Objective To explore the association between body mass index(BMI)/waist circumference (WC)and blood triglyceride(TG)level in adults. To evaluate the value of the BMI and WC in diagnosing the hypertriglyceridemia by the receiver operating characteristic(ROC)curve.Methods A total of 1 093 adults(707men and 356 women)were examined in our hospital from July to September in 2008.Height,weight,WC and blood triglyceride were measured and analyzed.The ROC curve was drawn to evaluate the sensitivity and specificity of the threshold values.Results The hypertriglyceridemia rate was 33.5%among men and 8.3%among women.The BMI and WC of hypertriglyceridemia group were significantly higher than those of normal TG group for both men and women(P<0.01).The area under ROC curve was 0.728±0.041 for men and 0.708±0.021 for women when using BMI to predict hypertriglyceridemia.The optimal threshold value was 24.5 for men and 22.5 for women.The area under ROC curve was 0.790±0.042 for men and 0.714±0.020 for women when using WC to predict hypertriglyceridemia.The optimal threshold value was 86 cm for men and 77 cm for women.Conclusions Both BMI and WC are associated blood triglyceride level. WC and BMI are useful parameters in predicting hypertriglyceridemia.

Objective To identify novel ABO allele in Chinese population. Methods The ABO blood group was tested by serological method, and then genotyped by sequence-specific primer (PCR-SSP) , gene cloning and sequence analysis. Results A healthy blood dornor who was diagnosed as having A2 subgroup and A2O1genotype was subjected to ABO gene cloning and sequence analysis. The haplotype-specific sequence analysis indicate that two single-base deletions, where G-deletion at nucleotide position 261 and A-deletion at nucleotide position 496 were determined in the O1 allele. The nucleotide sequence of the novelO1 allele were identical to ABO 0101 allele except for A-deletion at nucleotide position 496 in exon7 of ABO locus. Conclusion We defined this 0 allele as a novel O1 variant allele, and its registered number by GenBank is AY374123.

Antigens, Neoplasm ; metabolism ; Antigens, Surface ; metabolism ; Colorectal Neoplasms ; immunology ; pathology ; Humans ; Prognosis ; Trophoblasts ; immunology

Objective:To investigate the diagnostic value of plaque type and nature of coronary artery angiography in patients with coronary heart disease.Methods:The clinical data of 80 patients with coronary heart disease in Hangzhou Red Cross Hospital were retrospectively analyzed.According to the CT value of plaque, 20 cases were classified into calcified plaque group (CT value ≥130 HU) and soft plaque group (CT value ≤60 HU). Mixed plaque group (CT value 60-130 HU) had 40 cases.The association between coronary stenosis and plaque type, platelet function, serum biochemical and adipocytokine indicators were compared among the three groups.Results:There was a certain correlation between the proportion of different types of plaque and the degree of stenosis.There were 12 cases of mild stenosis, 3 cases of moderate stenosis and 5 cases of severe stenosis in calcified plaque group, 11 cases of mild stenosis, 14 cases of moderate stenosis and 15 cases of severe stenosis in mixed plaque group, 2 cases of mild stenosis, 7 cases of moderate stenosis and 11 cases of severe stenosis in soft tissue plaque group, the difference was statistically significant (χ 2=13.27, P<0.05). Comparison of platelet function, the calcified plaque group, mixed plaque group and soft tissue plaque group had no statistically significant difference in platelet count (PLT) ( F=1.56, P>0.05). The PDGF-BB, TEG-MA and P-selectin levels in the soft tissue plaque group were higher than those in the mixed plaque group and the calcified plaque group, the differences were statistically significant ( F=11.57, 6.47, 18.74, all P<0.05). As to the adipose cytokines, the levels of CRP, IL-6, IL-12, leptin and SFRP5 in the soft tissue plaque group were higher than those in the mixed plaque group and the calcified plaque group, the differences were statistically significant( F=7.95, 21.31, 14.58, 9.37, 13.58, all P<0.05). Conclusion:Coronary CT angiography can evaluate the severity of coronary heart disease by evaluating the type of plaque, and provide a theoretical basis for clinical treatment.It is worthy of clinical promotion.

Objective:To investigate the expression of PDLIM3 in the ectopic and orthotopic endometrium of endometriosis(EMT)patients,as well as in healthy endometrium,and to explore its relationship with clinical signifi-cance.Methods:Bioinformatics analysis based on the Gene Expression Omnibus(GEO)database was conduc-ted,and a prospective cohort study was undertaken,involving 58 EMT patients treated at West China Second Hospital of Sichuan University and 27 patients with other benign gynecological diseases as the control group from December 2019 to July 2020.Ectopic and orthotopic endometrium samples were obtained from EMT patients,and normal control samples were obtained from patients with other benign gynecological diseases.Real-time quantita-tive polymerase chain reaction(qPCR),western blot,and immunohistochemistry were utilized to investigate PD-LIM3 expression in various tissue samples.Clinical parameters were analyzed to determine the correlation be-tween PDLIM3 and clinical features.Results:Compared to orthotopic endometrial tissues of EMT patients and normal endometrial tissues of control subjects,the mRNA(F =46.05,P<0.05)and protein(F =238.6,P<0.05)expression levels of PDLIM3 in ectopic endometrial lesions were significantly upregulated.The average optical density(AOD)of PDLIM3 protein obtained through immunohistochemical experiments in ectopic endometrial le-sions showed a positive correlation with the degree of dysmenorrhea(r =0.86,P<0.05)and CA 125 level(r = 0.41,P<0.05)in EMT patients.But no obvious correlation was found between the expression level of PDLIM3 and disease stage,menstrual volume,and CA199 level(P>0.05).Conclusions:The expression level of PDLIM3 in endometriosis lesions was significantly upregulated and correlated with the degree of dysmenorrhea and serum CA125 level.These findings suggest that PDLIM3 may play a significant role in the development and progression of endometriosis and could serve as a potential therapeutic target.

Epilepsy is a chronic neurological disease and a common disease in neurology.The epidemiologic characters,clinical characteristics and risk factors of epilepsy vary from region to region.Although there are relatively few studies on epilepsy in the plateau,current studies show that its morbidity and prevalence are higher than those in other regions.There is a large gap in epilepsy treatment in the plateau area,and the quality of life of patients is poor.Among them,cerebrovascular diseases,cerebral parasitic diseases and craniocerebral trauma are common causes of epilepsy in the plateau area.This paper summarizes the epidemiologic characteristics,clinical characteristics,risk factors,etiology,comorbidities and other related studies of epilepsy in plateau areas,aiming to offer valuable reference for the diagnosis and treatment of epilepsy patients in plateau areas.