One hundred and five patients with non-ST segment elevation acute coronary syndrome were followed up for 1 year.They were assigned to the event group or non-event group according to the presence of endpoint events(cardiac death and nonfatM myocardial infarction).B-type natriuretic peptide level was measured at 30 days and 1 year and compared between the two groups.The results showed that the level of B-type natriuretic peptide was higher in the event group[(235±107)μg/L vs(154±49)μg/L at 30 days;(259±100)μg/L vs(143±57)μg/L at 1 year].Thus,B-type natriuretic peptide is an important prognostic factor for patients with non-ST segment elevation acute coronary syndrome.

Objective To compare the effects of combined aerobic and resistance training(RT)versus aerobic training (AT) alone on glucose control and risk factors for complications in type 2 diabetic patients.Methods The database was retrieved from PubMed,EMBASE,the Cochrane Library and SportDicus.The randomized controlled trials (RCTs) of CT versus AT on type 2 diabetic patients were included.The data were analyzed with RevMan5.1.Results Six RCTs were included.The meta-analysis showed that compared with AT,CT improved glucose control,blood lipids,and decreased abdoninal fat.The difference of CT versus AT on blood pressure was not found.Conclusions The impact of CT on type 2 diabetic patients is better than AT.

ObjectiveTo investigate the relation between erectile dysfunction and myocardial infarction in recurrent myocardial infarction, sudden cardiac death and heart failure.Methods53 male patients with myocardial infarction were randomly divided into erectile dysfunction group and erectile normal group through International Index of Erectile Function-5(IIEF-5) subject test. Then the incidence of recurrent myocardial infarction, sudden cardiac death and heart failure were observed.ResultsThe incidence of recurrent myocardial infarction, sudden cardiac death and heart failure was higher in erectile dysfunction group than in erectile normal group.ConclusionThe prognosis of the patients with myocardial infarction following erectile dysfunction is unfavourable.

Objective To evaluate the relation between body exercise and physical function in elderly chronic obstructive pulmonary disease ( COPD) patients.Methods A total of 341 patients with COPD who were admitted into 3 comprehensive hospitals of Baoding city because of acute and severe occurrence were enrolled in this study.After stabilization of COPD, physical functional examination including the dyspnea status, nutrition state, lung function, the power of respiratory muscle, bronchi implantation and systemic inflammation response, was performed.Yale questionnaire was used to evaluate the physical function before admission.The correlation among those parameters was analyzed .Results The medium time of body exercise was 28.5h/w and the medium energy consumption was 5662 kcal/w.The differences in energy consumption with different sex, age, marital status, exercise, and smoking were statistically significant ( P<0.05).After regulating the confounding factors, body exercise was positively related to BMI, FEV1, FEV1/FVC, IC/TLC, RV/TLC, DLCO, Pimax, Pemax, 6MWD, VO2 peak, bronchi implantation, TNF-a and CRP (P<0.05). Conclusions Higher level regular exercise is related to better physical function in COPD patients .It prompt the underlying mechanism between body exercise and hospitalization rate and mortality , which is good for the development of target interventions .

Objective:To evaluate the relationship between B-cell lymphoma/adenovirus E1B19 kDa-interacting protein 3-like protein (BNIP3L)/adenovirus E1B-interacting protein and mitochondrial dysfunction in the hippocampus of mice with sepsis-associated encephalopathy (SAE).Methods:One hundred and eighty C57BL/6J mice, aged 6-8 weeks, weighing 20-25 g, were divided into 4 groups ( n=45 each) using a random number table method: control group (C group), sham operation group (Sham group), SAE group, and SAE+ BNIP3L agonist carfilzomib group (SC group). The sepsis model was developed by cecal ligation and puncture (CLP) in anesthetized animals. In SC group, carfilzomib 2 mg/kg was intraperitoneally injected at 2 h after CLP. Twenty mice in each group were selected, and the survival at 7 days after operation was recorded. Eight surviving mice in each group were selected at 1 week after CLP for Morris water maze test. The remaining mice were sacrificed at 24 h after surgery, and the hippocampal tissues were harvested for determination of the expression of BNIP3L (by immunofluorescence) and BNIP3L in mitochondrial protein (by Western blot) and for microscopic examination of the morphological structure of mitochondria. The mitochondrial ATP content was measured by fluorescein-fluorescence enzyme luminescence method, and the mitochondrial membrane potential (MMP) was measured by fluorescence spectrophotometry. Results:Compared with C and Sham groups, the survival rate was significantly decreased, the escape latency was prolonged, the time of staying at the original platform quadrant was shortened, and the number of crossing the original platform region was decreased, the expression of BNIP3L in the hippocampal mitochondria was down-regulated, the MMP and content of mitochondrial ATP were decreased ( P<0.05), the intensity of fluorescence of BNIP3L in the hippocampus was decreased, and the damage to mitochondrial ultrastructure was marked in SAE group. Compared with SAE group, the survival rate was significantly increased, the escape latency was shortened, the time of staying at the original platform quadrant was prolonged, and the number of crossing the original platform region was increased, the expression of BNIP3L in the hippocampal mitochondria was up-regulated, the MMP and content of mitochondrial ATP were increased ( P<0.05), the intensity of fluorescence of BNIP3L in the hippocampus was decreased, and the damage to mitochondrial ultrastructure was attenuated in SC group. Conclusions:BNIP3L-mediated mitochondrial dysfunction may be involved in the mechanism of SAE developed in mice.