Objective To investigate the efficacy and safety of rescue stenting after failure of mechanical thrombectomy for acute cerebral large artery occlusive infarction. Methods A total of 29 patients with acute cerebral large artery occlusive infarction who failed mechanical recanalization, admitted to our hospital from January 2016 to March 2018, were chosen in our study; 18 patients accepted rescue stenting (stenting group) and 11 patients did not accept rescue stenting (non-stenting group). Comparative analyses of final vascular recanalization rate, complication rate, and clinical outcomes in the stenting and non-stenting groups were performed. Results The final recanalization rates of the stenting group and non-stenting group were 88.9％ (16/18) and 36.4％ (4/11), respectively, and the good prognosis rates were 55.6％ (10/18) and 18.2％ (2/11), respectively; the differences were statistically significant between the two groups (P<0.05). The incidence of symptomatic intracranial hemorrhage (11.1％ [2/18] vs. 18.2％ [2/11]) and mortality (22.2％ [4/18] vs. 45.5％ [5/11]) showed no significant differences among the two groups (P>0.05). Conclusion Rescue stenting after mechanical recanalization of acute cerebral large artery occlusive infarction can significantly improve the clinical prognosis without increasing risk of intracranial hemorrhage.