Objective 　To evaluate the CT manifestation of pancreatic cancer. Methods 　The CT signs of 18 cases of pancreatic cancer which include 13 cases of pancreas caput cancer,3 cases of pancreas corpus cancer and 2 cases of panceras cauda cancer were studied and compared with 7 cases of duct ampulla cancer,5 cases of duodenal papilla cancer,4 cases of inferior choledochus duct cancer and 3 cases of inflammatic mass in pancreatic caput.All of cases have pathologic results.The study were performed with plain and contrast scan with PQ－2000 CT set and then the 3～5mm thin slice dynamic study were performed in the ROI.The artery phase and venous phases were studied. Results　The characteristic signs of pancreatic cancer includes： no enhancement of pancreas mass;pancreas atrophy inferior mass;enlargement of venous arch of pancreas caput and superior mesenteric artery;obscure retropancreas space and distance increasing between inferior choledochus duct and proximal pancreatic duct. Conclusion　It is valuable to diagnosis of pancreatic cancer with HRCT.

Objective To investigate the relation of pelvic three-dimensional conformal radiotherapy(3D-CRT) target with rectal dose distribution and irradiation volume in cervical cancer.Methods In 45 patients with cervical cancer(Ⅱa-Ⅲb) treated in our department from September to December 2006,we compared rectal dose distribution in different treatment plans: conventional radiation,4-field box radiation,4-field oblique radiation and 5-field radiation,and studied the relationship between rectal irradiation volume and dose in the target area.Results Compared with that of the other models,the dose distribution of CTV in 3D-CRT was relatively poor although it could satisfy the demand of treatment;dose distribution of D90,D80 and D50 in the radiated rectum differed significantly(P

Objective To review the diagnosis and treatment of basal cell carcinoma of the scrorum. Methods Clinical data of 7 patients with basal cell carcinoma of the scrotum were analyzed retrospectively. The mean age of the patients was 66 years. The most common presenting symptom was a plaque or nodular lesion with pruritis on the scrotum. The lesions ranged from 1.5 cm to 4.5 cm in diameter. Five of the 7 patients had a history of misdiagnosis. The diagnosis was established by biopsy of the lesion in all the patients. All of the 7 patients had no distant metastasis at the time of diagnosis and were treated by wide surgical resection.Results Histopathologic examination of the specimens confirmed the negative surgical margins in all cases.The most common histological feature was lobules, columns, bands and cords of basaloid cells associated with a surrounding loose fibromucinous stroma.One patient developed left inguinal lymph node metastasis at 21 months postoperatively,and was treated by bilateral inguinal lymph node dissection.The patient was free of cancer for 36 months after that. Another patient developed lung metastasis 48 months after the first operation.He was treated by systemic chemotherapy with cyclophosph amide, epirubicin and cisplatin for 6 cycles and obtained complete remission.This patient was free of cancer for 13 months after the chemotherapy.The remaining 5 patients were all free of cancer after the operation. Conclusions Basal cell carcinoma of the scrotum is rare.Wide surgical resection alone is usually considered to be curative. Because of its potential of metastasis, long-term followup is indicated for this disease.

Objective To study the expression of BCL10 and associated chromosomal aberration in primary cutaneous marginal zone B-cell lymphoma (PCMZL). Methods Tissue specimens were collected from 17 patients with PCMZL. Immunohistochemistry was used to detect the expression of BCL10. Fluorescence in situ hybridization (FISH) was performed to examine the presence of API2-MALT1 fusion gene and chromosomal aberration in BCL10, MALT1 as well as IgH genes in these cases. Results Of these patients,94.1% (16/17) expressed BCL10 protein. The cytoplasmic expression of BCL10 was observed in 64.7% (11/17) of the patients, and nuclear expression in 29.4% (5/17). As shown by FISH test, neither API2-MALT1 fusion gene nor chromosomal aberration in BCL10, MALT1 or IgH genes was present in these patients. Conclusions Compared with MALT lymphomas originating from tissues other than skin, PCMZL is uncommonly associated with chromosomal abnormalities; it is possible that there are unknown factors contributing to its tumorigenesis. Nuclear BCL10 is unrelated to the presence of chromosomal aberration in BCL10, MALT1 or IgH genes. Further follow-up is required to clarify the association between nucle ar BCL10 and poor prognosis of PCMZL.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly infectious and causes severe harm to human health. Almost everyone is susceptible to coronavirus disease 2019 (COVID-19). It is thought that COVID-19 is transmitted via droplets and close contact without protection. Aerosol propagation is possible in confined space. Preclinical patients and recessive infected people have certain infectivity, which increases the difficulty of prevention and control. Treatment for cancer patients needs to be continuous. Cancer patients on radiotherapy once a day need continuous treatment. Since a large number of patients come to the hospital for radiotherapy, medical staff need to contact them frequently. It is particularly important to absolutely avoid cross infection between tumor patients and medical staff. To this end, we have developed detailed management strategies, including establishing a core group, standardizing inpatient diagnosis and treatment processes, standardizing outpatient radiotherapy patient process, strengthening the ward and room disinfection, strengthening personnel management and other measures. We hope this paper provides reference for the department of tumor radiotherapy.

Objective: To analyze the clinical features and treatment of tracheal adenoid cystic carcinoma (TACC) so as to explore the therapeutic value of intensity-modulated radiotherapy in treating locally advanced inoperable tracheal bronchial adenoid cystic carcinoma. Methods: A patient with locally inoperable TACC was retrospectively reported with intensity-modulated radiotherapy, and the efficacy of interventional radiotherapy for locally inoperable TACC was analyzed. Results: After multi-course chemotherapy and radical radiotherapy, the patient was given intensity-modulated radiotherapy of DT46 GY/23F in the trachea and the bronchus and in the drainage area of mediastinal lymph node. Then the tumor area of the constricted trachea and the right main bronchus was given the radiotherapy up to DT60 GY/30F. The symptoms of shortness of breath and cough disappeared, and the tracheal and bronchial lesions were completely relieved. By combining with existing reports, single radiotherapy in locally advanced inoperable TACC can achieve survival of over one year and as long as 5 to 10 years in some patients. Results: Intensity-modulated radiotherapy has a positive significance in the treatment of locally advanced inoperable TACC.

Objective To explore the mechanism that PDEF inhibition the invasion and metastasis of prostate cancer cells by down-reg uLated HIF-1α. Methods PEDF and PBS as the experimental group and control group were add to the c uLture medium of human prostate cancer cell line (PC3), the wound healing and transwell experiment were carried out to observed the ability of invasion and metastasis. And HIF-1α expression was detect by RT-QPCR. ResuLts The res uLts of wound healing and transwell showed that PEDF inhibit the ability of invasion and metastasis of prostate cancer. PEDF down-reg uLated the expression of HIF-1α. Conclusions PEDF inhibit the invasion and metastasis of prostate cancer by down-reg uLated the expression of HIF-1α.It will be the new target of tumor intervention and for the treatment of prostate cancer and other malignant tumors to provide adequate scientific basis and efficient drug candidates.

Objective:To investigate the clinical efficacy of postoperative radiotherapy combined with compound matrine injection on the patients with breast cancer.Methods:Eighty-three patients with breast cancer received breast-conserving and sentinel lymph node biopsy before the study who were admitted in our hospital were divided into the control group and observation group.Forty-two patients in control group were treated with postoperative radiotherapy,and forty-one patients in observation group were received postoperative radiotherapy combined with compound matrine injection.The CA125,CA153,CA724,levels of CD3+,CD4+,CD8+,CD4+/CD8+,NK,and adverse reaction in the two groups were detected and compared.Results:After treatment,the CA125,CA153,and CA724 in both groups were obviously decreased (P＜0.05),which were significantly lower in the observation group than those of the control group (P＜0.05).CD3+,CD4+,CD8+,CD4+/CD8+,and NK cell in the observation group showed remarkable improvement (P＜0.05) compared with those before treatment.And CD3+,CD4+,CD4+/CD8+,and NK cell of the observation group were significantly higher than those of the control group,while CD8+ was much lower (P＜0.05).During the treatment period,the incidence of skin reaction over grade Ⅱ,and myelosuppression in observation group were much lower than those of control group (P＜0.05).Conclusion:Postoperative radiotherapy combined with compound matrine injection had good ability in enhancing the cellular immune function and reducing adverse reaction on the patients with breast cancer.

Objective: To observe the effects of electroacupuncture (EA) pretreatment on motor function, cerebral blood flow, cerebral infarction volume, and vascular endothelial growth factor (VEGF) level in middle cerebral artery occlusion (MCAO) model rats. Methods: Twenty-four male Sprague-Dawley rats were randomly divided into a normal group, a model group, and an EA group, with eight rats in each group. The middle cerebral artery ischemia-reperfusion model was established by the suture-occluded method in the model group and the EA group, while not in the normal group. The EA group was pretreated with EA at bilateral Fengchi (GB20) before model preparation, once a day for 30 min each time for a total of 7 d. The changes in the CatWalk gait parameters, modified Bederson neurological deficit score, cerebral blood flow, cerebral infarction volume after ischemia, and VEGF level in the brain tissue of rats in each group were observed. Results: Compared with the normal group, the modified Bederson neurological deficit score in the model group and the EA group increased after modeling (P<0.05), and the CatWalk gait parameters (one-leg stance duration, gait cadence, and gait cycle) were all changed (P<0.05). Compared with the model group, the modified Bederson neurological deficit score in the EA group decreased (P<0.05), and the CatWalk gait parameters improved (P<0.05). Immediately after ischemia, the cerebral blood flow in the normal group was greater than that in the model group and the EA group (P<0.05); after reperfusion, the cerebral blood flow in the EA group was greater than that in the model group (P<0.05). Compared with the normal group, the cerebral infarction volume in the model group and the EA group increased (P<0.05). Compared with the model group, the cerebral infarction volume in the EA group decreased (P<0.05). The expression level of VEGF-positive cells in the rat brain tissue in the model group was higher than that in the normal group (P<0.05), and was higher in the EA group than in the model group (P<0.05). Conclusion: EA pretreatment improves the limb motor function in MCAO model rats, alleviates the symptoms of neurological deficits, promotes the recovery of cerebral blood flow, reduces the cerebral infarction area after MCAO modeling, and increases the VEGF expression in the brain tissue.

Objective To investigate the correlation between the blood type IgG antibody valence and the hemolytic disease of newborn (HDN) of the pregnancy women with maternal-fetal ABO blood type incompatibility. Methods 2137 pregnant women with blood type incompatibility who delivered in the obstetrical department of our hospital from September 2011 to February 2014 and their neonates were selected as the study subjects. The last serum IgG antibody valence equal to or greater than 64 served as the clinical standard. After birth, the neonates' HDN related indicators were examined. The correlation between pregnant women's blood type IgG antibody valence and HDN and the risk factors were analyzed. Results Of the 2137 pregnant women with ABO blood type incompatibility, 458 perinatal infants had hemolysis. As the pregnant women's IgG antibody valence increased, the incidence of HDN rose significantly;Pearson correlation analysis showed that the correlation coefficient was r=0.82. Univariate analysis found that increase of number of pregnancies, increase of age, poor childbearing history and other factors were independent risk factors of HDN. Conclusion Before birth, blood type examination of couples and fetuses should be enhanced, IgG antibody de-tection of pregnant women with maternal-fetal ABO blood type incompatibility should be conducted, the pregnant women with advanced age, multiple pregnancies and adverse pregnancy history should be monitored closely, and proper intervention should be implemented in order to avoid the occurrence of HDN.