Objective To study the characteristics of invasive catheter infection in neurosurgery intensive care unit (NICU) to provide theoretical basis for the prevention of the infections.Method A retrospective analysis was done into the clinical data of 563 patients with indwelling catheter from January 2011 to December 2012 in our department.Results Among 563 cases undergoing invasive catheteration,there were 106 cases of catheter-associated infections with an incidence of 18.8%. The urinary catheter-associated infection was 24.5% and epidural drainage catheter-associated infection was 16.9%.Conclusion The enhanced consciousness of critical catheter infections,abiding by principles for aseptic operation and strengthened nursing to catheters or tubes are critical for reducing the incidence of invasive catheter-associated infections and ensuring the safety patients.