1.DiPTAC: A degradation platform via directly targeting proteasome.
Yutong TU ; Qian YU ; Mengna LI ; Lixin GAO ; Jialuo MAO ; Jingkun MA ; Xiaowu DONG ; Jinxin CHE ; Chong ZHANG ; Linghui ZENG ; Huajian ZHU ; Jiaan SHAO ; Jingli HOU ; Liming HU ; Bingbing WAN ; Jia LI ; Yubo ZHOU ; Jiankang ZHANG
Acta Pharmaceutica Sinica B 2025;15(1):661-664
2.Development, reliability evaluation and validity of a health sevice experience assessment tool for patients with pulmonary tuberculosis
Jiajia YAO ; Yutong HAN ; Beibei CHE ; Danni LI ; Biao XU ; Qi ZHAO
Shanghai Journal of Preventive Medicine 2025;37(10):871-877
ObjectiveTo develop a scientifically rigorous and contextually appropriate instrument for evaluating the health service experience of pulmonary tuberculosis patients in China, to enable systematic assessment of core medical care dimensions, and to provide quantitative evidence for service improvement. MethodsGrounded in the theoretical framework of healthcare accessibility and the clinical care pathway for tuberculosis patients, the tool was developed through a systematic literature review and the Delphi expert consultation method. A multi-stage cluster sampling strategy was employed to survey pulmonary tuberculosis patients who had been receiving treatment for more than two months, aimed to explore the scale’s applicability in real-world settings. Reliability was assessed using Cronbach’s α and split-half reliability coefficients. Validity was evaluated through content validity, structural validity, convergent validity, and discriminant validity. ResultsThe tool was composed of 21 items across four dimensions: awareness, accessibility, affordability, and acceptability of tuberculosis medical care. It demonstrated a Cronbach’s α coefficient of 0.838 and a split-half reliability coefficient of 0.859. Exploratory factor analyses extracted six factors: satisfaction with healthcare services, supportive role of nurses, affordability of treatment costs, doctor-patient communication, waiting time for medical appointments, and transportation cost. The goodness-of-fit index (GFI) and other indices met the recommended standards, with the loading matrix indicating robust structural validity of the tool. The constructed factor model exhibited satisfactory content validity and discriminant validity. ConclusionThe scale for assessing patients’ experiences with tuberculosis-related medical care developed in this study demonstrates good reliability and validity and serves as a practical tool for evaluating patient experiences of tuberculosis medical care in China.
3.Nurses' knowledge-attitude-practice status on early enteral nutrition of critically ill patients in Class ⅢGrade A hospitals
Yin SU ; Jie LIU ; Yutong CHE ; Xue WU
Chinese Journal of Modern Nursing 2019;25(30):3963-3967
Objective? To explore the current status of nurses' knowledge, attitude and practice in Class Ⅲ Grade A hospitals on early enteral nutrition in critically ill patients. Methods? A total of 114 nurses in a Class Ⅲ Grade A hospital in Beijing were selected by convenience sampling method on March of 2019. Self-designed Nurses' Knowledge, Attitude and Practice Questionnaire on Early Enteral Nutrition in Critically Ill Patients was used to investigate the nurses,and the contents included their general information and their related knowledge, attitude, practice towards the critically ill patient's early enteral nutrition. Results? Nurses scored 5.00-85.00 points on Nurses' Knowledge Questionnaire on Early Enteral Nutrition in Critically Ill Patients, with a median of 35.00 points; Attitude Questionnaire scored 0.00-80.00 points, with a median of 80.00 points;Practice Questionnaire scored(51.49±13.18) points, ranging from 13.33 to 83.33 points; 27.19% of nurses had never received relevant knowledge training. Conclusions? Nurses should have comprehensive knowledge of early enteral nutrition for severely ill patient to enable patients receive more effective enteral nutrition support, pay attention to the clinical application of pyloric retroperitoneal feeding technology, integrate dynamic nutrition screening and intra-abdominal pressure measurement into routine nursing work, and find out the exist problems of early enteral nutrition in severely ill patients in time, improve the quality of holistic nursing, so that severely ill patients can get the most effective enteral nutrition support.

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