BACKGROUND: Studies show that proper exercise has the effect of anti-aging, increasing bone mass accumulation and reducing bone mass loss. OBJECTIVE: To investigate the effect of aerobic exercises on osseous composition In aging rats. DESIGN, TIME AND SETTING: A randomized control animal experiment was completed in the Animal Experiment Laboratory of Xi'an Sports Institute from April to June in 2007. MATERIALS: A total of 64 clean male SD rats weaned for 2 months were randomly divided into a normal control group, a non-modeling exercise group, an aging model group and a modeling exercise group, with 16 ones in each group. Every 8 rats of each group were sacrificed at the 6th and 9th week respectively.exercise for 6 and 9 weeks. MAIN OUTCOME MEASURES: At the end of week 6 and 9, rats in each group were detected regarding to the following measures: serum alkaline phosphatase, bone gla protein, serum propeptide of type] procollagen, serum total calcium, serum inorganic phosphorus, serum magnesium, urinary calcium, urinary inorganic phosphorus, urinary magnesium, urinary hydroxylysine glycoside. Bone trabecula changes in femoral bone tissue were observed with light microscope. RESULTS: Compared with the normal control group, the aging model group got a decrease at the following indexes at both week 6 and week 9, namely, serum alkaline phosphatase, serum propeptide of type Ⅰ procellagen, serum total calcium, serum magnesium, urinary calcium, urinary inorganic phosphorus, urinary hydroxyproline. While in the non-modeling exercise group and the modeling exercise group, these above-mentioned indexes increased. Compared with the normal control group, the aging model group got an increase at the following indexes at both week 6 and week 9, namely, serum osteocalcin, inorganic phosphorus, adnary magnesium, urinary hydroxylysine glycoside. While in the non-modeling exercise group and the modeling exercise group, these above-mentioned indexes decreased. In Addition, exercise of 9 weeks led to a better recovery result than that of 6 weeks. The detection under light microscope showed an obvious few bone trabeculas in the aging model group and an increase of bone trabeculas per unit volume in the non-modeling exercise group and the modeling exercise group. CONCLUSION: Aerobic exercise has a great effect on the morphosis of femoral bone osseous composition in aging rats, and it can delay osteoporosis.

Objective To investigate the association between hypertriglyceridemia and acute pancreatitis in patients with type 2 diabetes,in order to guide the prevention and treatment of acute pancreatitis in patients with diabetes. Methods A total of 46 patients with type 2 dia-betes complicated by acute pancreatitis who were admitted to The First Hospital of Yulin from January 2013 to December 2016 were enrolled as study group,and 52 patients with type 2 diabetes alone who were admitted to our hospital within the same period of time were enrolled as control group. Related data were recorded,including age,sex,course of diabetes,body height and weight,abdominal circumference, smoking,drinking,gallstones,hypertension,blood glucose,and blood lipids [total cholesterol (TC),triglyceride (TG),high - density lipoprotein cholesterol (HDL - C),and low - density lipoprotein cholesterol (LDL - C)]. The incidence rates of complications associated with diabetes were analyzed. The chi - square test was used for comparison of categorical data (general status,blood lipids,and diabetic complications)between two groups;and the t - test was used for comparison of such data between two groups. A logistic regression analysis was used for multivariate analysis. Results There were no significant differences between the two groups in age,sex composition,body height and weight,abdominal circumference,smoking and drinking habits,hypertension,gallstones,and course of diabetes (all P >0. 05). The study group had significantly higher levels of TC,TG,and LDL - C than the control group (t = 5. 122,4. 127,and 3. 524, P < 0. 01,< 0. 01,and = 0. 012),while the control group had a significantly higher level of HDL - C than the study group (t = 2. 231, P = 0. 037). The study group had a significantly higher incidence rate of diabetic microangiopathy (diabetic retinopathy and chronic diabetic nephropathy)than the control group (χ2 = 92. 126,P < 0. 01). The multivariate analysis showed that compared with those with a normal TG level,the type 2 diabetic patients with a high TG level had a risk of acute pancreatitis increased by 47. 6% (odds ratio [OR]= 1. 476,P =0. 031),and the type 2 diabetic patients with a high LDL - C level had a risk of acute pancreatitis increased by 48. 7% (OR = 1. 487,P =0. 045). Conclusion Blood lipids should be measured for patients with type 2 diabetes,and blood glucose and blood lipid levels should be actively controlled for patients with type 2 diabetes complicated by hypertriglyceridemia,in order to reduce the incidence rate of acute pan-creatitis.

ObjectiveTo explore sleep disturbance in preschool children with autism spectrum disorder (ASD) and analyze the relationship between sleep disturbance and social behavior. MethodsFrom December, 2020 to December, 2022, 221 preschool children with ASD from Beijing Bo'ai Hospital and other two institutes, and 246 healthy preschool children socially recruited were investigated with Children's Sleep Habits Questionnaire (CSHQ). A total of 47 ASD children and 47 healthy children were selected from them to wear a sleep monitoring watch for seven days, while the ASD children were evaluated with Gesell Development Diagnosis Scale (GDDS), Psychoeducational Profile-Third Edition (PEP-3), Autism Diagnostic Observation Schedule-2 (ADOS), Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS) and Social Responsiveness Scale (SRS). ResultsAll the factor-scores were more in the ASD children than in the healthy children (t > 2.491, P < 0.05), except that of daytime sleepiness. The prevalence of sleep disturbance (CSHQ ≥ 41) was 89.6% in ASD children, which was more than that of the healthy children (76.8%) (χ² = 13.360, P < 0.001). The sleep problems in ASD children included bedtime resistance, sleep anxiety, sleep duration, sleep onset delay, parasomnias and sleep disordered breathing. ASD children were shorter in total bedtime, shorter in total sleep time, longer in sleep latency, longer in awake time and lower in sleep efficiency (|t| > 2.001, P < 0.05), compared with those of healthy children. For ASD children, the total bedtime negatively correlated with GDDS-language, PEP-3-expressive language, PEP-3-communication and PEP-3-maladaptive behaviors (r < -0.300, P < 0.05); the sleep efficiency negatively correlated with total score of CARS (r = -0.365, P < 0.05); sleep latency correlated with GDDS-social, PEP-3-cognitive, PEP-3-expressive language, PEP-3-receptive language, PEP-3-visual-motor imitation, PEP-3-characteristic verbal behaviors, PEP-3-communication, original score of ADOS, ADOS-social affect, and total score of CARS (|r| > 2.90, P < 0.05); and total awake time positively correlated with total score of CARS (r = 0.406, P < 0.05). ConclusionSleep disturbance is prevalent and various in preschool ASD children, and influence their social behaviors.