patients. BMI was obtained before surgery. Obesity was defined as a BMI ≥ 24. Kaplan-Meier analysis and Log rank test were employed to perform survival analysis. The impact of different characteristics on survival was assessed by using Cox proportional-hazards regression model.
RESULTSIn total 635 (37.4%) patients were obese, while 1 064 (62.6%) were non-obese. Comparing the tumor characteristics in the two groups, the BMI ≥ 24 group showed a higher rate of older age (P < 0.001), postmenopausal status (P < 0.001), increased risk of lymph node metastasis (P = 0.001) and less chances of accepting breast conservation surgery (P = 0.012). The median follow-up time was 16 months, and the estimated 16-months DFS was 98.1% for non-obese and 95.0% for obese patients (P = 0.007), the estimated 16-months OS was 99.4% for non-obese and 98.4% for obese patients (P = 0.004). The multivariate analysis indicated that obesity is an independent prognostic factor for OS and DFS in breast cancer patients.
CONCLUSIONSOur findings suggest that obesity is associated with a poorer outcome in Chinese female patients with breast cancer.
Body Mass Index ; Breast Neoplasms ; epidemiology ; China ; epidemiology ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Obesity ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Survival Analysis
5.New-concept animal vaccines emerging in recent years.
Tengteng ZHANG ; Yuzi LUO ; Yuan SUN ; Taiyuan LI ; Hua-Ji QIU
Chinese Journal of Biotechnology 2018;34(12):1963-1973
Animal infectious diseases pose a serious and continuing threat to the animal health and cause huge economic losses throughout the world. Vaccination is one of the most effective solutions to prevent and control animal infectious diseases. With the development of biotechnologies and the need for disease prevention and control, the focus of vaccine research has been shifted to the development of safe, efficient, broad-spectrum, low-dose and marker vaccines. Novel vaccines capable of inducing high levels of both humoral and cellular immune responses are promising to provide more efficient protection against animal infectious diseases. This minireview summarizes the development, applications, advantages and disadvantages of new-concept animal vaccines emerging in recent years, including mucosal vaccines, long-acting and fast-acting vaccines, chimeric vaccines, nanoparticle vaccines, and so on. Furthermore, we discuss future directions of the vaccines, in order to provide new insights for animal vaccine development.
Animals
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Communicable Diseases
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Immunity, Cellular
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Nanoparticles
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Vaccination
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Vaccines
6. Hippocampal neuronal ferroptosis involved in cognitive dysfunction in rats with sepsis-related encephalopathy through the Nrf 2/GPX4 signaling pathway
Peng YAO ; Yong CHEN ; Yiling LI ; Yuzi ZHANG ; Hao QI ; Wenhao XU
Chinese Critical Care Medicine 2019;31(11):1389-1394
Objective:
To evaluate the effects of ferroptosis in hippocampal neurons on cognitive dysfunction in rats with sepsis-associated encephalopathy (SAE) and its potential molecular mechanisms.
Methods:
① Screening experiment of SAE modeling conditions: 42 healthy male Sprague-Dawley (SD) rats were divided into normal saline (NS) control group (