In the air flight, individuals rise rapidly to the environment of low-pressure hypoxia, low humidity and high noise. If we can't adapt to the change of the environment, we may suffer headache, stroke, epilepsy and other common nervous system diseases. With the increasing popularity of aviation, more and more in-flight medical emergencies are reported. Aviation medical is gradually concerned and studied by social people, medical internists and scientific research workers. This article will summarize the clinical characteristics and pathogenesis of common paroxysmal nervous system diseases in flight, and discuss the prospect of early warning and prevention of in-flight medical emergencies.

Objective Functional magnetic resonance imaging was used to explore the effects of oxcarbazepine on auditory cortex function in patients with epilepsy.Methods 21 patients with epilepsy treated with oxcarbazepine and twenty-one patients with epilepsy who matched age and gender but did not treat with oxcarbazepine were collected.Amplitude of low frequency fluctuation(ALFF)and re-gional homogeneity(ReHo)were used to compare the differences in the functional activity of the auditory cortex between the two groups.Results Compared with the patients without oxcarbazepine,the patients with oxcarbazepine had higher ALFF values in the right superior temporal gyrus,bilateral middle temporal gyrus and visual union cortex,and lower ALFF values in the bilateral orbitofrontal area and infe-rior temporal gyrus,the patients with oxcarbazepine had higher ReHo values in right superior temporal gyrus,bilateral middle temporal gy-rus,orbitofrontal area,and left visual union cortex,and lower ReHo values in bilateral superior temporal gyrus,inferior temporal gyrus and right middle temporal gyrus.In the same cross-sectional area,ALFF and ReHo values were enhanced in the right superior temporal gyrus,right cingulate gyrus,right somatosensory cortex and left visual union cortex,while ALFF and ReHo values were weakened in the bilateral inferior temporal gyrus.However,there was no significant difference in ALFF and ReHo values of bilateral transverse temporal gyrus and transverse temporal sulcus between the two groups.Conclusion Oxcarbazepine may affect auditory cortex function in patients with epilepsy,and it mainly acts on the secondary auditory cortex or regulates the excitatory balance of the auditory network.

Pregnant women account for 40% of all epilepsy patients, and the economic burden of pregnant women with epilepsy is 5 times higher than that of non-pregnant patients. Additionally, the rates of stillbirth and congenital malformations in pregnant women with epilepsy are 5 times greater than those in normal pregnant women. Therefore, it is crucial to comprehensively review and summarize the management of pregnant women with epilepsy to reduce the burden of the disease. This study provides a thorough review on teratogenic effects of anti-seizure medications (ASMs) used during pregnancy, and summarizes the effects of ASMs on health of offspring and offers clinical management recommendations for pregnant women with epilepsy, aiming to provide guidance for safe use of medications during pregnancy.