1.Research progress on the immunosuppressive mechanism of co-inhibitory receptor T cell immunoglobulin and immunoglobulin and tyrosine-based inhibitory motif domain
Jun HUANG ; Jingjing JIANG ; Yunli BAO ; Na LI ; Ying ZHENG ; Xiaofeng ZHENG ; Xiaohui YU ; Jiucong ZHANG
Journal of Clinical Medicine in Practice 2024;28(5):135-138
The occurrence and development of malignant tumors are closely related to immune checkpoint receptors, and tumor cells can evade immune surveillance by activating the immune checkpoint pathway. T cell immunoglobulin and ITIM domain(TIGIT) is an inhibitory receptor expressed on lymphocytes, which can inhibit the function of natural killer cells(NK) and T cells through a variety of mechanisms, making tumor cells escape from the surveillance of the immune system. This article made a systematic review on the research progress of the immunosuppressive mechanism of TIGIT, and reviewed the research progress of the immunosuppressive mechanism of TIGIT.
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