Reticular macular disease (RMD) is a novel, independent macular disease closely related to age-related macular degeneration (AMD). It is currently available to identify RMD through a variety of new imaging techniques.The infrared imaging in the confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography have the highest sensitivity and specificity for the diagnosis of RMD, and the imaging characteristics are significantly different from those of the common drusen.The cause of RMD has a certain correlation with genes, environment, gender, age and systemic diseases, but the specific pathogenesis is still inconclusive.Many studies showing that choroid vascular lesions are closely related, and Bruch membrane lesions may also be the cause of the first appearance of reticular pseudodrusen in some studies.RMD is closely related to advanced AMD, especially geographic atrophy, and some develop advanced wet-AMD.Early intervention may prevent its progression to advanced AMD.In recent years, it has been found to be associated with cardiovascular diseases and some malignant tumors, and may even become a warning sign.Therefore, research on RMD is of increasing importance in clinical implications.In this article, the characteristics of RMD, its clinical and imaging manifestations, changes of visual function and its relationship with fundus and systemic diseases were reviewed.