We utilized the mass-acceleration concept according to Newton'a second law of motion to establish a mathematieal model of left ventricular active diastolic force by twodimensional and Doppler echocardiography. Twenty normal control subjects and 31 patients with coronary heart diseases were tested. The results showed that the left ventricular active diastolic force of the patients with coronary heart diseases was significantly lower than that of the control group(P<0.001).The authors believe that left veatricular active diastolic force is a reliable candidates for assessing the left ventricular diastolic function.

Objective To explore the relationship of the mean color vessels density (MCVD) and pathologic microvessel density(MVD) in rectal cancers and their relation with T stags and lymph node metastasis.Methods MCVD were caculated preoperationly with transrectal color power angiography(TRCPA).After operation MVD was assessed immunohistochemically using anti-CD105 monoclonal antibody.The relationships within MCVD, MVD and T stages and lymph node metastasis were analysed.Results There were positive correlation between MCVD and MVD (r=0.763, P＜0.01) in rectal cancer.There were significant difference of MCVD and MVD in both the depth of carcinoma invasion and metastasis of lymphatic nodes( P＜0.05).Conclusions MCVD can display features of the blood supply and distribution of pathologic microvessels and reflect the development of rectal cancers.MCVD is a credible index to choose available treatment and to evaluate prognosis before operation of rectal cancer.

Objective To discuss the diagnostic value of distal subclavian artery flow velocity tracing for proximal segment severe stenosis.Methods 56 cases with 112 subclavian arteries were examed by ultrasonography and multidetector CT angiography respectively,then the flow velocity tracing of distal subclavian arteries had been compared with CT results.Results In all 112 subclavian arteries,there were 37without proximal segment stenosis,32 with mild stenosis,12 with moderate stenosis,and 31 with severe stenosis.Innominate arteries and other parts of subclavian arteries had no stenosis.In diagnosis of subclavian artery proximal severe stenosis using single phase single peak waveform,the sensitivity,specificity,positive likelihood ratio,and negative likelihood ratio were 83.9 ％,96.3 ％,22.7,0.063 respectively.The sensitivity,specificity,positive likelihood ratio,and negative likelihood ratio were 100 ％,93.8 ％,16.1,0 respectively,in terms of diagnosis by application of acceleration time ≥0.11s.Conclusions The statistics of acceleration time ≥0.11 s and single phase single peak waveform have high application value in diagnosis of subclavian artery severe stenosis respectively.

Objective To investigate the correlation between shear wave velocity and tissue fibrosis score in thyroid space-occupying lesions.Methods The shear wave velocity of 55 thyroid space-occupying lesions was examined by virtual touch tissue quantification.The shear wave velocity of different solid parts of the lesions was detected for several times and 15 data were genarated.Then maximum and minimum value were removed.The maximum (Vmax),minimum (Vmin),mean (Vm) of shear wave velocity were calculated with the rest of 13 data.Meantime the fibrosis degree of these pathological lesions were scored by using optical micorscope.The maximum (Fmax),minimum (Fmin) and mean (Fm) fibrosis degree were calculated with these scores.Then the difference between Fmax,Fmin and Fm value of benign lesions and malignant lesions was analyzed.The linear correlation between Fmax and Vmax,Fmin and Vmin,Fm and Vm was also analysed.Results In the 55 lesions,30 lesions were benign and the rest was malignant.The Fmax,Fmin,Fm of benign lesions were 1.38 ± 1.44,0.68 ± 0.25,0.91 ± 0.73 respectively; the corresponding value of malignant lesions were 5.00 ± 1.91,3.52 ± 1.82,4.08 ± 1.75 respectively.There was significant difference between the benign group and malignant group (t test,P ＜0.01).There were linear correlation between Fmax and Vmax,Fmin and Vmin,Fm and Vm and the Pearson correlation coefficients were 0.504,0.284,0.453 respectively.Conclusions The shear wave velocity and fibrosis degree of thyroid lesions has linear relationship.The heavier the degree of fibrosis is,the faster the shear wave velocity would be.

0.05).②The ophthalmic artery showed a significant increase in Vs and PI,RI 1 week postoperatively(P 0.05).Conclusions Two horizontal rectus muscle operations do cause significant hemodynamic changes in the ophthalmic artery 1 week postoperatively,but these changes in the ophthalmic artery revive normal 1 month postoperatively.

OBJECTIVE To evaluate the clinical effects and toxicity of netilmicin with different administrations by de?termining its serum concentration in the treatment of lower respiratory tract infection.METHODS:22cases of lower respi?ratory tract infection were randomly divided into two groups.The drug serum concentrations were determined by TDx system.Clinical effects were compared;renal function and hearing ability were monitored.RESULTS:On the condition of the same total daily dosage,the peak concentrations in once-daily group(group QD)were significantly higher than those in twice-daily group(group BD)(P

AIM To investigate the effect of tamoxifen on the proliferation of the anterior pituitary cell of rats and its mechanism. METHODS Primary culture of the anterior pituitary cell of rats and 3H TdR incorporation method were applied. The changes of cell morphology were observed directly by electric microscope. RESULTS Tamoxifen could inhibit the proliferation of the anterior pituitary cell of rats. The inhibitory effect of tamoxifen (0 1 ?mol?L -1 ) could be reversed by estrogen.The classical apoptotic changes appeared in the cells after tamoxifen incubation for 48 h. CONCLUSION Tamoxifen can inhibit the proliferation of the anterior pituitary cell of rats and resultin the cell apoptosis.

The crystal structural data of TACE, MMP-1, MMP-2, MMP-3 and MMP-9 were obtained from PDB database, and then their catalytic domains' properties including conformation, molecular surface hydrophobicity and electrostatic potential were analyzed and compared by using Insight II molecular modeling software. It was found that the conformation and molecular surface hydrophobicity of catalytic domains of TACE and MMPs were not obviously different, but the molecular surface electrostatic potential of catalytic domain of TACE and MMPs had obvious differences. The findings are helpful in the Rational Drug Design of TACE selective inhibitor.

Objective To compare the value of automatic breast volume scanner (ABVS) with enhanced magnetic resonance imaging(MRI) in the diagnosis of breast masses.Methods Seventy-four patients with 80 breast masses underwent preoperative ultrasound examinations including ABVS and MRI.The values of ABVS and MRI in the diagnosis of breast masses were comparatively analyzed.Results Among the 80 breast masses that were surgically removed,37 masses were benign and 43 masses were malignant.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of ABVSin the diagnosis of breast malignant masses were 94.6％,79.1％,86.3％,79.5％ and 94.4％,respectively,those of MRI were 94.6 ％,86.0 ％,90.0 ％,85.4 ％ and 94.9 ％,respectively,and those of the combination of ABVS and MRI were 94.6％,93.0％,93.8％,92.1％,and 95.2％,respectively.The sensitivity and specificity were not significant difference between ABVS and MRI in the diagnosis of breast malignant masses(P ＞0.05).The specificity of the combination ABVS and MRI in the diagnosis of breast malignant masses were significantly higher than that of ABVS (x2 =4.17,P =0.04).The sensitivity,specificity and accuracy of convergence sign in the diagnosis of breast malignant masses were 64.9 ％,97.7 ％ and 82.5 ％,respectively.Conclusions ABVS and MRI are both valuable in the diagnosis of breast masses,and the combination of ABVS and MRI is the most valuable due to high specificity.

Objective To compare the clinic significance of four clinical scoring systems in evaluating prognosis of acute pancreatitis: bedside index for severity in acute pancreatitis(BISAP), acute physiology and chronic health evaluation (APACHEⅡ), Ranson’s scoring system, computed tomography severity index (CTSI) in AP. Methods Patients visited our clinic with AP (n=114) in recent 2 years were retrospectively analyzed. BISAP and APACHEⅡscores were obtained at 24 hours after admission; Ranson ’s score was obtained at 48 hours after admission and CTSI are obtained was obtained at 72 hours after admission. Results of four scoring system were compared under different causes and different severity of the dis?ease. Correlation between BISAP score and the other three scores were analyzed and the predicative value of all four scoring systems for severity of AP and death were also compared. Results The mean values of four scoring systems show no signifi?cant difference in AP patients with different etiology (P>0.05). The BISAP score is positively correlated with APACHE-Ⅱ, Ranson ’s score and CTSI score (P<0.01). The four scoring systems all present good predictive value on the severity of AP and death (P<0.01). Conclusion The four scoring systems can all be applied to grading and prognosis for AP of various causes. BISAP is a simple, prompt, economical scoring system in clinical practice.