Mesenchymal stem cells (MSCs) derive mainly from the mesoderm pluripotent stem cells,with wide variety of sources,easily accessible,low immunogenicity,pluripotent,various damage repair,nutrition,and other features and functions.MSCs are widely used for clinical treatment of various diseases.In recent years,scholars deepens various physiological characteristics of MSCs,and the MSCs have been used in the treatment of retinal diseases.In this paper,the characteristics of the MSCs,such as immune markers,immunomodulatory properties,the role of nutrition and MSCs immune on diabetic retinopathy (DR),retinal degenerative diseases,choroidal neovascular (CNV),retinal ischemia-reperfusion immunomodulatory applications were reviewed.

ObjectiveTo explore clinical effect of hemabate combined with uterine massage in treatment of postnatal hemorrhage caused by uterine inertia. Methods120 patients with postpartum hemorrhage caused by uterine inertia were selected and randomly divided into the experimental group(60 cases)and the control group(60 cases).The experimental group was given hemabate combined with uterine massage treatment,with respect to only hemabate treatment in the control group. ResultsThe total effective rate of postpartum hemorrhage were 96.7 and 92% with significant difference(x2 = 15.396,P＜0.01)between the two groups. Conclusionhe treatment of hemabate combined with uterine massage was more effective than hemabate alone.It was particularly safe,effective,convenient to operate,quickly to get results and of great value for clinical promotion.

The peripheral T/NK cell lymphomas (PT/NKCLs) encompass a heterogeneous group of malignant lymphoid diseas-es, which derived from mature T-cells and NK cells. PT/NKCLs are rare, and its epidemiology and pathological subtypes showed signif-icant geographic and ethnic differences. PT/NKCLs, especially NK/T cell lymphoma (nasal type), are relatively common in Asian coun-tries. The use of an anthracycline-containing regimen is not associated with an improved outcome in most subtypes of PT/NKCLs, but is associated with an improved outcome in anaplastic large-cell lymphoma, ALK positive. High-dosage chemotherapy combined with stem cell transplantation is a considerable choice for newly diagnosed high-risk or refractory/relapsed PT/NKCLs because of its general-ly poor clinical outcome. Advances in new drugs have lagged behind DLBCL because of the disease rarity of PT/NKCL and biological heterogeneity. Nevertheless, new chemotherapeutic drugs, such as pralatrexate and bendamustine, and targeted drugs, such as alemtu-zumab, brentuximab vedotin, HDAC inhibitors, bortezomib, and lenalidomide, are recently emerging effective therapies in this area. We confidently believe that the era of PT/NKCLs is coming.

The paper discusses the reasons for the slow development of evidence-based pharmacy in hospitals, analyzes the necessi-ty and feasibility of evidence-based pharmacy services in medical college and university libraries.It also elaborates how to construct ef-fective and feasible evidence-based pharmacy service mode according to the advantages and characteristics of medical college and uni-versity libraries.

The annually American Society of Hematology (ASH) annual meeting is the biggest feast in this area.The 56th ASH annual meeting showed many important data related with lymphoma.Applied brentuximab vedotin as maintenance therapy after autologous stem cell transplantion,Hodgkin lymphoma (HL) patients acquired significant prolonged progression free survival (PFS).A phase Ⅰ study demonstrated that PD-1 inhibitor,nivolumab,has a high response in heavily treated HL,with ORR 87 ％,which has acquired the approval from FDA.BTK inhibitor,PI3K inhibitor,new CD20 antibodies,bcl-2 inhibitor and lenalidomide all are effective in relapsed or refractory chronic lympholytic leukemia (CLL) and non-Hodgkin' s lymphoma (NHL),but how to apply these new targeted drugs appropriately and combined with current chemotherapy regimens are quite difficult.CAR-T cells targeting CD19,CD20,CD30 or CD138 positive lymphomas are a kind of new cellular therapy,which has showed excellent efficacy.

Objective To explore the effect of mifepristone on the application of bleeding after abortion . Methods 64 cases of portal diagnostic case ,all of the artificial vaginal bleeding profusely not more than ten days ,B ultrasound examination of the uterine cavity was normal or low echo is less than 10mm ×10mm,were randomly divided into treatment group and control group ,each of 32 cases.The treatment group oral mifepristone 25mg,every day two times,and with oral roxithromycin ,motherwort capsule ,for five days .The control group oral roxithromycin ,motherwort Gongxuening Capsule and ,for five days.Results The treatment group after five days of vaginal bleeding need again clear palace number(1 cases)was less than that of the control group (12 cases),group of uterine bleeding quantity in-creased treatment in the course of treatment (0 cases) was significantly lower than that of the control group (5 cases). The treatment group again curettage rate (3.1%) was significantly lower than that of the control group (37.5%),the difference was statistically significant effect of the two groups (χ2 =11.68,P<0.05).Conclusion The efficacy of mifepristone in the treatment of bleeding after abortion ,reduced the incidence of Qing Dynasty palace again ,reduce the patient′s physical and psychological harm , but also to avoid the unnecessary disputes , is worth the clinical promotion.

Described in this paper are the subject service in foreign and domestic colleges and universities and its problems in domestic academic libraries,and multivariate subject service provided in Library of Guangdong Pharmaceu-tical University for the teachers and students in Guangdong Pharmaceutical University by embedding it into the study and research process of students according to the contents and requirements of readers' reference service and the distribution of information,in order to provide reference for subject service in domestic college and university libraries.

Objective:To assess the value and impact of screening programme in mid-pregnancy women for the congenital fet abnormality that uses the two maternal serum markers:?-fetoprotein(AFP)and free?human chorionic gonadotrophin(free-?HCG) Methods:Serum screening of AFP and free-?HCG were offered to the 14～20 weeks pregnant Measuring the serum AFP and free ?HCGin pregnant women with ELISA,and combined with other factors:age,weeks of pregnancy,weight,etc.Measuring the high ri rate with special software.Results:Within 1 648 cases of women in the mid-pregnancy,Down's syndrom,18-trisomysyndrome an neural tube defect high risk rates in screen were 7.16%,0.61%and 2.37%respectively.1 case was confirm the Down's syndrome analysis of cytogenetics,another 2 cases was diagnosed neural tube defect via ultrasonography.Conclusion:the second trimester doub test would be effective and safe screening strategies and could be used to decrease natality of congenital fetal malformation

Objective To explore the effects of herceptin on the serum tumor markers in patients with HER-2 positive advanced breast cancer treated with chemotherapy and its influence on the immune function.Methods Seventy-six patients with HER2-positive advanced breast cancer from January 2013 to June 2014 in Xiangyang No.1 People's Hospital Affiliated to Hubei University of Medicine were divided into the observation group (38 cases) and the control group (38 cases),fifty healthy subjects in the same period were selected as the blank group.The control group received gemcitabine combined with capecitabine,gemcitabine 1000 mg / m2 via intravenous infusion in the first and eighth day,capecitabine 2500 mg/m2 via intravenous drip from the first day to fourteenth day;the observation group were given trastuzumab on the basis of the control group,4 mg/kg for the first time,then 2 mg/kg,1 time/week,three weeks for a course,have been given for four courses.The peripheral blood lymphocyte subsets were detected by flow cytometry,the Carcinoembryonic antigen (CEA),cancer-associated glycoprotein antigen (CA153) and tissue polypeptide specific antigen (TPS) were detected by enzyme-linked immunoassay.The short-term efficacy,survival and adverse reactions incidence rate in the two groups were compared.Results (1) The clinical benefit rate of the observation group was higher than that of the control group (89.47% vs.63.15%,χ2=8.508,P<0.05),the 1-year survival rate of the observation group was 65.79%,the control group was 39.47%,the difference was statistically significant (χ2=5.278,P<0.05),the 2-year survival rate of the observation group was 42.11%,the control group was 21.05%,the difference was statistically significant (χ2=3.897,P<0.05).(2) The CD3+,CD4+ and CD4+/CD8+ of the observation group and the control group after treatment were (51.5±5.2)%,(52.7±4.4)%,(24.1±5.6)%,(26.7±5.0)%,(0.81±0.10),(0.86±0.13),respectively,which were lower than those collected before treatment (t=5.734,4.824,6.056,5.428,3.602,3.643,P<0.05)),there were no significant differences in lymphocyte subset between the observation group and the control group before and after treatment (P>0.05),the CD3+,CD4+,CD4+/CD8+ of the observation group and the control group after treatment were significantly lower than those of the blank group (F=14.484,9.371,8.213,P<0.01).(3) The CEA,CA153 and TPS of the observation group and the control group after treatment were (5.05±2.03) μg/L,(7.25±2.70)μg/L,(36.04±12.05) IU/ml,(55.42±18.23) IU/ml,(262.43±53.38) IU/ml,(355.21±47.80) IU/ml,which were significantly lower than those before treatment (t=8.743,3.805,7.929,5.271,9.512,6.389,P<0.05),the observation group was significantly lower than the control group (t=3.353、3.665、3.442,P<0.05).(4) The incidence rate of pain and fever in the observation group were 34.21% and 28.95%,respectively,which were significantly higher than those in the control group,the difference was statistically significant (χ2=15.683,12.862,P<0.01).Conclusion Trastuzumab can synergistically reduce the serum tumor marker content in the treatment of patients with HER 2-positive advanced breast cancer,effectively improve the short-term efficacy of conventional chemotherapy,extend the life span,without the cause of significant damage to the immune function,but it can significantly increase the incidence rate of pain and fever,so it is necessary to carry out targeted method to improve chemotherapy compliance.

In this article,the professor WANG Li-zhong’s experiences was described,which use the Lipi method to treat the cold,cough,dazzling dizziness,insomnia,stomach pain.Professor WANG Li-zhong Consider that the normal spleen and stomach’s ying and wei are harmonious,and there is no phlegm producted.When the functions of five zang viscera are coordinate,the vital qi is sufficiently and the pathogenic qi can’t injury to the body.Lipi method incarnates the professor WANG Li-zhong’s views to the dieases,its unique to treatment in clinic,and the academic thoughts of treating preventable diseases in Chinese medcine.