Objective To investigate the relationship between EVI1 gene expression and clinical features and prognosis of children with acute myeloid leukemia (AML). Methods EVI1 gene was detected in AML children, correlation of clinical and lab features, prognosis of AML children with EVI1 gene were analyzed. Results EVI1 expression is positive in 38 of 145 children with AML. There were no significant differences in age, gender, hemoglobin concentration, leukocytes and platelet count, subtype of morphology, ratio of chromosomal anomaly and complex karyotypes between EVI1 positive and EVI1 negative group (P>0.05); coexist genes were detected in 9 cases (23.68%) of EVI1 positive group. Rate of complete remission (CR) was 91.67% in 24 cases of EVI1 positive patients received chemotherapy. Relapse rate was 64.29% and 14.29% in EVI1 positive patients who received chemotherapy and allo-hematopoietic stem cell transplantation (allo-HSCT), retrospectively and significant differences were found (P<0.05). There was no significant difference in CR but significant difference was found in event free survival (P<0.05) for EVI1 positive and EVI1 negative patients who received chemotherapy. EVI1 gene kept negative when bone marrow relapse occurred in two patients with EVI1 positive at diagnosis. Conclusion EVI1 gene may play adverse role in pediatric AML; prognosis of EVI1 positive AML patients can be improved by allo-HSCT; follow-up of EVI1 transcript levels is insufficient to monitoring of minimal residual disease.

To analyze the lesion distribution situations and relationship of lesions detected by gastroscopy and colonoscopy in asymptomatic population in Beijing. Data of 1 663 patients who received gastroscopy and colonoscopy in the physical examination center of Peking Union Medical College Hospital and Beijing Hospital between January 2016 and December 2018 were analyzed retrospectively. Statistical analysis was conducted on the detection rate and relationship of different lesions based on the information of gender and ages. Gastroscopy data showed that chronic non-atrophic gastritis and chronic atrophic gastritis accounted for 1 240 (74.6%)and 423 (25.4%)cases respectively. Chronic atrophic gastritis was more common in population aged over 40. Other common diseases included erosions of gastric body and/or antrum, fundic gland polyps, reflux esophagitis, duodenitis, bile regurgitation and so on. Upper gastrointestinal tumors including esophagus cancer and gastric cancer were both early lesions. Colonoscopy results showed that colonic polyps were common lesions, among which there were 382 (23.0%)cases of colonic adenoma and 217 (13.0%)hyperplastic polyps. Incidence of colonic polyps increased with age. Colorectal cancer accounted for 0.7%. Colon diverticulum and melanosis coli were more common in population aged over 40. Colon adenoma was more common in male and melanosis coli was more common in female. The positive rate of HP was 32.2%. There was no positive relationship between HP infection and fundic gland polyps( P=0.329). There was no positive relationship between fundic gland polyps and colon adenomas as well as colorectal cancer( P=0.152, P=0.616). Gastroscopy and colonoscopy play important roles in different kinds of digestive diseases, especially in the early detection of tumors. More attention should be paid to the application of endoscopy in asymptomatic population.

Objective To evaluate the intervention effects of systemic rehabilitation training on postoperative disuse shoulder dysfunction in hand injury patients received abdominal pedicled skin flap transplantation. Methods The 92 patients received same operation of abdominal pedicled skin flap surgery for unilateral hand in Hand and Foot Surgery Department of Provincial Hospital Affiliated to Shandong University and were divided into two groups, in which 45 patients as control group from March to April 2014 and 47 patients as experimental group from June to July 2014. The patients of control group received conventional therapy and nursing, while the ones of experimental group received systematic rehabilitation training by nurses and doctors before, during and after operation. Shoulder function was scored at the day 1 and day 7 after the pedicle division operation according to the shoulder joint function assessment scale, and we employed SPSS 20. 0 to analyze the results. Results The shoulder function scores of experimental group patients were (72. 96 ± 4. 72) and (87. 91 ± 4. 74) at the day 1 and day 7 after the pedicle division operation, which were better than the scores of control group patients, [(65. 11 ± 6. 74) and (79. 38 ± 7. 31)] (t =6. 492,6. 677;P <0. 01). Conclusions The systemic rehabilitation training program, which requirements were definite, and guidance was standard and easy to perform, can significantly improve the shoulder function of the patients received abdominal pedicled skin flap transplantation.

Objective:To explore the application effect of nursing intervention based on COX's interaction model of client health behavior (IMCHB) in outpatient colonoscopy patients.Methods:Using the convenient sampling method, a total of 209 patients who underwent colonoscopy at the Digestive Endoscopy Center of International Medical Department in Peking Union Medical College Hospital from March 2019 to August 2019 were selected as the research objects. They were divided into the control group (103 cases) and the intervention group (106 cases) according to the order of examination date. The control group received basic nursing intervention according to routine requirements, while the intervention group implemented nursing intervention based on COX's IMCH on the basis of the control group. The medication compliance, occurrence of adverse reactions and satisfaction of patients' experience in medical treatment were compared between the two groups.Results:The medication, diet and exercise compliance of the intervention group during bowel preparation were higher than those of the control group. The incidence of adverse reactions during bowel preparation in the intervention group was better than that in the control group. More patients in the intervention group were willing to undergo colonoscopy again than in the control group. The total satisfaction of the intervention group was higher than the control group. The differences were all statistically significant ( P<0.05) . Conclusions:Nursing intervention based on COX's IMCHB can improve medication compliance of outpatients undergoing colonoscopy, reduce the occurrence of adverse reactions such as nausea and abdominal distension and improve patients' medical experience and satisfaction.

Objective:To explore the effect of evidence-based management intervention on the self-management efficacy, quality of life and psychological status of patients with advanced colon cancer.Methods:From May 2017 to May 2019, convenience sampling was used to select 176 patients with advanced colon cancer admitted to the International Medical Department of Peking Union Medical College Hospital as the research object. According to the order of admission, the first 90 patients were included in the observation group, and the last 86 patients were included in the control group. Observation group carried out evidence-based management intervention, and control group implemented routine intervention. We compared the scores of the Strategies Used by People to Promote Health (SUPPH) , World Health Organization Quality of Life-BREF (WHOQOL-BREF) , Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) between two groups before and after intervention to evaluate the effect of evidence-based management intervention on self-management efficacy, quality of life and psychological status of patients.Results:Before intervention, there was no statistically significant difference in the scores of each dimension of the SUPPH between two groups ( P>0.05) . After intervention, the dimension scores of positive attitude, self-decompression, and self-decision in the SUPPH scale of observation group were higher than those of control group, and the differences were statistically significant ( t=4.423, 3.196, 3.148; P<0.01) . Before intervention, there was no statistically significant difference in scores of each field in WHOQOL-BREF between two groups ( P>0.05) . After intervention, the scores of physical, psychological, social relations and environmental fields of observation group were higher than those of control group, and the differences were statistically significant ( t=5.450, 6.458, 4.286, 2.104; P<0.05) . Before intervention, there was no statistically significant difference in the scores of HAMA and HAMD between two groups ( P>0.05) . After intervention, the HAMA and HAMD scores of observation group were lower than those of control group, and the differences were statistically significant ( t=10.171, 7.903; P<0.01) . Conclusions:The evidence-based management intervention can improve the self-efficacy of patients with advanced colon cancer, improve the quality of life of patients, and the psychological status of patients.

Objective:To explore the mediating role of self-efficacy between disease activity index and quality of life in patients with inflammatory bowel disease (IBD) .Methods:From January 2018 to March 2019, convenience sampling was used to select 173 IBD patients hospitalized in the Department of Gastroenterology of Peking Union Medical College Hospital as the research object. Patients were investigated with the Inflammatory Bowel Disease Questionnaire (IBDQ) , Chronic Disease Management Self-Efficacy Scale (CDM-SES) and the Disease Activity Index [Colitis Activity Index (CAI) /Crohn's Disease Activity Index (CDAI) ].We performed correlation and regression analysis on the data. The mediation effect test was carried out by using the test mediation effect procedure proposed by Wen Zhonglin.Results:IBD patients' disease activity index was negatively correlated with quality of life ( r=-0.466, P<0.01) , symptom management ( r=-0.156, P<0.05) ; quality of life was positively correlated with self-efficacy ( r=0.346, P<0.01) . Self-efficacy had a mediating effect between disease activity index and quality of life. Conclusions:The self-efficacy of patients with IBD plays a partially mediating role between disease activity index and quality of life. Nurses should pay attention to improving the self-efficacy of patients with active disease, thereby improving their quality of life.

Objective:To systematically evaluate the qualitative research on the psychological experience and coping of patients undergoing colonoscopy, so as to provide a basis for understanding the psychological status of patients undergoing colonoscopy and carrying out better psychological nursing.Methods:Chinese and English databases such as PubMed, Embase, Web of Science, CNKI, Wanfang Database and China Biology Medicine disc were searched by computer to collect qualitative studies related to the psychological experience of colonoscopy. The quality of the included studies was evaluated using Australian JBI Evidence-based Health Care Center Qualitative Research Quality Evaluation Standard (2016) , and the research results were integrated through a pooled integration method.Results:A total of 9 studies were included, 33 main results were extracted and summarized into 7 new categories, which were summarized into 3 integrated results, including psychological characteristics of patients undergoing colonoscopy, psychological needs of patients undergoing colonoscopy and coping styles of psychological changes of patients undergoing colonoscopy.Conclusions:Medical staff should pay attention to the psychological characteristics and psychological needs of patients undergoing colonoscopy during the examination, provide a variety of psychological support, improve satisfaction of patients undergoing colonoscopy and reduce the discomfort and negative emotions of patients.

OBJECTIVETo explore the clinical features, laboratory findings and treatment of infant leukemia.

METHODSA retrospective analysis of the clinical data was performed of the cases with the diagnosis of infant acute leukemia from August 1993 to October 2014 in our hospital.

RESULTSA total of 144 cases of infant leukemia were diagnosed in the defined period, including 83 cases of acute lymphoblastic leukemia, 55 myeloid leukemia, 1 hybrid acute leukaemia and 5 with incompatible cytological and immunophenotyping findings. The patients at the age of 9 to 12 months accounted for the largest proportion (38.2%), and 87.5% of the patients had hepatosplenomegaly; Six patients below 6 months old had skin infiltration. In about 1/3 of the patients, the white blood cells count was no greater than 100 × 10⁹ /L. Ninety-five patients had chromosome examinations, which identified chromosome abnormalities in 67 patients, including 18 positive for t(4;11)or t(9;11)or t(11;19), and younger patients were more likely to have chromosome abnormalities. Thirty-seven patients underwent MLL gene detection and 11 of them had positive results; the positive patients had higher rate of chromosome 11 abnormalities than the negative patients. Most of the patients gave up treatments after diagnosis and only 6 patients older than 6 months completed regular chemotherapeutic treatments and were now in complete remission.

CONCLUSIONInfant leukemia is a rare type of leukemia with different clinical features from other types of leukemia. The patients often present with hepatosplenomegaly, high white blood cell counts, MLL gene fusion, and chromosome 11 abnormalities. The prognosis of infant leukemia is not favorable, and the current treatment still relies on chemotherapy.

Acute Disease ; Chromosome Aberrations ; Chromosome Disorders ; Chromosomes, Human, Pair 11 ; Humans ; Immunophenotyping ; Infant ; Leukemia, Myeloid ; pathology ; Leukocyte Count ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; pathology ; Prognosis ; Retrospective Studies

The aim of the present study is to explore the association between abdominal obesity and chronic kidney disease (CKD) through a systematic review of published studies. Databases including Wanfang data, CNKI, VIP, CBM, Cochrane Library, PubMed, Web of science and Embase were searched up to July 2021 to collect longitudinal studies published in Chinese and English on the association between abdominal obesity and CKD. In order to avoid omission, reference lists of related articles were also checked manually. After literature selection, data were extracted and study quality was evaluated by the Newcastle-Ottawa scale. Statistical analysis of this study was conducted using Stata 11.0 software. Finally, five studies were included in this study. The results showed that abdominal obesity defined by waist circumference was not associated with CKD (OR=1.17,95% CI:0.93-1.48). According to the results of subgroup analyses, whether adjusted body mass index might be part of the reason of heterogeneity. Based on results of this study, the association between abdominal obesity defined by waist hip ratio and CKD, as well as the association between abdominal obesity and CKD in different genders, remains unknown. In conclusion, abdominal obesity might not be associated with incident CKD. However, more studies are needed in the future to explore this association.

Objective:To investigate the current situation with regard to a sense of coherence in major caregivers of enterostomy patients and analyze its relationship with self-efficacy and perceived social support.Methods:From July to December 2019, a total of 118 major caregivers of enterostomy patients were investigated using a general information questionnaire, a self-efficacy scale, and a perceived social support scale.Results:The score of sense of coherence in major caregivers of enterostomy patients was 58.40±9.17, and the average scores of all dimensions, from high to low, were “controllable sense，” “understandable sense，”and “meaningful sense.” Sense of coherence was positively correlated with self-efficacy and perceived social support ( r=0.457, P<0.01; r=0.369, P<0.01). Hierarchical multiple regression analysis showed that self-efficacy and perceived social support had a positive predictive effect on sense of coherence and explained 35.2% of the variance ( R′ 2=0.352, F=25.639, P<0.001). Conclusions:The main caregivers of enterostomy patients had a low level of sense of coherence. Self-efficacy and perceived social support have a positive effect on sense of coherence. Medical staff should take targeted measures to help caregivers improve their self-efficacy and social support system in order to improve their sense of coherence.