Objective To examine the effect of target muscle injection with different dosages of Methycobal in the sciatic nerve regeneration of adult rats so as to determine a better method and proper dosage of Methycobal for clinical treatment of peripheral nerve injury. Methods A total of 30 healthy Wistar rats were employed to make sciatic nerve injury model through immediate suture of the adventitia posterior to transection of the left sciatic nerve. The rats were divided randomly into three groups, ie, high dosage group (Methycobal for 300 ?g/kg, Group A), low dosage group (Methycobal for 100 ?g/kg, Group B) and control group (1 ml normal saline once a day, Group C),10 rats in each group. At 4 and 8 weeks, 5 rats from each group were taken to observe the effect of different dosages of Methycobal on rat sciatic nerve regeneration, where the detection indices included morphological changes and image analysis of sciatic nerves by optic and electron microscopic investigations as well as tricipital muscle wet weight. Results Four weeks after operation, tricipital muscle wet weight was (1.367?0.012) g in the Group A, (1.164? 0.011) gin the Group B and (0.950?0.009) g in the Group C, with significant difference among groups A, B and C (P

The accurate diagnosis and precise prediction of tumor radiation sensitivity and normal tissue radiation-induced injury are the preconditions of precise radiotherapy for lung cancer.Radiomics is defined as a set of milestone,assistive tools in the develop-ment of precise treatment for lung cancer,which can extract many quantitative features from medical images by applying automatic or semi-automatic methods and determine the deep relationship between clinical diagnosis and treatment data.Thus,the occurrence, development,and clinical outcome of lung cancer may be revealed.Radiomics holds immense potential in the classification of benign and malignant lung nodules,prediction of lung cancer genetic phenotypes,and treatment response to radiation therapy,because it can obtain information regarding the global heterogeneity of tumors via a noninvasive approach.In the present review,we summarize the latest process of CT-based radiomics in precise radiotherapy for lung cancer.