OBJECTIVETo study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.

METHODSThirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.

RESULTSThe activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).

CONCLUSIONA certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.

Animals ; Female ; Formaldehyde ; toxicity ; Gastric Lavage ; Lipid Peroxidation ; Liver ; drug effects ; metabolism ; pathology ; Male ; Malondialdehyde ; metabolism ; Mice ; Mice, Inbred ICR ; Superoxide Dismutase ; metabolism

Long distance running is a popular sport with a high risk of getting musculoskeletal injuries, which is closely related to running shoes and foot-strike patterns. Biomechanical researches on relationship of running shoes and foot-strike patterns with running injuries were searched on the chain cloud library and Google academic database, and a total of 42 papers published from 1981 to 2016 were reviewed. There is not enough evidence to prove that running shoes have an effective cushioning and motor controlling function as what they claim, while barefoot running as a kind of more natural running pattern should be encouraged. Generally speaking, the forefoot strike has a lower injury risk on the knee, but increases the load on ankle and metatarsal bones. On the contrary, the rear foot strike always has a higher injury risk on the knee while a lower load on ankle and metatarsal bones. Therefore, runners should choose a suitable running method depending on their own conditions. The influence of running method transformation on biomechanical characteristics of lower limbs is not clear, and researches in such area may give more effective suggestions for runners to change their running methods.

Animals ; SARS-CoV-2 ; Antibodies, Neutralizing ; Macaca mulatta ; COVID-19/prevention & control* ; Antibodies, Viral ; Vaccines