Fifty-six patients with abdominal wall endometriosis(AWE)were assigned into the proliferous group or the secretory group and the expression of estrogen receptor(ER)in the entopie,ectopic and normal endometrium was investigated.In the proliferous group,the positive ER expression rate on the entopie endometrium(85%)was significantly higher than that on the normal(60%)or ectopie endometrium (58%)(P<0.05).In the secretory group,the positive ER expression rate on the eetopie endometrium (57%)was significantly higher than that on the entopic (26%) or normal endometrium(25%)(P< 0.05).There was significant difference in the entopie and normal endometriilm between the two groups (P<0.01):however,there was no significant diffeFence in the ectopic endometrium.Abnormal ER expression on the entopic or ectopic endometrium may play a role in the pathogenesis of AWE.

The periovarian peritoneal cavity lacks a local barrier, and exosomes derived from body fluids such as follicular fluid and ascites are important non-cellular components in the tumor microenvironment of ovarian cancer. The contents carried by exosomes are highly similar to their source cells and become a new direction for studying the unique biological origin possessed by a variety of histological types of ovarian cancer. The article reviews the research progress of exosomes in the multiple origins of ovarian epithelial carcinoma.