1. Assessing the consistency of methods to measure travel behavior related to exposure to air pollution
Na LI ; Zhe LIU ; Yunpu LI ; Ning LI ; Qin WANG ; Yaxi WU ; Yibing YANG ; Chunyu XU ; Dongqun XU
Chinese Journal of Preventive Medicine 2018;52(6):608-614
Objective:
To compare diary-reported trips and Global Positioning System (GPS) recording trips and identify the reasons for the discrepancies between two methods.
Methods:
The survey was conducted in Jiangning district in Nanjing city during July to September and November to December, 2015. Both the diary records and GPS method were used to investigate the travel behavior of 33 retired adults for 5 consecutive days. The GPS traces were display in Google Earth and then split into trips to compare with the diary records according to time and location. χ2 test was used to analyze the influence of trip characteristics on misreporting rates of each method.
Results:
A total of 1 087 trips in the survey can be compared between the diary (
2.Qianjin Weijingtang in Treatment of Chronic Obstructive Pulmonary Disease: A Review
Xin PENG ; Yun WANG ; Yunpu QIN ; Yunfan WANG ; Jihong FENG
Chinese Journal of Experimental Traditional Medical Formulae 2023;29(23):189-196
Chronic obstructive pulmonary disease (COPD) is a chronic heterogeneous airway disease characterized by persistent and progressive airflow restriction, which can be divided into stable COPD and acute exacerbations of COPD (AECOPD). Its morbidity and mortality remain high, posing a serious threat to human health. Traditional Chinese Medicine (TCM) believes that COPD belongs to the categories of "cough", "dyspnea syndrome", "lung distension", etc. And its basic pathogenesis is intermingled phlegm and stasis with deficiency in origin and excess in superficiality. Qianjin Weijingtang, derived from the Records of Proved Prescriptions, Ancient and Modern (古今录验方), consists of Phragmitis Caulis, Persicae Semen, Coicis Semen, and Benincasae Semen, with remarkable functions in clearing the lung, resolving phlegm and eliminating blood stasis, and has definite clinical efficacy in treating COPD and its syndromes. At present, in clinical studies, Qianjin Weijingtang has been used to treat COPD with modifications. It can be used alone or in combination with other prescriptions/western medicines to treat stable COPD, AECOPD, COPD complications, and other TCM syndromes of COPD such as phlegm-heat-stagnation obstructing the lung syndrome. It can significantly improve clinical symptoms, lung function, and blood gas indexes, and inhibit inflammatory response. Animal experiments mainly explored the mechanism of COPD from the level of pathological changes. Specifically, the underlying mechanism may be related to regulating T helper 17 (Th17)/regulatory T cells (Treg) balance, up-regulating single immunoglobulin IL-1-related receptor (SIGIRR) for resisting inflammation, up-regulating hyperplasia suppressor gene (HSG) and inhibiting Wnt signaling pathway activation to inhibit airway remodeling. It was found that there were many problems, such as low quality of clinical research, failure in sharing research standards, and the lack of mechanism research. This article systematically reviewed clinical studies of Qianjin Weijingtang in the treatment of COPD and its mechanism based on animal experiments in recent years, and put forward thoughts and suggestions according to the existing problems to provide references for the clinical application and further research on Qianjin Weijingtang.
3. Effect of ambient fine particulate matters exposure on nasal oxidative stress level in patients with allergic rhinitis in Taiyuan city
Yibing YANG ; Xin LI ; Qin WANG ; Liu LIU ; Chunyu XU ; Zhe LIU ; Na LI ; Feng HAN ; Yunpu LI ; Dongqun XU
Chinese Journal of Preventive Medicine 2019;53(1):64-70
Objective:
To explore the effect of ambient fine particulate matters (PM2.5) exposure on nasal oxidative stress level in patients with allergic rhinitis (AR).
Methods:
A panel of sixty AR patients was recruited as subjects. Four repeated measurements were carried out from June 2017 to January 2018. Nasal irrigation solution was collected and examined for malondialdehyde (MDA) and superoxide dismutase (SOD). Monitoring data of atmospheric pollutants and meteorological factors during measurement periods were also collected. Time activity pattern combined with micro-environment monitoring method was used to evaluate PM2.5 exposure. Mixed effect model was applied to analyze the relationship between PM2.5 exposure concentration and oxidative stress level.
Results:
49 subjects accomplished the four repeated measurements, and the mean±