Objective:To assess type C behavior in patients with oral lichen planus (OLP) in order to provide basis for clinical prevention,treatment and psychological intervention of OLP.Methods:Type C behavior scale was used on 85 OLP patients and 85 control patients,who were in accordance with the inclusion criteria,in order to investigate their type C behavior.The scale included 9 items:anxiety,depression,anger,anger toward inside (anger-in),anger toward outside (anger-out),reasoning,domination,optimism,and social support.Scores of the 9 items between OLP patients and control group were calculated under the instruction of the scale and were statistically analyzed,and OLP group was further stratified statistically by sex,reticulate-erosive-ulcerative (REU) pathological type and course of diseases,and the scores of each group were analyzed and compared.Results:Among the 85 OLP patients,there were more females,more non-erosive lesion type,and the most common site for OLP was the buccal mucosa.The scores of the type-C behavior questionnaire for anxiety,depression,anger and optimism were respectively 43.01 ± 7.47,44.02 ± 7.61,21.56 ± 5.26,22.15 ± 4.00 among the OLP patients and were 37.94 ±8.70,39.58 ±7.35,18.12 ±5.39,24.05 ±3.23 among control group,with significant differences (P ＜ 0.05 for all) between the two groups.The female OLP patients had higher anxiety,depression,anger scores (43.21 ± 6.97,44.29 ± 7.54,21.64 ± 5.09) and lower reasoning,domination,optimism scores (39.12 ±5.66,16.29 ±3.95,22.05 ±4.12) with significant differences (P ＜0.05 for all) compared with those of the female controls.The scores between male patients and male controls showed no significant difference.The patients with erosive lesions had higher anger score (22.94 ± 5.26) than that of the patients without erosive lesions (20.60 ± 5.03),with a significant difference (P ＜ 0.05).With the development of the disease,the tendency of anxiety and depression of the patients were more obvious,while optimism scores remained declining.The patients suffering more than 3 years of OLP had higher anger-toward-outside scores (17.36 ± 3.35) than the patients suffering less than 3 years of OLP (15.19±3.99),with a significant difference (P ＜0.05).Conclusion:OLP patients showed an obvious type C behavior characteristic,especially in anxiety,depression,anger and low optimism.This research provides the C behavior characteristic of OLP for further psychological consultation or intervention during OLP treatment.

To investigate the effects of different fluid resuscitation on renal function and glycocalyx in septic shock rats. The septic shock SD rats (induced by lipopolysaccharide) were randomly divided into control group, normal saline resuscitation group, Lactate Ringer′s solution resuscitation group and succinyl gelatin resuscitation group ( n=6 each). The mean arterial pressure, heart rate, serum creatinine (Scr), urea nitrogen (BUN), renal blood flow, renal tissue pathology, serum interleukin-6, tumor necrosis factor α and glycocalyx were measured at baseline, the development of septic shock, 0 hour and 8 hours after resuscitation. When shock was established, the renal blood flow significantly decreased ( P<0.05) and recovered to normal at 0 hour and 8 hours after resuscitation. Compared with normal saline group and succinyl gelatin group, the levels of Scr, BUN and glycocalyx components (heparan sulfate, syndecan-1) were significant lower in Lactate Ringer′s solution group ( P<0.05). The pathology of kidney tissue suggested that the microscopic ischemic damage with Lactate Ringer′s solution were minor than the other two groups. Compared with normal saline and succinyl gelatin, Lactate Ringer′s solution can reduce the damage of renal function and glycocalyx in septic shock rats.

Objective To evaluate the changes in motor function impairment and brain functional networks of patients with acute ischemic stroke(AIS)through parameters of spontaneous activities of both upper limbs and electroencephalogram graph theory analysis methods.Methods The data of 34 acute ischemic stroke patients(observation group)with upper limb motor disorders who were treated in the Department of Neurology of the Affiliated Hospital of Southwest Medical University from January 2022 to October 2023,and 40 healthy controls(HC group)were collected.The subjects completed the National Institutes of Health Stroke Scale(NIHSS)and Fugl-Meyer Assessment(FMA)within 7 days,and wore wrist activity recorders(Actiwatch)continuously for 24 hours to collect data on sponta-neous activities of upper limbs and analyzed related parameters such as the coordination coefficient of both upper limbs(r),the activity ratio of the affected side to the healthy side upper limb(ULAR),etc.At the same time,all subjects completed approximately 2 hours of 19-channel electroencephalogram examination.After preprocessing the electroencephalogram data,5 segments of 10-second resting-state electroencephalogram were extracted for graph theory.Results ① Compared to healthy individuals,AIS patients exhibited decreased functional connectivity edges in the 8 and θ bands,with substantial reductions in network connections in the α band.In the β band,connections between the frontal,right parietal,and occipital regions weakened,while connections from the right temporal lobe to the left temporal lobe strengthened.In the γ band,there was a significant increase in connections throughout the brain.② Graph theory analysis revealed significantly increased shortest path lengths(α band:t=2.228,P＜0.05,d=-0.52;β band:t=-3.641,P＜0.01,d=-0.878)and decreased global efficiency(α band:t=2.535,P＜0.05,d=0.591;β band:t=3.321,P＜0.01,d=0.803)in the observation group compared to the control group.In the γ band,local effi-ciency(t=3.279,P＜0.01,d=0.765)and clustering coefficients were significantly higher(t=3.358,P＜0.01,d=0.783).③ In the-γ band,the ULAR ≤30％group showed significantly re-duced shortest path length(t=-2.063,P＜0.05,d=-0.802)and increased global efficiency(t=2.226,P＜0.05,d=0.865),local efficiency(t=2.95,P＜0.05,d=1.147),and cluste-ring coefficient(t=2.962,P＜0.05,d=1.148).④ In the observation group,the bilateral upper limb coordination coefficient during sleep was negatively correlated with NIHSS scores(r=-0.389,P＜0.05)and ULAR(r=-0.395,P＜0.05),while FMA scores were positively cor-related with ULAR(r=0.442,P＜0.05).Conclusion The parameters of spontaneous activities of the upper limbs can be used to determine the impairment of motor function in AIS patients.The combination of changes in brain functional networks and motor impairments can provide new ideas for the study of their neural network mechanisms.

Objective To evaluate the changes in motor function impairment and brain functional networks of patients with acute ischemic stroke(AIS)through parameters of spontaneous activities of both upper limbs and electroencephalogram graph theory analysis methods.Methods The data of 34 acute ischemic stroke patients(observation group)with upper limb motor disorders who were treated in the Department of Neurology of the Affiliated Hospital of Southwest Medical University from January 2022 to October 2023,and 40 healthy controls(HC group)were collected.The subjects completed the National Institutes of Health Stroke Scale(NIHSS)and Fugl-Meyer Assessment(FMA)within 7 days,and wore wrist activity recorders(Actiwatch)continuously for 24 hours to collect data on sponta-neous activities of upper limbs and analyzed related parameters such as the coordination coefficient of both upper limbs(r),the activity ratio of the affected side to the healthy side upper limb(ULAR),etc.At the same time,all subjects completed approximately 2 hours of 19-channel electroencephalogram examination.After preprocessing the electroencephalogram data,5 segments of 10-second resting-state electroencephalogram were extracted for graph theory.Results ① Compared to healthy individuals,AIS patients exhibited decreased functional connectivity edges in the 8 and θ bands,with substantial reductions in network connections in the α band.In the β band,connections between the frontal,right parietal,and occipital regions weakened,while connections from the right temporal lobe to the left temporal lobe strengthened.In the γ band,there was a significant increase in connections throughout the brain.② Graph theory analysis revealed significantly increased shortest path lengths(α band:t=2.228,P＜0.05,d=-0.52;β band:t=-3.641,P＜0.01,d=-0.878)and decreased global efficiency(α band:t=2.535,P＜0.05,d=0.591;β band:t=3.321,P＜0.01,d=0.803)in the observation group compared to the control group.In the γ band,local effi-ciency(t=3.279,P＜0.01,d=0.765)and clustering coefficients were significantly higher(t=3.358,P＜0.01,d=0.783).③ In the-γ band,the ULAR ≤30％group showed significantly re-duced shortest path length(t=-2.063,P＜0.05,d=-0.802)and increased global efficiency(t=2.226,P＜0.05,d=0.865),local efficiency(t=2.95,P＜0.05,d=1.147),and cluste-ring coefficient(t=2.962,P＜0.05,d=1.148).④ In the observation group,the bilateral upper limb coordination coefficient during sleep was negatively correlated with NIHSS scores(r=-0.389,P＜0.05)and ULAR(r=-0.395,P＜0.05),while FMA scores were positively cor-related with ULAR(r=0.442,P＜0.05).Conclusion The parameters of spontaneous activities of the upper limbs can be used to determine the impairment of motor function in AIS patients.The combination of changes in brain functional networks and motor impairments can provide new ideas for the study of their neural network mechanisms.