Objective:To explore the value of fractional exhaled nitric oxide(FeNO)in the diagnosis of bronchial asthma and chronic obstructive pulmonary disease(COPD).Methods:A hundred and twenty patients with COPD,120 patients with asthma and 120 healthy volunteers were enrolled in this study.FeNO value was compared among the three groups.Results:FeNO value in patients with COPD,patients with asthma,healthy volunteers were (25.8± 15.6)ppb,(64.1 ±51.8)ppb,(18.8± 7.3)ppb,respectively.There was significant differences between the patients with COPD or asthma and the healthy volunteers (P <0.05),and there was significant difference between the patients with COPD and the patients with asthma(P <0.01). There was no significant difference in age,height,weight,and other general information among the three groups.There was no linear correlation between FeNO value and age,height,weight,body mass index,forced expiratory volume in the first second (FEVI)and FEVI to forced vital capacity(FEVI/FVC).Conclusions:The measured value of FeNO in patients with COPD and asthma are higher than that of healthy volunteers.There is no linear correlation between the measured value of FeNO and other values such as FEVI and FEVI/FVC,etc.The reason may be small sample size in this study.

Objective To explore the injury types and characteristics of children hospitalization with accidental injuries in a tertiary general hospital in Guangdong Province,and to provide important data evidences for reducing accidental injuries in children.Methods Children hospitalization of accidence in 2019-2021 from a tertiary general hospital were analyzed.The X2 test analysis was used for comparing different years,sources of patients and age difference between accident types.Results 1 561 children were hospitalized due to accidental injuries.The top three reasons were falling,traffic accidents and external inju-ries.There are significant differences among age groups and types of accident harm(x2=186.606,P＜0.001),and significant differences among different damage rate of surgery(x2=45.017,P＜0.001).The children who underwent surgery after injury were most likely to fall(72.3％).The accidental injuries occurred at home accounted for 88.8％,and therein the upper limb injuries were the main injuries(67.8％).Conclusion Accidental injuries in children's hospitalization are mainly caused by falls,traffic accidents,and external injuries.Targeted prevention should be carried out according to the types of injuries in differ-ent age groups,especially falls,which are the most harmful types of injuries in terms of incidence rate and surgical rate.There-fore,prevention and control should be emphasized.

OBJECTIVETo carry out genetic analysis for a fetus with Dandy-Walker malformation and provide prenatal diagnosis for its parents during the subsequent pregnancy.

METHODSRoutine G-banding was carried out to analyze the karyotype of the fetus and its parents, and next-generation sequencing (NGS) and fluorescence in situ hybridization (FISH) were used to verify the result.

RESULTSThe father showed a normal karyotype, while the mother was found to carry a balanced t(11; 22) (q23; q11) translocation. NGS and FISH analysis verified that the supernumerary marker chromosome carried by the fetus was der(22) t(11; 22) (q23;q11). The fetus was diagnosed with Emanuel syndrome. During the next pregnancy, the fetus was found to carry the same balanced translocation as its mother. After genetic counseling, the couple decided to continue with the pregnancy, and eventually delivered a healthy baby.

CONCLUSIONA fetal case of Emanuel syndrome has been identified. The derivative der(22) t(11; 22)(q23; q11) chromosome probably underlies the Dandy-Walker malformation in the fetus. Combined cytogenetic and molecular analyses can attain a more precise diagnosis for fetal abnormalities detected by ultrasonography.

Adult ; Chromosome Disorders ; diagnosis ; genetics ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 22 ; Cleft Palate ; diagnosis ; genetics ; Female ; Follow-Up Studies ; Heart Defects, Congenital ; diagnosis ; genetics ; Humans ; Intellectual Disability ; diagnosis ; genetics ; Muscle Hypotonia ; diagnosis ; genetics ; Pregnancy ; Prenatal Diagnosis ; Translocation, Genetic