Objective:To evaluate mental health status of medical students and to explore its related factors.Methods:877 medical students were tested by Symptom Checklist(SCL-90),Simplified Coping Style Questionnaire(CPS),and the stressful events items;240 of them were tested by Eysenck Personality Questionnaire (EPQ).Results:①Compared with the SCL-90 norm of youth group,medical students had higher scores ( P

Objective To investigate non-psychiatric doctors' knowledge and attitude toward depression. Method Self-made Depressive Knowledge Questionaire (DKQ), which includes 24 items covering general knowledge, symptoms and other related questions of depression, were used in 346 non-psychiatric doctors who came from different grade general hospitals of Hunan. Results Average score of DKQ was 13.53±2.08,and corrective answering rates to different questions were 14.5％～95.4%.There were some associations between DKQ's score and grade of hospitals, subjects' education and attitude to depression. Conclusion It is necessary to re-educate non-psychiatric doctors with depressive knowledge.

Objective: To investigate the relationship between academic achievements of high school students and the results of California Psychological Inventory (CPI) of them. Method: Seventy-one higher school students were tested by CPI-RC (revised Chinese version). Their academic achievements were recorded. Results: Nine of the 23 CPI traits, such as Re (responsibility), So (socialize), Wb (comfortable), Ac (achievement), Py (psychologized), Cm (communality), To (tolerance), Sc (self-control), V3 (self accomplishment) had significant correlation with academic achievements (r=0.24～0.33, p＜0.05). Students with different prefer (literal arts or science) showed different CPI traits. Students with better academic achievements had higher scores on So, Sc, Wb, To and V3. Conclusion: CPI traits have some relationship to academic achievements of high school students and to their academic preference.

Objective: To explore the relation of psychological abuse and neglect in childhood and college students’ mental health. Methods: Cluster sampling was used to select 457 college students studying in the Central South University and Hunan Commercial College as subjects. The general information questionnaire,Child Psychological Abuse and Neglect Scale (CPANS) and Symptom Checklist 90 (SCL-90) were completed by all subjects. Results: 45.30% of the respondents experienced psychological abuse or neglect in childhood. The total score and scores of each factor of SCL-90 of the group of psychological abuse combined with neglect was above those of psychological-abuse group,neglect-group and neither-abuse-nor-neglect-group. Additionally,ten factor scores and total score of SCL-90 of neglect-group were distinctly higher than those of neither-abuse-nor-neglect-group. The scores of each aspect and sub-scale of CPANS were significantly correlated with every factor and total score of SCL-90(P

Objective To explore the characteristics and influential factors of resilience in empty-nest elderly with mild cognitive impairment(MCI) living in the poor area.Methods A total of 1 188 empty-nest elderly in the poor area of Hunan was sampled,analysis of covariance (ANCOVA),path analysis was used to analyze the data which were investigated by the two questionnaires including Index of SRQS.Results The prevalence of MCI in these 1 188 empty-nest elderly in rural area was 37.6％.The empty nest elderly in MCI group reported low resilience scores than those in cognitive normal group((58.84t 11.53) vs (63.58± 11.62) ; P＜0.001).ANCOVA and path analysis indicated that direct influences of income (β=3.324),education level (β=2.041),MoCA score (β=0.281) while age had indirect influences on it(β=-0.173).Conclusion Resilience in empty-nest elderly with MCI is low.Cognitive function,income and education are the direct influencing factor for resilience of the empty-nest elderly in the rural area.

OBJECTIVETo investigate in situ visualization using near-infrared quantum dots (QDs) conjugated with arginine- glycine-aspartic acid (ROD) peptide fluorescent probes in oral squamous cell carcinoma (08CC).

METHODSQDs with emission wavelength of 800 nm (QD800) were conjugated with RGD peptides to produce QD800-RGD fluorescent probes. Human OSCC cell line BcaCD885 was inoculated in nude mice cheeks to establish OSCC mouse models. Frozen BcaCD885 tumor slices were immunofluorescence double stained by using QD800-RGD and CD105 monoclonal antibody and were observed using a laser scanning confocal microscope. QD800-RGD was injected into the OSCC models through the tail veins, and the in situ visualization was analyzed at different time points. The mice were sacrificed 12 h after injection to isolate tumors for the ex vivo analysis of probe localization in the tumors.

RESULTSQD800-RGD specifically targeted the integrin avβ3 expressed in the endothelial cells of tumor angiogenic vessels in vitro and in vivo, producing clear tumor fluorescence images after intravenous injection. The most complete tumor images with maximal signal-to-noise ratios were observed 0.5 h to 6 h after injection of the probe and significantly reduced 9 h after the injection. However, the tumor image was still clearly visible at 12 h.

CONCLUSIONUsing intravenously injected QD800-RGD generates high quality OSCC images when integrin avβ3, which is expressed in the endothelial cells of tumor angiogenic vessels, is used as the target. The technique offers great potential in the diagnosis and individual treatment of OSCC.

Animals ; Arginine ; Aspartic Acid ; Carcinoma, Squamous Cell ; Cell Line, Tumor ; Fluorescent Dyes ; Glycine ; Humans ; Mice ; Mice, Nude ; Mouth Neoplasms ; Oligopeptides ; Peptides ; Quantum Dots

ObjectiveTo study the relationship between impulsive behavior and alexithymia in pupils in Changsha.Methods 702 pupils were tested with Barratt impulsivity scale (BIS-11) and Toronto alexithymia scale (TAS-20).Results ( 1 ) Male pupils had significantly higher scores of total BIS and non-planning impulsiveness than female (24.47 ± 5.30 vs 23.40 ± 5.59,P ＜ 0.05 ; 62.25 ± 9.46 vs 60.35 ± 9.91,P ＜ 0.05 ).Pupils in elder age group had only significantly higher total score of BIS than pupils in younger age group ( total:62.36 ± 9.69 vs 60.29 ± 9.68,P＜ 0.01 ).(2) Pupils with high impulsivity had significantly higher scores of total and factor scores of alexithymia than pupils with low impulsivity (total:57.43 ± 10.16 vs 46.55 ± 8.77,P ＜0.01 ).The total scores of BIS were positively correlated with total scores of alexithymia ( r =0.40,P ＜ 0.01 ) and factor scores of alexithymia ( r =0.25 ～ 0.33,P ＜ 0.01 ).Stepwise regression analysis revealed that total scores of BIS explained by DIF,DDF and EOT were 18％.ConclusionThere are certain gender and age differences in impulsivity impulsive behavior of 8 to 13 years old pupils.There exist the low to moderate correlations between impulsivity and alexithymia in pupils.

Objective To explore the correlation between the reliability and validity of Brunel balance assessment(BBA)with the activities of daily living(ADL).Methods The BBA,ADL and walking ability test were performed on 215 patients conforming to the inclusion standard by two professionals.The Pearson correlation analysis,factor analysis and descriptive statistical analysis were adopted.Results The BBA total score and Cronbach's α coefficient in 3 dimensions was 0.852～0.941(P＜0.01),moreover the relative coefficient of each item with its dimension was higher that that of other dimensions;3 common factors were extracted by the factor analysis,the contribution rate was 83.916％;but BBA had the ceiling effect,the relative coefficient of BBA with ADL and walking ability was 0.284-0.709(P＜0.05).Conclusion BBA has a good reliability and validity and can better reflect the functions of ADL and walk.

A novel method for the detection of moroxydine ( ABOB) residue in tomatoes was developed based on the enhancement of the fluorescence intensity of CdTe quantum dots( QDs) in the presence of ABOB. The factors influencing the performance of the QDs fluorescent probes were investigated, and the optimum conditions were determined:the concentration of mercaptoacidic acid ( TGA) capped-CdTe quantum dot was 1×10-4 mol/L, and the reaction time was 20 min at pH=5. 6. Under the optimum conditions, the relative fluorescence intensity increases linearly proportional to the ABOB concentration in the range of 1. 0×10-12-5. 0×10-10 mol/L with a limit of detection of 5. 2×10-13 mol/L, R=0. 9981, the recovery was 97%-106%, without obvious interference on the determinations of moroxydine from the common coexisting ions, antibiotics, and vitamins. The proposed method has been successfully applied in the detection of trace moroxydine hydrochloride residue in tomatoes.

Objective To study of zoledronic acid in the treatment of multiple myeloma bone dis-ease clinical effect and detection of serum macrophage inflammatory protein (MIP)changes of primary mye-loma (mm)in patients with serum macrophage inflammatory protein levels and multiple myeloma bone dis-ease curative effect.Methods 48 cases of multiple myeloma bone disease patients were treated with VTD regimen chemotherapy were randomly and equally divided into two groups,one group (group A)chemother-apy intermission applied zoledronic acid 4 mg per month 1 time,treatment 2 course of treatment,observa-tion of curative effect and adverse reaction,another group (B group)declined to azole phosphonic acid treatment.Results Group of pain Solution of 16 cases were markedly effective,effective in 4 cases,4 ca-ses were ineffective,efficiency 83.3%.B group bone pain relieved markedly effective in 12 cases,effective in 4 cases,8 cases were ineffective,have efficiency 66.7%.A compared to the B,the curative effect was obvious (P <0.05).By enzyme linked immunosorbent assay for the detection of the patients with a,levels of peripheral serum MIP-1a and MIP-1 beta B two groups before and after treatment.Conclusions zole-dronic acid in the treatment of multiple myeloma bone disease effectively,can significantly improve the qual-ity of life in patients with MM patients serum MIP-1a and MIP-1 beta level and multiple myeloma tumor bone disease curative effect is negative correlation,used for evaluating the effect The reference index.