Objective To explore humidifying effects for artificial airway of mechanically ventilated patients by heat/moisture exchanger(HME) combined closed endotracheal suctioning(CS).Methods A total of 114 patients who had mechanical ventilation for at least 48h were randomly divided into two groups with 59 cases in experimental grooup and 55 cases in control group.HME combined CS were used in the experimental group,heated humidifier combined open endotracheal suctioning were used in the control group.The effect of humidification, the reserved time of artificial airway,the time on mechanical ventilation, the time of stay in ICU, the incidence of ventilator-associated pneumonia(VAP) and the mortality rate between the two groups were compared.Results Significant differences were found in the effect of humidification between the experimental group and the control group,more cases found insufficiency of humidification or excessive humidification and airway spasm in the control group, however,less time on mechanical ventilation and stay in ICU in the experimental group.The incidence of VAP in the control group was significantly higher than that in the experimental group.There were no significant differences existed in the reserved time of artificial airway and the mortality rate between the two groups.There were no accident of humidification occurred in the experimental group,while 8 cases complicated with choking with water in the control group.Condusion HME combined CS,used in mechanically ventilated patients ,could help to improve the effects of airway humidification and reduce the incidence of VAP,also shorten the duration of mechanical ventilation.

Objective To observe the effects of simvastatin o n the prognosis of patients with chronic heart failure with coronary heart diseas e.Methods During 2001-12~2003-12,114 cases were divided randomly into two groups:the treatment group(n=59),who received simvastatin 20mg QN,a nd the control group(n=55) .All patients with heart failure were treated by conventional therapy.Results Compared with the control group,the total cholesterol ( TC),LDL-C,C-RP of the patients in the treatment group were all degraded to dif ferent degrees and the LVEF was elevated obviously.The frequency of hospitaliza tion and the time were lower than that in the control group but were not signifi cantly different;the death rate was significantly lower than that in the control group(P

Objective To observe the efficacy of vitamin B2 combined with smecta in the treatment of infant diaper rash. Methods Fifty-nine infants were divided into the treatment group with 32 infants and the control group with 27 infants. The treatment group was given vitamin B2 combined with smecta treatment and the control group was given zinc oxide treatment. The efficacy was observed after 7 days of treatment. Results The remarkably effective rate of the treatment group was 87.5% and the total effective rate was 96.9%. The remarkably effective rate of the control group was 22.2% and the total effective rate was 66.7%. Statistical analysis showed that the two groups were significantly dif-ferent in the efficacy (P<0.01). Conclusion Vitamin B2 combined with smecta is a safe and reliable treatment scheme for infant diaper rash.

Mouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late embryogenesis. There are fundamental gaps in understanding how these diverse cell subtypes are generated. Here, by combining single-cell RNA-Seq with intersectional lineage analyses, we show that beginning at around E16.5, neocortical RGCs start to generate ASCL1