With the increase of Chinese people's material life level, their health consciousness has become more and more intense. Chinese Materia Medica, a treasure of Chinese medicine, has made a great contribution in maintaining people's health in the history. Patent is a kind of high-value scientific literature. In this paper, we retrieved the patents of the traditional medicines used in health care worldwide. The patents were further screened by a series of processes. Finally, multi-angle analysis was carried out on the dataset to form a patent analysis report of traditional medicines in health care, including the distribution of the patents, the application trends, the domestic and foreign geographical layout, the major applicant and its activity, the important technical areas, the important medicinal and its pharmacological properties and so on.

Schisandra is a frequent traditional Chinese medicine. It has the efficacy of SHOULIAN-GUSE, YIQING-SHENGJING, tonifying kidney and Ning heart, is very important tonic medicine. Patent literature records the majority of technological innovations, is a kind of valuable scientific literature, making good use of it can effectively promote innovation. And invention patent is the most valuable of all patent. Access to information found that there is no paper about analysis of schisandra related pantent in China. Thus, in this paper, Schisandra related patents were collected, statistics, analysis, to discover the information within, such as Schisandra patent history, the current pattern, outstanding invention agencies and drug law of Schisandra. Based on the result above, we hope to provide a reference for the patent application.

A . Senticosus is a common medicinal plants, mainly used parts are the dried roots, rhizomes and stems. Since ancient time, it has been regarded as one of top grade medicabecause of its safety and various medicinal properties. To further the development and utilization, a survey of patent information is very helpful to outline the current status of the drug. In this paper, Espacenetand World Traditional Medcine Patent Database were used to perform patent retrieval. Then the dataset were screened, standardized and analyzes via Python and R. The result indicates that, A . Senticosus, given being used for a long history, has less invention patents application comparing with other TCM drugs. The applications mainly come from China, Korea, Japan, Russia, and USA. The major functions includes systemic protection, anti-toxic agent, and treatments of nervous system, digestive system, metabolic, immune and allergic diseases. As to the compatibility of medicines, it often associated with tonic medicine, especially Buqi medicine.

Depression is a common mental disorders, severe cases may affect people's lives. In the treatment of de-pression, appropriate medication, as an assistant approach to psychological support, is proved helpful to patients' re-covery. Western medicine's ingredients are simple and mechanism is clear. Given it meets parts of the demand, the total effect is not satisfactory yet. Traditional Medicine's advantage is systematic, it has advantage in treating complex diseases. Thus, more and more attention was paid to Traditional Medicine, especially Traditional Chinese Medicine (TCM). In this paper, we use patent as data source to discover the law of the TCM's usage, the international differ-ences, the outstanding organization, and the hotspots of the drug research in the treatment of depression. Profiling of the current status can provide references in new drug finding and the progress of pharmacy. The results show that there are a few traditional Chinese medicine patents about treatment of depression associated with kidney, but de-pression and kidney also have a higher correlation. Medicines within soothing liver formulas such as Xiaoyaosan have many related patent.

Objective To determine whether the raised serum uric acid(UA)level is the independent risk factor for coronary artery disease(CAD).Methods A retrospective study was performed including 118 consecutive CAD patients(male 94,female 24)with average age of(65.79?10.03)and 67 normal angiography patients(male 43,female 24)with average age of(60.75?11.98).All the patients were performed coronary angiography from September 2003 to March 2004.In CAD group,36 cases were stable angina pectoris,28 were unstable angina and 54 were acute myocardial infarction.A fasting blood samples were collected for measurement of serum UA,blood cholesterol,and so on.And all patients were carefully inquired for their history including smoking and hypertension.Results Although raised serum UA was observed in CAD patients(372.31?100.28)mmol/L vs(340.08?81.58)mmol/L(P=0.028),logistic analysis suggested serum UA was not an independent risk factor for CAD.And there was no difference of UA among subgroups in CAD patients.Conclusion The raised serum UA may be a marker of atherosclerosis and is not an independent predictor for CAD.

In this paper, the patent of traditional medicines of type-2 diabetes mellitus before 2014 were searched, totally 1 229 patent family information were obtained. The patent information including developing trends, geographic distribution, competitive agencies, technical focus, herbs preferences and so on were analyzed. China is in a leader position on the number of applying patent of using traditional medicine to treat type-2 diabetes mellitus, and the main applications were research institutes, universities and pharmaceutical enterprises. Although the views and theo-ries on treatment of type-2 diabetes mellitus are variety and abound, the most frequently used traditional medicines are tonics and heat-clearing. This article reflected the history, clinical treatment way, developments, application of the diabetes traditional drugs after a meta-analysis,efforts to guide a better understanding and further research.

Objective To investigate the effect of the revision of Chinese Versions of Reading the Mind in the Eyes Test(RME) on the diagnosis of mild cognitive impairment (MCI) and mild Alzheimer's dementia (AD).Methods We compared performance on the cognitive test battery between 96 patients with MCI and 55 patients with AD and 95 control individuals.Neuropsychological tests, encompassing RME-T, Mini Mental State Examination (MMSE) and Auditory Verbal Learning Test (AVLT), were conducted on 96 patients with MCI, 55 patients with AD and 95 healthy control individuals.Completion rate of RME-T in the normal group and the total scores and each item score of RME-T were analyzed, and the feature between RME-T and RME-S (RME-short) was compared.Results The total score of RME-T was (23.7±4.7) in normal group, (19.9 ± 4.9) in MCI group,and (19.9±7.5) in AD group.There were significant differences in the total score of RME-T among the three groups (t=13.9, P＜0.01).The differences in the total score of RME-T between normal group and AD group, between normal group and MCI group were also significant (both P＜0.01).RME-S was composed of 20 items after rejecting 16 items of RME T whose project completion rate was lower than 50％ in the normal group and in which there was no significant difference among normal, MCI and AD groups.The correlations between the total score of RME-T and 3 item scores of RME-T were not significant (P＞0.05).However, the total score of RME-S was highly correlated with each item score of RME-S (P＜0.01).The total score of RME-T and RME S were highly correlated with each total score of the cognitive test battery (P＜0.01).With the normal and MCI groups, normal and AD groups as the subjects, the receiver operating characteristic (ROC) curve analysis found that AUC(RME-S) was＞ AUC(RME-T) in normal and AD groups (P＜0.01), whereas, AUC(RME-S) was＜AUC(RME-T) in normal and MCI groups (P＞0.05).Conclusions RME has good reliability and validity, and RME-S is better than RME-T in internal consistency, which is more suitable for identifying mild cognitive impairment and Alzheimer's disease in Chinese population, and it is worthy of further popularization and application.

Xi-Xin, a commonly used traditional Chinese herbal medicine, was regarded as one of the top grade materia medica since ancient time. The main medical parts were the root and stem. TheChinese Pharmacopeiaregulated the types ofAsarum heterotropoidesvar. mandshuricum,A. sieboldiivar. seoulense, andA. sieboldii. Analysis onXi-Xin related invention and patent information was an important aspect to understand the patent application condition and development tendency. It will also promote the research, development and industrialization of this medicine and promote its scientific result transformation. The Kongfz Patent Search Engine was used in the patent searching. Python and R languages were used in the collection, screening, classification, statistics, digging and analysis. In-depth analysis was made on the domesticXi-Xin related medical invention, patent application condition and development tendency. It provided references for the development ofXi-Xin. The results showed that an ever-increasing number of patents onXi-Xin were available. TheXi-Xin related inventions and patent applications were mainly from China, Republic of Korea, Japan, Russia, the U.S.A., etc. The main clinical applications were common cold, cough, headache, rheumatism and arthralgia, antibiosis, antiphlogosis, and cardiovascular diseases.Xi-Xin was mostly combined with herbal medicine with the effects of invigorating blood circulation and removing blood stasis, relieving exterior syndrome, and tonifying deficiency.

Ginkgo bilobaL. is one of the most common used medicinal plants worldwide. The mainly medicinal parts are dry leaf and dry seed. Root and stem also have medicinal value. It has been only found in the wild in Tianmu Mountain, Zhejiang Province, China, while cultivated in a much wider area. Since ginkgo is an important plant resources, a comprehensive overview is necessary, which can help understand the current status and the development trends. In this study, the patent information fromEspacenet and World Traditional Medicine Databaseis used to outline the technology development of ginkgo in the perspective of invention patents. The results showed that ginkgo development currently in the early or mid-term maturity period. Ginkgo got the best development in China. Most international exchange of intellectual property happened in United States. More attention has been paid to the development ofG. biloba leaf. Ginkgo’s medicinal application and compatibility were also analyzed in this study.

Patent documentation is a kind of high-value scientific literature. In this paper, the World Traditional Medicine Patent Database (WTMPD) was used to retrieve patents of the traditional medicines used in the treatment and prevention of alcoholic worldwide in the past 30 years. A total of 3 238 patents were further screened by a se-ries of processes. Finally, multi-angle analysis was carried on the dataset to form a patent analysis report on tradi-tional medicines used in alcoholism, including the distribution of the patents, the application trend, the domestic and foreign geographical layout, the major applicant and so on. From the analysis, we found that China had a rapid in-crease in the number of patent applications, which was in the leading role in the world, though the technology and the number of PCT applicant from China is relatively low. Puerariae Lobate radix and flos are frequently used in al-coholism patents.