Objective: The development of individual subtypes based on biomarkers offers a cost-effective and timely avenue to comprehending individual differences pertaining to mental health, independent from individuals’ subjective insights. Incorporating 2-channel electroencephalography (EEG) and photoplethysmogram (PPG), we sought to establish a subtype classification system with clinical relevance. Methods: One hundred healthy participants and 99 patients with psychiatric disorders were recruited. Classification thresholds were determined using the EEG and PPG data from 2,278 individuals without mental disorders, serving to classify subtypes in our sample of 199 participants. Multivariate analysis of variance was applied to examine psychological distinctions among these subtypes. K-means clustering was employed to verify the classification system. Results: The distribution of subtypes differed between healthy participants and those with psychiatric disorders. Cognitive abilities were contingent upon brain subtypes, while mind subtypes exhibited significant differences in symptom severity, overall health, and cognitive stress. K-means clustering revealed that the results of our theory-based classification and data-driven classification are comparable. The synergistic assessment of both brain and mind subtypes was also explored. Conclusion Our subtype classification system offers a concise means to access individuals’ mental health. The utilization of EEG and PPG signals for subtype classification offers potential for the future of digital mental healthcare.

No abstract available.
Epidural Abscess* ; Meningitis, Bacterial*

Herpes simplex virus type 2 (HSV2) meningitis primarily develops during or following a primary genital HSV2 infection that was acquired from sexual contact or through the birth canal during delivery from mother. We describe a 15 year old virgin without history of previous herpes simplex infection who developed 2 episodes of HSV2 meningitis. Although recurrent meningitis due to HSV is primarily seen in young or sexually active adults. HSV2 meningitis should be in the differential diagnosis of recurrent meningitis in adolescent patients.
Adolescent* ; Adult ; Diagnosis, Differential ; Female ; Herpes Simplex ; Herpesvirus 2, Human ; Humans ; Meningitis* ; Mothers ; Parturition ; Simplexvirus*

BACKGROUND AND OBJECTIVES: The aim of this study was to define the clinical characteristics and treatment outcome of the salivary Warthin's tumor in order to work out a therapeutic strategy. SUBJECTS AND METHOD: The medical records of 64 patients who underwent surgery and were pathologically diagnosed with Warthin's tumor at our department from January 1997 to December 2009 were reviewed retrospectively. RESULTS: There were 60 (94%) males and 4 (6%) females with an overall male-to-female ratio of 15 : 1. The average age was 59.8+/-9.2 years (range from 35 to 78). All tumors were found in the parotid gland. Of the 66 tumors, 31 (48%) occurred in the right side, 28 (44%) tumors occurred in left side, and 5 (8%) tumors occurred in bilaterally. A superficial parotidectomy was performed in 38 (59%) patients, lumpectomy in 25 (39%) patients and bilateral lumpectomy in one patient. There were 18 (28%) postoperative complications. The most common complication was transient facial palsy that occurred in 11 (17%) patients. Recurrence occurred in 2 (3%) patients, oneipsilaterally and the other contralaterally. All recurrences were found in patients who underwent superficial parotidectomy. CONCLUSION: Warthin's tumor has a very low recurrence rate with a benign nature. The study shows that lumpectomy is an effective surgical treatment for Warthin's tumor with an advantage of reducing facial nerve palsy and recurrence rate.
Facial Nerve ; Facial Paralysis ; Female ; Humans ; Imidazoles ; Male ; Mastectomy, Segmental ; Medical Records ; Nitro Compounds ; Paralysis ; Parotid Gland ; Postoperative Complications ; Recurrence ; Salivary Glands ; Treatment Outcome

BACKGROUND AND OBJECTIVES: The aim of this study was to determine the efficacy of induction chemotherapy with docetaxel and platinum in patients with hypopharyngeal carcinoma. SUBJECTS AND METHOD: The medical records of 66 patients who were diagnosed with hypopharyngeal carcinoma at our department from January 1996 to December 2008 were reviewed and retrospectively analyzed. The patients were divided into four groups according to treatment method: Group I was treated with radiation and induction chemotherapy consist of docetaxel and platinum (27); Group II was treated with surgery and induction chemotherapy consist of docetaxel and platinum (28), Group III was treated with radiation and induction chemotherapy consist of 5-FU and platinum (9) and Group IV was treated with surgery and induction chemotherapy consist of 5-FU and platinum (2). A total of 186 chemotherapy cycles were administered to patients and most of the patients received at least 2 cycles. RESULTS: The T-stage distribution at diagnosis was 7.5%, 42.4%, 28.8%, and 21.2% for T1, T2, T3, and T4, respectively. The N-stage distribution at diagnosis was 48.5%, 22.7%, 10.6%, 15.2%, and 9.1% for N0, N1, N2a, N2b, and N2c, respectively. The overall 3-year survival rate was 44.3%. The 3-year survival rate of each group was 42.6% in Group I, 54.8% in Group II, and 11.1% in Group III. There was no significant difference in survival between Groups I and III (p=0.074). There was no difference in sex, age, and N stage for 3-year survival rate. CONCLUSION: Although any valid conclusions could not be drawn because of the small number of patients examined here, induction chemotherapy consisting of docetaxel and platinum may improve the outcome of patients with hypopharyngeal carcinoma.
Fluorouracil ; Humans ; Induction Chemotherapy ; Medical Records ; Platinum ; Retrospective Studies ; Survival Rate ; Taxoids ; Treatment Outcome