1.Research progress in the correlation between SREBP/PCSK9 pathway and lipid metabolism disorders induced by antipsychotics
Jiashu MA ; Yunshao ZHENG ; Fengxia SUN ; Yunli FAN ; Yunming FAN ; Xianbiao SU ; Zhongbao WANG ; Ning WENG ; Ranran LI
Journal of Central South University(Medical Sciences) 2023;48(10):1529-1538
Antipsychotic medications are commonly used to treat schizophrenia,but they can have negative effects on lipid metabolism,leading to an increased risk of cardiovascular diseases,reduced life expectancy,and difficulties with treatment adherence.The specific mechanisms by which antipsychotics disrupt lipid metabolism are not well understood.Sterol regulatory element-binding proteins(SREBPs)are important transcriptional factors that regulate lipid metabolism.Proprotein convertase subtilisin/kexin type 9(PCSK9),a gene regulated by SREBPs,plays a critical role in controlling levels of low-density lipoprotein cholesterol(LDL-C)and has become a focus of research on lipid-lowering drugs.Recent studies have shown that antipsychotic drugs can affect lipid metabolism through the SREBP/PCSK9 pathway.A deep understanding of the mechanism for this pathway in antipsychotic drug-related metabolic abnormalities will promote the prevention of lipid metabolism disorders in patients with schizophrenia and the development and application of new drugs.
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