Objective To study the diagnostic value of CDE in moyamoya disease.Methods The intra-and-extracranial arteries in 17 patients with moyamoya disease and 25 healthy volunteers were studies by CDE.The resistance index(RI),pulsatility index(PI),time-averaged flow velocity(Vm)were examined in arteries,including MCA、MCA、ACA、PCA、CCA、ICA、ECA and TSA.Results ①The diagnosis rate of the occlusion or stenosis in intracranial arteries was 87.25%.②The hemodynamic characteristics of CCA and ICA were high flow velocky and low resistance opposite to that of TSA.③The moyamoya vessels were seaned in 10 of all 17 patients with moyamoya disease by CDE.The diagnosis rate of moyamoya disease was 58.82%.Conclusions CDE technique could image the moyamoya vessels as scattered color dots. So CDE had a higher clinic value in diagnosis of moyamoya disease.

With the exploitation of marine resources and environmental deterioration, perilous events in the sea are gradually increasing. Seawater drowning is one of the most important causes of death. Researches on seawater drowning have attracted more and more interests in recent years, and certain progresses have been achieved in scientific research and clinical treatment. In the aspects of theory and establishment of a model, a renewed concept of seawater drowning-induced acute lung injury (SWD-ALI) has been acquired, the animal model of SWD-ALI has been successfully reprodaced for elucidation of the pathological and pathophysiological changes in lung tissue. Multiple results of molecular biological research on SWD-ALI have contributed to illuminating the pathogenesis involved. It is indicated that, compared with freshwater-induced lung injuries, SWD-ALI is severer in clinical picture, and it might develop to a peculiar seawater drowning-induced acute respiratory distress syndrome (SWD-ARDS) if no prompt and effective treatment is employed. For the clinical treatment for SWD-ALI, comprehensive therapies based on mechanical ventilation have been approved. The scientific outcomes mentioned above have laid a foundation for the full realization of SWD-ALI and more effective rescue of SWD-ALI patients.

Objective To observe the effect of partial liquid ventilation (PLV) and conventional mechanical ventilation(CMV) on gas exchange in lung injury due to pulmonary edema as a result of seawater drowning in rabbit. Methods Twenty-four healthy male new Zealand rabbits were randomly divided into three groups ( n =8). Pulmonary edema was produced in all rabbits by drowning in sea water. Rabbits of PE group received no treatment,that of CMV group were treated with conventional mechanical ventilation and PEEP,and that of PLV group with CMV,combined with PEEP and FDC. All rabbits were treated for 3 hours. Blood gases,TNF-?in plasma and pulmonary histopathology were determined during the experiment. Results In PLV group,PaO_2 was increased obviously,inflammatory exudate was reduced,and alveolar and interstitial edema was alleviated. The plasma level of TNF-?was significantly lower in PLA group compared with PE group,( P

Objective　To investigate regularity of intimal-medial　thickness（IMT）of extracoronary artery (including carotid, femoral and common iliac arteries ) in patients with coronary artery disease (CAD).Methods　Atherosclerosis of carotid, femoral and common iliac arteries was investigated with ultrasound in 115 subjects undergone coronary arteriography (CAG). Stepwise multiple regression analysis and Logistic regression were carried out between the results of extracoronary artery ultrasound examination and CAG.Results　The IMT and incidence of carotid, common iliac and femoral atherosclerostic plaques in patients with positive CAG were significantly higher than the subjects with negative CAG (P<0.01); Logistic regression indicated that the presence or absence of carotid, common iliac, femoral atherosclerosis was closely correlated with CAD (β were 2.147, 2.813 and 3.204 respectively,P<0.05,<0.01,<0.005 respectively. Odds ratio were 8.797,16.666 and 24.642 respectively,P<0.001). Stepwise multiple regression analysis showed that common iliac and femoral IMT were closely associated with LOG (1+Gensini′s score) (P<0.0001). For each increased 1 mm of common iliac and femoral IMT, the LOG (1+Gensini′s score) increased 0.20 and 0.19 respectively. Furthermore, the carotid artery IMT was also partly associated with LOG (1+Gensini′s score) (P<0.05). Common iliac atherosclerosis was closely correlated with occurrence of acute myocardial infarction,the positive predictive value of carotid, common iliac, femoral atherosclerosis was 75%, 87%, 88% respectively, the positive predictive values for 2 sites and 3 sites were 92%～98% and 100% respectively.Conclusions　The presence or absence and the extent and severity of coronary artery atherosclerosis can be predicted through investigating extracoronary artery atherosclerosis.Common iliac and femoral arteries can be asurrogate and window for studying the occurrence, progression of coronary artery atherosclerosis.

Objective: To observe the therapeutical effect of intermittent positive pressure ventilation (IPPV) on pulmonary edema after seawater drowning in rabbits.Methods:Fourteen seawater lavage induced pulmonary edema New Zealand rabbits models were assigned to receive IPPV treatment.Blood gas analysis, pulmodynamics, hemodynamics status and serum tumor necrosis factor(TNF ?) were monitored at various time points.After 3 h ventilation rabbits of each group were killed to gain lung tissues for pathology examination, and lung lavage fluid was analyzed to count leukocytes.Results:PaO 2 significantly increased after the use of ventilation in pulmonary edema rabbits models ( P

Currently, medical ultrasound teaching focuses on the delivering the image infor-mation itself, while its connection with basic medicine and clinical medicine is neglected. Such a teaching method is not good for students to establish a systemic view. To conduct the ultrasound medi-cine education effectively in undergraduate students, we have tried some reforms, including: perform-ing diseases or problem based teaching, integrating basic medicine, ultrasound medicine and clinical medicine throughout the whole teaching process, providing as many practice opportunities as possible for the graduates and integrating the ultrasound imaging with other medical imaging modalities. The practice shows that with the reform, the students have a better understanding of ultrasonic knowledge itself, a better grasp of the whole medical knowledge structure, and also have a preliminary impression on how to diagnose the disease through reasonable application of different treatments. In addition, students have more passion for study.

Objective To study regularity of atherosclerosic development and distribution in extracoronary arteries and its relation to risk factors in high risk group of atherosclerosis. Methods 　 Extracoronary atherosclerosis was investigated with ultrasound in subjects exposed to multiple cardiovascular diseases and undergone stepwise multiple regress analysis with cardiovascular risk factors. Results 　 Incidence of carotid, subclaviscular , abdominal aortic , femoral and common iliac artery atherosclerosis was 73%, 63%, 56%,54% and 51% respectively. The simple atherosclerostic plaque is the most common of three types(P<0.01); The incidence and IMT of femoral, abdominal aortic and iliac artery atherosclerosis were significantly higher in coronary artery disease (CAD) than those in the other groups(P<0.01);The incidence and IMT of carotid artery atherosclerosis in subjects with stroke were significantly higher than those in other groups;The age,systolic blood pressure and triglyceride were significantly associated with extracoronary atherosclerosis. Conclusion 　In descending order of incidence of extracoronary atherosclerosis,these were carotid,subclavicular,abdominal aortic,femoral and common iliac artery. The atherosclerosis of femoral,iliac and abodominal arteries was closely associated with CAD,and the atherosclerosis of carotid artery was significantly associated with stroke.

The aim of this study was to investigate the effect of fractioned radiation on the sensitivity of NCI-H446 small cell lung cancer cell line to chemotherapeutic drug and its mechanism. Exponentially growing NCI-H446 cells were exposed to 50 Gy radiation which was administered in 25 fractions with 2 Gy per fraction. The survival rate of NCI-H446 cell line was observed after the interference of different concentration of Mitomycin C given before and after fractioned radiation treatment. The survival rate of the radiated cells was higher than that of the unradiated cells with the same concentration of Mitomycin C(P

Objective To explore the difference of invovling rate in intracranial arteries and hemodynamics in extracranial arteries between child group and adult group moyamoya disease.Methods In order to differentiate the child and adult group moyamoya disease,the hemodynamic parameters such as pulse index(PI), resistance index(RI), mean velocity(Vm),systolic velocity/distolic velocity(S/D) were studied by ultrasound and the involving rate of intercranial arteries were studied by digital subtraction angiography.Results ① The involving rate of posterior cerebral artery(PCA) in child group was signifiicantly higher than that in adult group,but no difference in middle cerbral artery(MCA) and anterior cerebral artery(ACA); ② The mean flow velocity of vertebra artery(VA) were significantly reduced but RI,PI,S/D increased in child group than that in adult group moyamoya disease.No difference existed in other extracranial arteries.Conclusions The difference of extracranial arteries hemodynamics owes to the difference of intracranial artery involving rate.