Chemistry, Clinical ; Diagnostic Tests, Routine ; Hemoglobin A, Glycosylated ; Humans

High-intensity interval training (HIIT), characterized by alternating intense exercise with short recovery periods, has emerged as an effective and time-efficient approach for diabetes management. HIIT is particularly recommended for individuals who are physically capable and have limited time, as per guidelines from the Korean Diabetes Association (KDA) and the American Diabetes Association (ADA). Studies indicate that HIIT can enhance aerobic capacity, reduce insulin resistance, and improve glycemic control while potentially decreasing cardiovascular risks, such as high blood pressure and lipid imbalances. Moreover, HIIT may help mitigate diabetes-related complications by improving vascular function and insulin sensitivity. However, HIIT carries certain risks, such as episodes of hyperglycemia, hypoglycemia, and an increased risk of musculoskeletal injury, particularly in older adults or those with lower fitness levels. Therefore, it is crucial that HIIT regimens be individualized and guided by healthcare professionals to ensure safe and effective integration into diabetes management.

High-intensity interval training (HIIT), characterized by alternating intense exercise with short recovery periods, has emerged as an effective and time-efficient approach for diabetes management. HIIT is particularly recommended for individuals who are physically capable and have limited time, as per guidelines from the Korean Diabetes Association (KDA) and the American Diabetes Association (ADA). Studies indicate that HIIT can enhance aerobic capacity, reduce insulin resistance, and improve glycemic control while potentially decreasing cardiovascular risks, such as high blood pressure and lipid imbalances. Moreover, HIIT may help mitigate diabetes-related complications by improving vascular function and insulin sensitivity. However, HIIT carries certain risks, such as episodes of hyperglycemia, hypoglycemia, and an increased risk of musculoskeletal injury, particularly in older adults or those with lower fitness levels. Therefore, it is crucial that HIIT regimens be individualized and guided by healthcare professionals to ensure safe and effective integration into diabetes management.

High-intensity interval training (HIIT), characterized by alternating intense exercise with short recovery periods, has emerged as an effective and time-efficient approach for diabetes management. HIIT is particularly recommended for individuals who are physically capable and have limited time, as per guidelines from the Korean Diabetes Association (KDA) and the American Diabetes Association (ADA). Studies indicate that HIIT can enhance aerobic capacity, reduce insulin resistance, and improve glycemic control while potentially decreasing cardiovascular risks, such as high blood pressure and lipid imbalances. Moreover, HIIT may help mitigate diabetes-related complications by improving vascular function and insulin sensitivity. However, HIIT carries certain risks, such as episodes of hyperglycemia, hypoglycemia, and an increased risk of musculoskeletal injury, particularly in older adults or those with lower fitness levels. Therefore, it is crucial that HIIT regimens be individualized and guided by healthcare professionals to ensure safe and effective integration into diabetes management.

High-intensity interval training (HIIT), characterized by alternating intense exercise with short recovery periods, has emerged as an effective and time-efficient approach for diabetes management. HIIT is particularly recommended for individuals who are physically capable and have limited time, as per guidelines from the Korean Diabetes Association (KDA) and the American Diabetes Association (ADA). Studies indicate that HIIT can enhance aerobic capacity, reduce insulin resistance, and improve glycemic control while potentially decreasing cardiovascular risks, such as high blood pressure and lipid imbalances. Moreover, HIIT may help mitigate diabetes-related complications by improving vascular function and insulin sensitivity. However, HIIT carries certain risks, such as episodes of hyperglycemia, hypoglycemia, and an increased risk of musculoskeletal injury, particularly in older adults or those with lower fitness levels. Therefore, it is crucial that HIIT regimens be individualized and guided by healthcare professionals to ensure safe and effective integration into diabetes management.

High-intensity interval training (HIIT), characterized by alternating intense exercise with short recovery periods, has emerged as an effective and time-efficient approach for diabetes management. HIIT is particularly recommended for individuals who are physically capable and have limited time, as per guidelines from the Korean Diabetes Association (KDA) and the American Diabetes Association (ADA). Studies indicate that HIIT can enhance aerobic capacity, reduce insulin resistance, and improve glycemic control while potentially decreasing cardiovascular risks, such as high blood pressure and lipid imbalances. Moreover, HIIT may help mitigate diabetes-related complications by improving vascular function and insulin sensitivity. However, HIIT carries certain risks, such as episodes of hyperglycemia, hypoglycemia, and an increased risk of musculoskeletal injury, particularly in older adults or those with lower fitness levels. Therefore, it is crucial that HIIT regimens be individualized and guided by healthcare professionals to ensure safe and effective integration into diabetes management.

PURPOSE: This study was done to assess the bone mineral density (BMD), biochemical bone turnover markers (BTMs), and factors associated with bone health in young Korean women. METHODS: Participants were 1,298 women, ages 18-29, recruited in Korea. Measurements were BMD by calcaneus quantitative ultrasound, BTMs for Calcium, Phosphorus, Osteocalcin, and C-telopeptide cross-links (CTX), body composition by physical measurements, nutrients by food frequency questionnaire and psychosocial factors associated with bone health by self-report. RESULTS: The mean BMD (Z-score) was -0.94. 8.7% women had lower BMD (Z-score< or =-2) and 14.3% women had higher BMD (Z-score< or = 0) than women of same age. BTMs were not significantly different between high-BMD (Z-score> or =0) and low-BMD (Z-score<0) women. However, Osteocalcin and CTX were higher in women preferring caffeine intake, sedentary lifestyle and alcoholic drinks. Body composition and Calcium intake were significantly higher in high-BMD. Low-BMD women reported significantly higher susceptibility and barriers to exercise in health beliefs, lower bone health self-efficacy and promoting behaviors. CONCLUSION: Results of this study indicate that bone health of young Korean women is not good. Development of diverse strategies to intervene in factors such as exercise, nutrients, self-efficacy, health beliefs and behaviors, shown to be important, are needed to improve bone health.
Adolescent ; Alcohol Drinking ; Asian Continental Ancestry Group ; Biological Markers/*metabolism ; Body Composition ; Bone Density ; Bone and Bones/*metabolism/radiography/ultrasonography ; Calcium/metabolism ; Collagen Type I/metabolism ; Female ; Health Promotion ; Humans ; Knowledge ; Life Style ; Osteocalcin/metabolism ; Peptides/metabolism ; Phosphorus/metabolism ; Republic of Korea ; Self Efficacy ; Women/*psychology ; Young Adult

The CD56 antigen is a cell adhesion molecule and its expression on tumor cells is thought to play a role in CD56-positive lymphomas and leukemias with unusual sites of involvement. As to chronic myelogenous leukemia (CML) and related blastic crisis, CD56 expression is not generally considered as a part of the CML phenotype and has rarely been reported in CML and other chronic myeloproliferative dirsorders (CMPD). We reported a case of CML expressing the CD56 antigen on the CD34-negative myeloid cells presented with extramedullary granulocytic sarcoma and examined the CD56 reactivity on bone marrow biopsy sections in 9 patients with CMPD. To assess the abnormal expression of the CD56 antigen on myeloid and progenitor cells from CMPD, immunohistochemical staining and flow cytometric analysis were performed on bone marrow biopsy sections and aspirate specimens, respectively. Of nine patients with CMPD, a case of CML in blastic crisis with extramedullary granulocytic sarcoma showed an abnormal expression of CD56 on CD34-negative myeloid cells. The expression of CD56 on CML myeloid elements seems to represent an aberrant phenomenon that could affect the pattern of tumor cell dissemination.
Antigens, CD56 ; Biopsy ; Bone Marrow ; Cell Adhesion ; Humans ; Leukemia ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive* ; Lymphoma ; Myeloid Cells* ; Phenotype ; Sarcoma, Myeloid ; Stem Cells

There have been few reports on chromosomal abnormalities in secondary hemophagocytic lym-phohistiocytosis (HLH) including Epstein-Barr virus-associated HLH (EBV-HLH). Clonality of HLH can be determined by karyotypic analysis, T-cell receptor or IgH rearrangement studies, and EBV genome terminal repeat investigation. Chromosome analysis in EBV-HLH is the most important tool currently available for assessment of case-by-case prognosis. We report a case of fatal EBV-HLH with clonal karyotype abnormality. A 57-year-old man was admitted with persistent high fever and hepatosplenomegaly. Laboratory data revealed pancytopenia, hypofibrinogenemia, coagulation abnormalities, and marked abnormalities of liver function tests. EBV-DNA was detected in the bone marrow by PCR. The bone marrow studies showed mature, benign-looking histiocytic hyperplasia with prominent hemophagocytosis and clonal chromosomal abnormality. Although the patient was treated with immunochemotherapy and antibiotics, he died of disseminated intravascular coagu-lopathy and sepsis. Considering this fatal clinical course, it is important to take intensive therapeutic measures if karyotype abnormality is noted in the treatment of EBV-HLH cases.
Anti-Bacterial Agents ; Bone Marrow ; Chromosome Aberrations ; Fever ; Genome ; Herpesvirus 4, Human ; Humans ; Hyperplasia ; Karyotype* ; Liver Function Tests ; Lymphohistiocytosis, Hemophagocytic* ; Middle Aged ; Pancytopenia ; Polymerase Chain Reaction ; Prognosis ; Receptors, Antigen, T-Cell ; Sepsis ; Terminal Repeat Sequences

The Korean government previously established a national blood policy and national blood system based on basic and essential legislation. This achievement was the result of collaborative efforts between the Korean Centers for Disease Control and Prevention, the Korean Society of Blood Transfusion, the Korean Society for Laboratory Medicine, the Laboratory Medicine Foundation, and/or the Korean Association of External Quality Assessment Service. To ensure a safe and effective transfusion, a comprehensive quality assurance (QA) system to assess every process from donor selection to transfusion is mandatory. From a blood safety perspective, selection of appropriate donor blood screening tests for transfusion-transmissible infections (TTI) and the QA program is of great importance. In this article, we review legislation regarding the national blood policy and national blood system as well as the selection logic regarding diagnostic immunologic tests for TTI and quality assurance efforts for TTI of each blood center.
Blood Safety ; Blood Transfusion ; Centers for Disease Control and Prevention (U.S.) ; Donor Selection ; Humans ; Immunologic Tests* ; Logic ; Mass Screening* ; Quality Control ; Tissue Donors