Severe acute pancreatitis (SAP)is a special type of acute pancreatitis,and misdiagnosis and mistreatment can easily cause seri-ous complications,which makes it a tough disease in clinical practice.In recent years,integrated traditional Chinese and Western medicine therapy for SAP has been explored and great progress has been achieved with several new highlights.It has special advantages in clinical treatment.However,conventional methods are still used for the treatment of SAP,and a lack of treatment classification and literature review limits its efficiency and quality in clinical treatment.This article summarizes the effective treatment modalities for SAP from the perspectives of Western medicine and traditional Chinese medicine,in order to provide a reference for the development in the clinical treatment of SAP.

ObjectiveTo study the influence of preoperative transcatheter arterial chemoembolization (TACE) on liver resection in patients with resectable hepatocellular carcinoma (HCC).MethodsTACE was performed before liver resection in 62 out of 126 patients, and perioperative risk factors were compared with that of the 64 patients without TACE including liver perioperative function alterations, average blood loss during operation, the average time of clamping porta hepatis and operation, abdominal drainage at 1-, 2-, and 3-days post-op, mortality and morbidity. ResultsThere was not significant difference in liver function alteration in the two groups, there was no mortality in the two groups. Liver cirrhosis in TACE group was more serious than that in no TACE group, the operation time was longer in TACE group. Blood loss, and abdominal drainage were much more in TACE group than in no TACE group. However postoperative complications did not differ.Conclusion Preoperative TACE for resectable HCC increases surgical difficulty and risk. Preoperative TACE for resectable HCC needs to be used on baseis of strict selection.

Objective: To study the influence of preoperative transcatheter arterial chemoembolization (TACE) by selection on survival rate of resectable hepatocellular carcinoma (HCC) patients. Methods: Jan. 1996 to Jan. 1997, TACE was performed before surgery in 62 of 126 patients undergoing resection and the other 64 patients without TACE from. Results were retrospectively analyzed with regard to the changes of pathological examination after operation, recurrence rate and survival rate 1, 2, 3 years after operation. Results: Pathological examination showed that there were 13 total necrosis in TACE group, but no one in contrast group. There were no significant difference of recurrence rate 1, 3 years after operation between 2 groups. Recurrence rate 2 years after operation was 29.8% in TACE group, but 58.3% in contrast group. There were significant difference of recurrence rate 2 years after operation between 2 groups (P<0.05). Survival rate 3 years after operation was 54.4% in TACE group, but 33.3% in contrast group. Survival rate of TACE group was higher than that of contrast group (P<0.05). There were not significant difference of recurrence rate 1, 2 years after operation between 2 groups. Conclusion: Proper preoperative TACE for resectable HCC can improve the outcome of the operation to some extent.

Research on disease-syndrome combination is the main approach and method of research on integrative traditional Chinese and Western medicine. Disease-syndrome combination embodies the complementary advantages of traditional Chinese medicine and Western medicine. It discusses the relationship between diseases and syndromes through an interdisciplinary approach, and explores rules of disease diagnosis and treatment based on differential diagnosis. Thanks to the development of modern life science techniques, research on disease-syndrome combination has made great achievements. This article mainly introduced the application and the development prospects of new techniques, such as data mining, system biology, epigenetics, biological network and network pharmacology in the research on disease-syndrome combination in recent years, with a purpose to provide the ideas and the methods for further research and clinical application.

Objective : To investigate the effect of palmitoleic acid (POA) on pyroptosis of cardiomyocytes after hypoxia/reoxygenation⁃induced injury in the human myocardium . Methods : The experiment comprised a control group (Control , normal culture) , a hypoxia/reoxygenation group (HR) , a palmitoleic acid⁃treated group ( HR + POA) , and an anhydrous ethanol control group ( HR + ET) . Cardiomyocytes viability was assessed using CCK⁃8 assay , and the level of pyroptosis of cardiomyocytes was measured through the double staining with Hoechst33342/ PI and LDH assay . ELISA was employed to detect the release of inflammatory factors IL⁃1β and IL⁃18 in the cell culture supernatant . qRT⁃PCR and Western blot were utilized to determine the relative expression levels of mRNA and protein of pyroptosis⁃related genes , namely NLRP3 , ASC , Caspase⁃1 , GSDMD , IL⁃1β and IL⁃18 , respectively . Results : CCK⁃8 assay showed that the survival of hypoxic/reoxygenated cardiomyocytes increased with the addition of POA at concentrations ranging from 25 to 100 μmol/L , as compared to the HR group ; a hypoxia/reoxy⁃genation model of cardiomyocyte was established . The expression of protein and mRNA increased in NLRP3 , ASC ,Cleaved caspase⁃1 , GSDMD⁃N , IL⁃Iβ and IL⁃ 18 vs the control group(P < 0. 05) , the positive percentage of Hoechst33342/PI staining in cardiomyocytes increased significantly (P < 0. 05) , the release of LDH , IL⁃Iβ , and IL⁃18 increased (P < 0. 05) . After intervention with 100 μmol/L POA , the protein and mRNA expression levels of NLRP3 , ASC , Cleaved caspase⁃1 , GSDMD⁃N , IL⁃Iβ , and IL⁃18 were significantly reduced in the HR + POA group vs HR + ET group( P < 0. 05) . The positive percentage of Hoechst33342/PI staining in cardiomyocytes decreased significantly , and the levels of LDH , IL⁃Iβ and IL⁃18 significantly decreased (P < 0. 05) . Conclusion Palmitoleic acid may alleviate hypoxia/reoxygenation⁃induced injury of cardiomyocytes by inhibiting pyroptosis and inflammatory response after hypoxia/reoxygenation in human myocardium .