Objective:To assess the value and impact of screening programme in mid-pregnancy women for the congenital fet abnormality that uses the two maternal serum markers:?-fetoprotein(AFP)and free?human chorionic gonadotrophin(free-?HCG) Methods:Serum screening of AFP and free-?HCG were offered to the 14～20 weeks pregnant Measuring the serum AFP and free ?HCGin pregnant women with ELISA,and combined with other factors:age,weeks of pregnancy,weight,etc.Measuring the high ri rate with special software.Results:Within 1 648 cases of women in the mid-pregnancy,Down's syndrom,18-trisomysyndrome an neural tube defect high risk rates in screen were 7.16%,0.61%and 2.37%respectively.1 case was confirm the Down's syndrome analysis of cytogenetics,another 2 cases was diagnosed neural tube defect via ultrasonography.Conclusion:the second trimester doub test would be effective and safe screening strategies and could be used to decrease natality of congenital fetal malformation

ve To explore the effectiveness of non-hazardous treatment of excreta on control of intestinal infectious diseases and parasitosis. Methods The popularization rate of sanitary latrines, the non-hazardous treatment rate of excreta, the prevalance rate of B-class intestinal infectious diseases and infectious rate of worm eggs were sta-tistically analyzed. Results With the increasing popularization rate of sanitary latrine and the non-hazardous treat-ment rate of excreta, the prevalance rates of 3 kinds of intestinal infectious diseases (dysentery, typhoid and hepatitis) decreased from 175.14/100 000 in 1991 to 57.78/100 000 in 2 000 namely decreased 67.01% . The infectious rates of helminth eggs decreased from 76.88% in 1991 to 22.16% in 2000 namely decreased 71.17%. Conclusion Non-hazardous treatment of excreta presented obvious effectiveness on disease prevention, which should be widely popularized in countryside.

In this article we review the relation between P2 purinoceptor subtypes and coronary heart disease (CHD).P2Y_1 ,P2Y_2 ,P2Y_(11) and P2X_7 receptors are related to inflammatory reaction in atheroselerosis plaque.P2X_3 receptor plays an important role in anginal nocuity response.P2X_4 receptor is involved in vascular remodeling and enhancement of myocardial contractility in non-infarct zone.P2Y2 and P2Y6 receptors are involved in resteno-sis.A polymorphism in P2Y_(11) receptors increase the risk of myocardial infarction.P2Y_1、P2Y_(12) and P2X_1 receptors play a role in thrombotic formation.The specific agonist and antagonist of P2 purinoceptor subtypes could be poten-tial targets for new drugs to treat CHD.

Objective To investigate the interference causes of indwelling gastric tube for patients undergoing laryngeal tumor surgery,and explore the appropriate clinical nursing countermeasures.Methods 60 cases of laryngeal cancer patients with indwelling gastric tube were divided into the control group and the observation group with 30 cases in each group.The control group used indwelling gastric tube with routine nursing,while in the observation group,the influencing factors for indwelling gastric tube were analyzed and per-tinent neasures were adopted timely.The satisfaction degree of patients,incidence of postoperative compli-cations,hospitalization time and effective rate of treatment were compared.Results The factors influ-encing use of indwelling gastric tube were tracheal extubation by patients,trachea cannula exodus,pipe blockage and postoperative complications.After timely expectant treatment and positive nursing,the nutri-tion intake and postoperative recovery were not affected.The related indexes of the observation group were better than those of the control group.Conclusions Patients after laryngeal cancer surgery need longtime indwelling gastric tube.Measures such as strengthening of education and propaganda,close observation of patients′ condition and timely expectant treatment should be given in order to ensure the normal use of gastric tube and reach desirable treatment effect.

Against the backdrop of ongoing healthcare system reform and escalating competitions among hospitals in China,more and more specialists and scholars on hospital administration begin to focus their studies on the theories and practice of hospital flows.Methodology frequently called into play in such study include out-patient flow refom,progressive flow improvement,and attention to management and service.Discussed in this paper are the advantages and disadvantages of these three methods as a reference for an appropriate choice by hospitals at large.

Objective:To observe the morphologic changes of cancer tissues and cells and clinical effect of microwave coagulation therapy (MCT) on oral squamous cell carcinoma.(OSCC), and then to evaluate the possibility of MCT in OSCC treatment.Methods:Forty OSCC patients were involved. MCT was adopted to the treatment of tumor primary focus, and associated with chemotherapy and lymphadenectomy of suprahyoid region or therapeutic neck dissection. After MCT the tissues were extracted for pathological examination immediately and morphologically observated by transmission electron microscope(TEM). All patients were received follow-up investigation for 3 years. The therapeutic effects of the two groups were observed and compared.Results:After MCT, the tissues of primary focus showed degenerative and necrotic tissue, inflammatory granulation, exudative necrosis, hyperplasia or atypical hyperplasia under light microscope. Apoptosis and mastocytes were observed besides the primary focus through TEM. Additionally MCT could protect oral faction, facies and improve survival quality and control local recurrence, which was more advanced than other old method (P

AIM: The quantitative determination of N,N-dimethylf in olgosaccharide was carried out. METHODS: Gas Chromatographic was employed. RESULTS: Experimental results showed that a good separation of DMF with other contents of sample was achieved on FFAP(50 m?0.32 mm) column,and the separation degree was more than 1.5.The linear range was 3.58～0.000358 mg/mL with r=0.999 9 and the relative standard deviation was 1.52%(n=5).and the limit of detection was 1.0 mg/mL.The recovery of the method was in the range of 95.7%～98.4%. CONCLUSION: The method is simple,rapid,accurate and precise.

【Objective】To observe the effect of electro-acupuncture(EA) and Banxia Xiexin Decoction(BXD) on motilin levels of functional dyspepsia(FD) rats.【Methods】 Sixty SD rats were randomized into normal control group,model group,mosapride citrate tablets(MCT,2.82 mg?kg-1?d-1) group,EA group,BXD(33g?kg-1?d-1) group,EA + BXD group.Except the normal control group,the rats with FD in other groups were induced by stimulating the rat tails with forceps clip. EA group received EA on bilateral acupoints of Zusanli(ST36) for consecutive 7 days.MTL content in rats plasma,antrum,jejunum,and hypothalamus was observed with radioimmunological method.【Results】MTL content decreased in the plasma,antrum,jejunum,and hypothalamus of the model group(P

Characterized by dihydropyrimidinuria, dihydropyrimidinase (DHP) deficiency refers to a rare disorder of pyrimidine degradation, with high phenotypic heterogeneity.The disease-causing gene is DPYS, and less than 40 cases were reported worldwide.Urinary gas chromatography/mass spectrometer (GC/MS) can screen clinically suspected patients, and gene sequencing is the main means of the diagnosis of the disease.This article reviews the pathogenesis, clinical manifestation, genotype and recent research progress of the disease.

Objective To study the effect of antipsychotic drugs combined with psychological intervention on the elderly patients with acute mental disorders after surgery operation.Methods 100 cases of elderly male patients undergoing surgery in our hospital from January 2015 to December 2016 as the object of study in the course of the study,were randomly divided into control group and experimental group,with 50 cases in each group.The control group received routine care,antipsychotic drug combined with psychological nursing intervention for patients in the experimental group,focusing on the psychological status of patients,strengthen exchanges and communication with patients,patients with heart to eliminate negative emotions,help patients recover as soon as possible.The anxiety and depression of the experimental group and the control group were compared and analyzed.Results After the corresponding nursing,the experimental group of patients with anxiety self rating scale and self rating Depression Scale score was significantly better than before nursing, the difference was statistically significant(P<0.05).The self rating depression scale of the experimental group was(44.23±3.78),and the self rating Anxiety Scale score was(42.35±5.98).In the control group,the depression score was(48.73±2.53),and the anxiety score was(45.94±4.92).The anxiety score and depression score of the experimental group were significantly better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Antipsychotic drugs combined with psychological intervention can help the elderly male surgical acute mental disorders recovered to a certain extent,ease the patients with depression and anxiety,with further clinical promotion and application significance.