Dabigatran etexilate mesylate(DE)and tadalafil(TD)are BCS class II drugs with poor water solubility. 〓 In this study coamorphization technique was used to improve their solubilities/dissolutions and hence to enhance their oral absorptions. The coamorphous DE-TD were prepared by solvent-evaporation method and characterized by PXRD, DSC, FTIR and TGA. In addition, dissolution behavior and physical stability were also investigated. Only halo pattern and a single Tg of 119 °C was observed on the PXRD and DSC of the co-evaporated product, respectively, indicating the formation of coamorphous DE-TD. FTIR result suggested that a hydrogen bond was probably formed between N-H group of DE and C==O group of TD. In comparison to crystalline counterparts, coamorphous DE-TD showed a significantly improved intrinsic dissolution rate and prolonged supersaturation time in intrinsic dissolution and supersaturation dissolution studies, respectively. No crystallization was observed under affecting factors testing(30 days)as well as long-term and accelerated stability testing(90 days)for the prepared coamorphous DE-TD under 25°C/60%RH or 40°C/75%RH, while amorphous DE crystalized at 10 days under 25 ℃/75% RH.

Objective:To explore the effect of phased nursing based on the compliance curve in pelvic floor function rehabilitation training for patients with stress urinary incontinence.Methods:From January 2019 to June 2020, convenience sampling was used to select 70 patients with stress urinary incontinence in the Urology Surgery, the Second Affiliated Hospital of Zhejiang Chinese Medical University as the research object. Patients were randomly divided into the control group and the intervention group with the random number table method, each with 35 cases. The control group conducted conventional nursing, and the intervention group carried out phased nursing based on the compliance curve on this basis. The treatment effects of the two groups after intervention were compared, and the self-efficacy and quality of life of the two groups of patients before and after the intervention were compared through the Pelvic Floor Muscle Training Self-Efficacy Scale and the Incontinence Quality of Life Questionnaire (I-QOL) .Results:After the intervention, the treatment effect of the intervention group was better than that of the control group, and the difference was statistically significant ( P<0.05) . After the intervention, the self-efficacy score of patients in the intervention group was (1 328.8±276.8) , which was higher than that (1 150.5±324.8) of the control group, and the difference was statistically significant ( P<0.05) . After the intervention, the total score and the scores of each dimension of the I-QOL of the intervention group were higher than those of the control group, and the differences were statistically significant (all P<0.05) . Conclusions:The phased nursing based on the compliance curve applied to the pelvic floor function rehabilitation training for patients with stress urinary incontinence can improve the treatment effect, self-efficacy and quality of life of the patients.