In this article we review the relation between P2 purinoceptor subtypes and coronary heart disease (CHD).P2Y_1 ,P2Y_2 ,P2Y_(11) and P2X_7 receptors are related to inflammatory reaction in atheroselerosis plaque.P2X_3 receptor plays an important role in anginal nocuity response.P2X_4 receptor is involved in vascular remodeling and enhancement of myocardial contractility in non-infarct zone.P2Y2 and P2Y6 receptors are involved in resteno-sis.A polymorphism in P2Y_(11) receptors increase the risk of myocardial infarction.P2Y_1、P2Y_(12) and P2X_1 receptors play a role in thrombotic formation.The specific agonist and antagonist of P2 purinoceptor subtypes could be poten-tial targets for new drugs to treat CHD.

The effects of different iodide intakes on the thyroid sodium iodide symporter (NIS) mRNA expression, thyroid hormones, urinary iodine and tissue iodine in thyroid were observed. NIS mRNA expression was elevated; and urinary iodine, thyroid tissue iodine and thyroid hormones were significantly lowered in low iodine group. In high iodine group, NIS mRNA expression was inhibited and thyroid hormones decreased. The results show that NIS is the important component of this autoregulatory mechanism. Both low and high iodine intakes can lead to hypothyroidism.

With the increasing number of cancer patients, the aging population, the shortage of medical resources and other problems in China, the demand for palliative care is gradually increasing. However, nursing staff are the main implementors of palliative care, and their cognitive level of palliative care is closely related to the quality of palliative care service and the outcome of patients. By summarizing assessment tools of palliative care knowledge, attitudes and skills, this review aims to provide a reference for developing appropriate palliative care assessment tools for nursing staff in China.

Objective To explore the effects of the Calgary-Cambridge Guide training for practice nurses in promoting the nurse-patient relationship .Methods Totals of 52 practice nurses in our hospital from June 2012 to December 2012 were selected and randomly divided into the experimental group ( 25 cases ) and the control group (27 cases).Communication skills training based on the Calgary-Cambridge Guide was applied in the experimental group, while the general training materials were distributed in the control group .Nurse-patient relationship was assessed with the trust scale and the Calgary-Cambridge Guide Scale .Results After the training , the scores of respect, consistency, the authority of knowledge and technology , the sense of security and the confidence in the future of the experimental group were (3.65 ±0.45),(3.68 ±0.58),(3.62 ±0.51), (3.81 ±0.45) and (3.67 ±0.64), which were significantly higher than the scores before the training (t =-2.664,-2.712,-2.435,-3.429,-3.431, respectively;P<0.05).The scores of respect, consistency, the sense of security in the experimental group were significantly higher than those of the control group after the training ( t=2.560, 2.513, 2.231, respectively;P <0.05 ).The general score and the scores of eight dimensions of Calgary-Cambridge were significantly higher than those before (P<0.05).The general score and the scores of eight dimensions of Calgary-Cambridge of the experimental group were significantly higher than those of the control group (P<0.05).Conclusions The nurse-patient communication skills training based on the Calgary-Cambridge Guide can effectively improve the communication skills of practice nurses , and promote the nurse-patient relationship .

Objective:To explore the impact of intervention based on the SMG health management model on self-efficacy and medical coping styles of patients with moderate to severe stroke.Methods:In this experimental study, 106 stroke patients who visited the rehabilitation medicine department of the Second Affiliated Hospital of Xinjiang Medical University from April 2022 to August 2022 were selected by drawing lots and randomly divided into a control group (53 cases) and an intervention group (53 cases). The control group received routine health management after early stroke rehabilitation, while the intervention group was included in the SMG health management model intervention for 8 weeks based on the control group. The Medical Coping Style Questionnaire and Stroke Self-efficacy Questionnaire were used to compare the medical coping style and self-efficacy of the two groups and compared the results.Results:The total scores of coping style and self-efficacy in the intervention group were (16.42 ± 2.79) and (59.86 ± 13.84), which were higher than those in the control group (14.80 ± 1.70) and (35.96 ± 13.92) ( t = 3.50, 8.61, both P<0.05). The scores of avoidance and surrender coping styles were (13.28 ± 1.60) and (7.16 ± 2.10), which were lower than the control group′s (14.66 ± 0.77) and (8.26 ± 1.01) scores ( t = -5.48, -3.34, both P<0.05). Conclusions:Integrating the SMG health management model intervention into the early rehabilitation nursing process of patients with moderate to severe stroke can help improve patients′ self-efficacy, transform positive disease coping styles, actively cooperate with medical staff for rehabilitation training to improve disease prognosis.

Objective:To investigate the core competency and general self-efficacy status of geriatric nursing assistants in combination of medical treatment and endowment pension institutions and analyze their correlation.Methods:From December 2019 to February 2020, the convenient sampling method was used to select 300 geriatric nursing assistants from 15 combination of medical treatment and endowment pension institutions in Urumqi as the research objects. The general data questionnaire, Geriatric Nursing Assistants' Core Competence Questionnaire and General Self-efficacy Scale (GSES) were used to conduct the questionnaire survey. Pearson correlation analysis and multiple linear regression were used to analyze the relationship between them.Results:A total of 300 questionnaires were distributed and 292 were effectively received, with an effective recovery rate of 97.3%. The total score of core competency of 292 geriatric nursing assistants was (106.44±15.35) , and average score of each item was (3.94±0.57) , which were in the upper middle level. The total score of self-efficacy was (26.95±6.30) , which was in the middle level. Pearson correlation analysis showed that the total score of core competence and scores of various dimensions were positively correlated with the total score of GSES ( r=0.232-0.432, P<0.01) . Multiple linear regression analysis showed that general self-efficacy was the influencing factor of core competence of geriatric nursing assistants (standardized regression coefficient was 0.264, P<0.01) . Conclusions:Self-efficacy is an important influencing factor of core competence of geriatric nursing assistants. Improving the self-efficacy of geriatric nursing assistants can optimize their core competence and help development of the combination of medical and health care pension model.

Objective To discuss the use of the APP to continue nursing effect on the quality of life of children with cerebral palsy. Methods A total of 100 cases of cerebral palsy hospitalized in July to December of 2016 were selected as the observation group, and the continuation nursing based on"Xinjiang cerebral palsy mobile APP"was carried out. A total of 102 cases of cerebral palsy were used as the control group in the hospital in January to June of 2016, and the traditional continuation nursing was carried out, and the self-care ability and quality of life of the children were evaluated by Activity of Daily Living Scale (ADL), Pediatric Quality of Life Inventory TM3.0-Rheumatology (PedsQLTM3.0) on admission hospital, discharge and 6 months after discharge. Results The time, time and group interaction of 2 groups of children with cerebral palsy in ADL score were statistically significant (F=231.819, 33.382, P<0.01). The ADL score of 6 months after discharge in the observation group was (66.100 ± 7.368) points, the control group was (59.230 ± 10.534) points, and there was statistically significant (t=3.802, P<0.01). The time, group and time group interaction of 2 groups of children with cerebral palsy in PedsQLTM3.0 score were statistically significant (F=23.398, 234.374, 149.209, P<0.01). There was a statistically significant difference in the observation group between admission hospital and discharge, 6 months after discharge and discharge (t=-3.384,-4.198, P<0.05 or 0.01). The difference was statistically significant in control group between discharge and admission hospital(t =-17.809, P <0.01), but there was no significant difference between 6 months after discharge and discharge (P> 0.05). Conclusions Based on the continuation of"Xinjiang cerebral palsy mobile APP", nursing can improve the ability to care for children with cerebral palsy life, help children improve quality of life. Worthy of further promotion.

Objective:To establish the normal reference value of lumbar bone mineral density (BMD) under quantitative CT (QCT) in Chinese healthy adult females and to explore the regional differences.Methods:Total of 35 431 healthy women who met the inclusion criteria of Chinese health quantitative CT big data program were selected in this study. The BMD of the central plane of L 1 and L 2 vertebrae was measured by Mindways′s QCT system, and the mean value was taken. One-way analysis of variance was used to compare the BMD differences of lumbar vertebrae in women of different ages and regions. The subjects were grouped by an age interval of 10 years, and the level of BMD in different regions of the same age group were compaired. Results:The peak BMD of Chinese healthy adult women appeared in the age group of 20-29 years (Northeast China(183.01±24.58) mg/cm 3, North China (188.93±24.80) mg/cm 3, East China (187.54±27.71) mg/cm 3, South China (186.22±33.72) mg/cm 3, Central China (176.33±24.91) mg/cm 3, Southwest China(182.25±28.00) mg/cm 3), and then it decreased with age. The level of BMD in different regions decreased with the age. Before the age of 70 years, BMD in Central and Southwest China was always at a low level((176.23±24.91) to (90.38±28.12) mg/cm 3, 182.25±28.00 to (88.55±25.68) mg/cm 3), lower than those in Northeast China ((183.01±24.58) to (99.69±27.85) mg/cm 3), North China ((188.93±24.80) to (95.89±26.12) mg/cm 3), East China ((187.54±27.71) to (95.65±27.86) mg/cm 3). After 70 years of age, BMD tended to be the same in different regions ( P>0.05). The BMD values in Central China and Southwest China were similar in the age group of 40-60 years ( P>0.05). The BMD values in the health adult femles in the age group of 60 years in different regions of Chinawere all lower than those of bone mass abnormality (all P<0.05). The detection rate of osteoporosis in females over 50 years was the highest in Southwest China (25.65%) and it was the lowest in North China (17.30%). Conclusions:This study establishes reference values of BMD under QCT in healthy Chinese women, which can be used as a reference basis for identifying women with low BMD who are at risk of osteoporosis. The BMD value is the lowest in Southwest China and the highest in South China.